Microbial Cell Individuality and the Underlying Sources of Heterogeneity

Stochastic Gene Expression in a Single Cell

Elowitz, M. B., Levine, A. J., Siggia, E. D., & Swain, P. S. (2002) · Science · doi:10.1126/science.1070919 · Cited by 5,441 · see citing works

Bacterial Persistence as a Phenotypic Switch

Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952 · see citing works

Hsp90 as a capacitor for morphological evolution

Rutherford, S. L., & Lindquist, S. (1998) · Nature · doi:10.1038/24550 · Cited by 2,270 · see citing works

Stochasticity in gene expression: from theories to phenotypes

Kærn, M., Elston, T. C., Blake, W. J., & Collins, J. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1615 · Cited by 2,270 · see citing works

Noise in Gene Expression: Origins, Consequences, and Control

Raser, J. M., & O’Shea, E. K. (2005) · Science · doi:10.1126/science.1105891 · Cited by 1,719 · see citing works

Noise in eukaryotic gene expression

Blake, W. J., Kærn, M., Cantor, C. R., & Collins, J. J. (2003) · Nature · doi:10.1038/nature01546 · Cited by 1,636 · see citing works

Regulation of noise in the expression of a single gene

Özbudak, E. M., Thattai, M., Kurtser, I., Grossman, A. D., & van Oudenaarden, A. (2002) · Nature Genetics · doi:10.1038/ng869 · Cited by 1,559 · see citing works

Optimizing the success of random searches

Viswanathan, G. M., Buldyrev, S. V., Havlin, S., da Luz, M. G. E., Raposo, E. P., & Stanley, E. (1999) · Nature · doi:10.1038/44831 · Cited by 1,525 · see citing works

Stochastic Kinetic Analysis of Developmental Pathway Bifurcation in Phage λ-Infected Escherichia coli Cells

Arkin, A. P., Ross, J., & McAdams, H. H. (1998) · Genetics · doi:10.1093/genetics/149.4.1633 · Cited by 1,492 · see citing works

Making sense of it all: bacterial chemotaxis

Wadhams, G. H., & Armitage, J. P. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1524 · Cited by 1,480 · see citing works

Real-Time Kinetics of Gene Activity in Individual Bacteria

Golding, I., Paulsson, J., Zawilski, S. M., & Cox, E. C. (2005) · Cell · doi:10.1016/j.cell.2005.09.031 · Cited by 1,468 · see citing works

Control of Stochasticity in Eukaryotic Gene Expression

Raser, J. M., & O'Shea, E. K. (2004) · Science · doi:10.1126/science.1098641 · Cited by 1,425 · see citing works

Phenotypic Diversity, Population Growth, and Information in Fluctuating Environments

Kussell, E. L., & Leibler, S. (2005) · Science · doi:10.1126/science.1114383 · Cited by 1,357 · see citing works

Stochastic protein expression in individual cells at the single molecule level

Cai, L., Friedman, N., & Xie, X. S. (2006) · Nature · doi:10.1038/nature04599 · Cited by 1,145 · see citing works

Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability

Ferrell, J. E. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00314-9 · Cited by 1,121 · see citing works

Gene Regulation at the Single-Cell Level

Rosenfeld, N., Young, J. W., Alon, U., Swain, P. S., & Elowitz, M. B. (2005) · Science · doi:10.1126/science.1106914 · Cited by 1,104 · see citing works

Persister cells and tolerance to antimicrobials

Keren, I., Kaldalu, N., Spoering, A. L., Wang, Y., & Lewis, K. (2003) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00856-5 · Cited by 1,099 · see citing works

Probing Gene Expression in Live Cells, One Protein Molecule at a Time

Yu, J., Xiao, J., Ren, X., Lao, K., & Xie, X. S. (2006) · Science · doi:10.1126/science.1119623 · Cited by 918 · see citing works

Biofilms and Planktonic Cells of Pseudomonas aeruginosa Have Similar Resistance to Killing by Antimicrobials

Spoering, A. L., & Lewis, K. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.23.6746-6751.2001 · Cited by 907 · see citing works

Logic of the Yeast Metabolic Cycle: Temporal Compartmentalization of Cellular Processes

Tu, B. P., Kudlicki, A. S., Rowicka, M., & McKnight, S. L. (2005) · Science · doi:10.1126/science.1120499 · Cited by 889 · see citing works

Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analyses

Davey, H. M., & Kell, D. B. (1996) · Microbiological Reviews · doi:10.1128/mr.60.4.641-696.1996 · Cited by 879 · see citing works

Specialized Persister Cells and the Mechanism of Multidrug Tolerance in Escherichia coli

Keren, I., Shah, D., Spoering, A. L., Kaldalu, N., & Lewis, K. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.24.8172-8180.2004 · Cited by 857 · see citing works

Phase and Antigenic Variation in Bacteria

van der Woude, M. W., & Bäumler, A. J. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.3.581-611.2004 · Cited by 766 · see citing works

Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity

Levina, N. N., Tötemeyer, S. S., Stokes, N. R., Louis, P., Jones, M. A., & Booth, I. R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1730 · Cited by 715 · see citing works

An excitable gene regulatory circuit induces transient cellular differentiation

Süel, G. M., García‐Ojalvo, J., Liberman, L. M., & Elowitz, M. B. (2006) · Nature · doi:10.1038/nature04588 · Cited by 714 · see citing works

Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi

Cowen, L. E., & Lindquist, S. (2005) · Science · doi:10.1126/science.1118370 · Cited by 698 · see citing works

Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion

Becskei, A., Séraphin, B., & Serrano, L. G. (2001) · The EMBO Journal · doi:10.1093/emboj/20.10.2528 · Cited by 687 · see citing works

A yeast prion provides a mechanism for genetic variation and phenotypic diversity

True, H. L., & Lindquist, S. L. (2000) · Nature · doi:10.1038/35035005 · Cited by 672 · see citing works

Asymmetric Inheritance of Oxidatively Damaged Proteins During Cytokinesis

Aguilaniu, H., Gustafsson, L., Rigoulet, M., & Nyström, T. (2003) · Science · doi:10.1126/science.1080418 · Cited by 642 · see citing works

hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis

Moyed, H. S., & Bertrand, K. P. (1983) · Journal of Bacteriology · doi:10.1128/jb.155.2.768-775.1983 · Cited by 632 · see citing works

Programmed Death in Bacteria

Lewis, K. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.3.503-514.2000 · Cited by 614 · see citing works

An Ultrasensitive Bacterial Motor Revealed by Monitoring Signaling Proteins in Single Cells

Cluzel, P., Surette, M. G., & Leibler, S. (2000) · Science · doi:10.1126/science.287.5458.1652 · Cited by 613 · see citing works

Flocculation, adhesion and biofilm formation in yeasts

Verstrepen, K. J., & Klis, F. M. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05072.x · Cited by 589 · see citing works

Bacterial Persistence

Kussell, E. L., Kishony, R., Balaban, N. Q., & Leibler, S. (2005) · Genetics · doi:10.1534/genetics.104.035352 · Cited by 583 · see citing works

Cannibalism by sporulating bacteria.

González-Pastor, J. E., Hobbs, E. C., & Losick, R. (2003) · Science · doi:10.1126/science.1086462 · Cited by 579 · see citing works

White-Opaque Switching in Candida albicans Is Controlled by Mating-Type Locus Homeodomain Proteins and Allows Efficient Mating

Miller, M. G., & Johnson, A. D. (2002) · Cell · doi:10.1016/s0092-8674(02)00837-1 · Cited by 569 · see citing works

"White-opaque transition": a second high-frequency switching system in Candida albicans

Slutsky, B., Staebell, M., Anderson, J., Risen, L., Pfaller, M. A., & Soll, D. R. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.1.189-197.1987 · Cited by 564 · see citing works

Stochastic Gene Expression in Fluctuating Environments

Thattai, M., & van Oudenaarden, A. (2004) · Genetics · doi:10.1534/genetics.167.1.523 · Cited by 526 · see citing works

Persister cells and the riddle of biofilm survival

Lewis, K. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0111-6 · Cited by 523 · see citing works

Non-genetic individuality: chance in the single cell

Spudich, J. L., & Koshland, D. E. (1976) · Nature · doi:10.1038/262467a0 · Cited by 522 · see citing works

Evolutionary capacitance as a general feature of complex gene networks

Bergman, A., & Siegal, M. L. (2003) · Nature · doi:10.1038/nature01765 · Cited by 520 · see citing works

Single-Cell Microbiology: Tools, Technologies, and Applications

Brehm‐Stecher, B. F., & Johnson, E. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.3.538-559.2004 · Cited by 503 · see citing works

Molecular switches — the ON and OFF of bacterial phase variation

Henderson, I. R., Owen, P., & Nataro, J. P. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01555.x · Cited by 501 · see citing works

Phenotypic variation in bacteria: the role of feedback regulation

Smits, W. K., Kuipers, O. P., & Veening, J. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1381 · Cited by 497 · see citing works

TANDEM GENETIC DUPLICATIONS IN PHAGE AND BACTERIA

Anderson, R. P., & Roth, J. R. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.002353 · Cited by 476 · see citing works

From molecular noise to behavioural variability in a single bacterium

Korobkova, E. A., Emonet, T., Vilar, J. M. G., Shimizu, T. S., & Cluzel, P. (2004) · Nature · doi:10.1038/nature02404 · Cited by 455 · see citing works

Prediction and measurement of an autoregulatory genetic module

Isaacs, F. J., Hasty, J., Cantor, C. R., & Collins, J. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332628100 · Cited by 436 · see citing works

Regulated cell-to-cell variation in a cell-fate decision system

Colman‐Lerner, A., Gordon, A. H., Serra, E., Chin, T., Resnekov, O., Endy, D., Pesce, C. G., & Brent, R. (2005) · Nature · doi:10.1038/nature03998 · Cited by 428 · see citing works

Noise Minimization in Eukaryotic Gene Expression

Fraser, H. B., Hirsh, A. E., Giaever, G. N., Kumm, J., & Eisen, M. B. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020137 · Cited by 419 · see citing works

Gene expression from plasmids containing the araBAD promoter at subsaturating inducer concentrations represents mixed populations

Siegele, D. A., & Hu, J. C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8168 · Cited by 418 · see citing works

High-Frequency Switching of Colony Morphology in Candida albicans

Slutsky, B., Buffo, J., & Soll, D. R. (1985) · Science · doi:10.1126/science.3901258 · Cited by 400 · see citing works

Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis

Korch, S. B., Henderson, T. A., & Hill, T. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03779.x · Cited by 400 · see citing works

Genetic and Epigenetic Regulation of the FLO Gene Family Generates Cell-Surface Variation in Yeast

Halme, A., Bumgarner, S. L., Styles, C. A., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00118-7 · Cited by 365 · see citing works

Cell population heterogeneity during growth of Bacillus subtilisPreprint

Kearns, D. B., & Losick, R. M. (2005) · Genes & Development · doi:10.1101/gad.1373905 · Cited by 359 · see citing works

Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits

True, H. L., Berlin, I., & Lindquist, S. L. (2004) · Nature · doi:10.1038/nature02885 · Cited by 331 · see citing works

A genomewide oscillation in transcription gates DNA replication and cell cycle

Klevecz, R. R., Bolen, J., Forrest, G., & Murray, D. B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306490101 · Cited by 321 · see citing works

Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0APreprint

Fujita, M., & Losick, R. M. (2005) · Genes & Development · doi:10.1101/gad.1335705 · Cited by 307 · see citing works

Bistability in the Bacillus subtilis K‐state (competence) system requires a positive feedback loop

Maamar, H., & Dubnau, D. A. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04592.x · Cited by 295 · see citing works

A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria

Voss, T. S., Healer, J., Marty, A. J., Duffy, M. F., Thompson, J. K., Beeson, J. G., Reeder, J. C., Crabb, B. S., & Cowman, A. F. (2005) · Nature · doi:10.1038/nature04407 · Cited by 291 · see citing works

Design principles of a bacterial signalling network

Kollmann, M., Løvdok, L., Bartholomé, K., Timmer, J., & Sourjik, V. (2005) · Nature · doi:10.1038/nature04228 · Cited by 285 · see citing works

Origins of extrinsic variability in eukaryotic gene expression

Volfson, D., Marciniak, J. Y., Blake, W. J., Ostroff, N. A., Tsimring, L. S., & Hasty, J. (2005) · Nature · doi:10.1038/nature04281 · Cited by 269 · see citing works

Filtering transcriptional noise during development: concepts and mechanisms

Arias, A. M., & Hayward, P. C. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1750 · Cited by 256 · see citing works

Evolution of a Combinatorial Transcriptional Circuit

Tsong, A. E., Miller, M. G., Raisner, R. M., & Johnson, A. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00885-7 · Cited by 250 · see citing works

In Candida albicans, White-Opaque Switchers Are Homozygous for Mating Type

Lockhart, S. R., Pujol, C., Daniels, K. J., Miller, M. G., Johnson, A. D., Pfaller, M. A., & Soll, D. R. (2002) · Genetics · doi:10.1093/genetics/162.2.737 · Cited by 235 · see citing works

Phenotypic Tolerance: Antibiotic Enrichment of Noninherited Resistance in Bacterial Populations

Wiuff, C., Zappala, R. M., Regoes, R. R., Garner, K. N., Baquero, F., & Levin, B. R. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.4.1483-1494.2005 · Cited by 215 · see citing works

Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion‐mediated mechanism

Eaglestone, S., Cox, B. S., & Tuite, M. F. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1974 · Cited by 215 · see citing works

Persister cells, the biofilm matrix and tolerance to metal cations in biofilm and planktonic Pseudomonas aeruginosa

Harrison, J. J., Turner, R. J., & Ceri, H. (2005) · Environmental Microbiology · doi:10.1111/j.1462-2920.2005.00777.x · Cited by 213 · see citing works

Stress and the Single Cell: Intrapopulation Diversity Is a Mechanism to Ensure Survival upon Exposure to Stress

Booth, I. R. (2002) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(02)00239-8 · Cited by 211 · see citing works

Stripping Bacillus : ComK auto‐stimulation is responsible for the bistable response in competence development

Smits, W. K., Eschevins, C., Susanna, K. A., Bron, S., Kuipers, O. P., & Hamoen, L. W. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04488.x · Cited by 195 · see citing works

Evolutionary conservation of prion‐forming abilities of the yeast Sup35 protein

Chernoff, Y. O., Galkin, A. P., Lewitin, E., Chernova, T. A., Newnam, G. P., & Belenkiy, S. M. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01761.x · Cited by 193 · see citing works

Phosphatases modulate the bistable sporulation gene expression pattern in Bacillus subtilis

Veening, J., Hamoen, L. W., & Kuipers, O. P. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04659.x · Cited by 185 · see citing works

Measurement of SOS expression in individual Escherichia coli K‐12 cells using fluorescence microscopy

McCool, J. D., Long, E., Petrosino, J. F., Sandler, H. A., Rosenberg, S. M., & Sandler, S. J. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04225.x · Cited by 169 · see citing works

Rapid, Transient Fluconazole Resistance in <i>Candida albicans</i> Is Associated with Increased mRNA Levels of <i>CDR</i>

Marr, K. A., Lyons, C. N., Rustad, T., Bowden, R. A., & White, T. C. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.10.2584 · Cited by 166 · see citing works

Playing Dr Jekyll and Mr Hyde: combined mechanisms of phase variation in bacteria

Hallet, B. (2001) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00253-8 · Cited by 163 · see citing works

Differential oxidative damage and expression of stress defence regulons in culturable and non‐culturable Escherichia coli cells

Desnues, B., Cuny, C., Grégori, G., et al. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor799 · Cited by 162 · see citing works

Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisiae

Jacquet, M., Renault, G., Lallet, S., Mey, J. D., & Goldbeter, A. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200303030 · Cited by 147 · see citing works

Revisited gene regulation in bacteriophage λ

Dodd, I. B., Shearwin, K. E., & Egan, J. B. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.02.001 · Cited by 140 · see citing works

Heteroresistance to Fluconazole and Voriconazole in <i>Cryptococcus neoformans</i>

Mondon, P., Petter, R., Amalfitano, G., Luzzati, R., Concia, E., Polacheck, I., & Kwon-Chung, K. J. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.8.1856 · Cited by 139 · see citing works

Phenotypic switching in Candida albicans is controlled by a SIR2 gene

Pérez‐Martín, J., Urı́a, J. A., & Johnson, A. D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.9.2580 · Cited by 137 · see citing works

The Mechanism by which DNA Adenine Methylase and PapI Activate the Pap Epigenetic Switch

Hernday, A. D., Braaten, B. A., & Low, D. A. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00383-6 · Cited by 135 · see citing works

The Histone Deacetylase GenesHDA1andRPD3Play Distinct Roles in Regulation of High-Frequency Phenotypic Switching inCandida albicans

Srikantha, T., Tsai, L., Daniels, K. G., Klar, A. J. S., & Soll, D. R. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.15.4614-4625.2001 · Cited by 132 · see citing works

Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxygen species, and ageing in

Drakulic, T., Temple, M. D., GUIDO, R., Jarolim, S., Breitenbach, M., Attfield, P. V., & Dawes, I. W. (2005) · FEMS Yeast Research · doi:10.1016/j.femsyr.2005.06.001 · Cited by 130 · see citing works

Coherence and Timing of Cell Cycle Start Examined at Single-Cell Resolution

Bean, J. M., Siggia, E. D., & Cross, F. R. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.10.035 · Cited by 126 · see citing works

Oxidative protein damage causes chromium toxicity in yeast

Sumner, E. R., Shanmuganathan, A., Sideri, T. C., et al. (2005) · Microbiology · doi:10.1099/mic.0.27945-0 · Cited by 118 · see citing works

Effect of cell cycle position on thermotolerance in Saccharomyces cerevisiae

Plesset, J., Ludwig, J. R., Cox, B. S., & McLaughlin, C. S. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.2.779-784.1987 · Cited by 111 · see citing works

Hydrogen Peroxide Causes RAD9-dependent Cell Cycle Arrest in G2 in Saccharomyces cerevisiae whereas Menadione Causes G1 Arrest Independent of RAD9 Function

Flattery-O'Brien, J. A., & Dawes, I. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8564 · Cited by 111 · see citing works

Phenotypic heterogeneity: differential stress resistance among individual cells of the yeast Saccharomyces cerevisiae

Sumner, E. R., & Avery, S. V. (2002) · Microbiology · doi:10.1099/00221287-148-2-345 · Cited by 111 · see citing works

Mutants of Escherichia coli K-12 exhibiting reduced killing by both quinolone and beta-lactam antimicrobial agents

Wolfson, J. S., Hooper, D. C., McHugh, G., Bozza, M. A., & Swartz, M. N. (1990) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.34.10.1938 · Cited by 110 · see citing works

Regulation of antigen gene expression in

Pays, É. (2005) · Trends in Parasitology · doi:10.1016/j.pt.2005.08.016 · Cited by 105 · see citing works

hflB, a new Escherichia coli locus regulating lysogeny and the level of bacteriophage lambda cII protein

Banuett, F., Hoyt, M. A., McFarlane, L., et al. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90229-9 · Cited by 99 · see citing works

Origins of Individual Swimming Behavior in Bacteria

Levin, M. D., Morton-Firth, C. J., Abouhamad, W. N., et al. (1998) · Biophysical Journal · doi:10.1016/s0006-3495(98)77777-x · Cited by 95 · see citing works

Sorbic acid resistance: the inoculum effect

Steels, H., James, S. A., Roberts, I. N., & Stratford, M. (2000) · Yeast · doi:10.1002/1097-0061(20000930)16:13 · Cited by 92 · see citing works

A Histone Deacetylation Inhibitor and Mutant Promote Colony-Type Switching of the Human Pathogen Candida albicans

Klar, A. J. S., Srikantha, T., & Soll, D. R. (2001) · Genetics · doi:10.1093/genetics/158.2.919 · Cited by 92 · see citing works

Chromosome Loss Followed by Duplication Is the Major Mechanism of Spontaneous Mating-Type Locus Homozygosis in Candida albicans

Wu, W., Pujol, C., Lockhart, S. R., & Soll, D. R. (2005) · Genetics · doi:10.1534/genetics.104.033167 · Cited by 86 · see citing works

Regulation of the Pap Epigenetic Switch by CpxAR

Hernday, A. D., Braaten, B. A., Broitman-Maduro, G., Engelberts, P. J., & Low, D. A. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.020 · Cited by 82 · see citing works

Mating‐type locus homozygosis, phenotypic switching and mating: a unique sequence of dependencies in Candida albicans

Soll, D. R. (2003) · BioEssays · doi:10.1002/bies.10379 · Cited by 79 · see citing works

Silent repair accounts for cell cycle specificity in the signaling of oxidative DNA lesions

Leroy, C., Mann, C., & Marsolier‐Kergoat, M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2896 · Cited by 78 · see citing works

Antigenic variation in Babesia bovis occurs through segmental gene conversion of the ves multigene family, within a bidirectional locus of active transcription

Al‐Khedery, B., & Allred, D. R. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04993.x · Cited by 77 · see citing works

Phenotypic Switching and Mating Type Switching of <i>Candida glabrata</i> at Sites ofColonization

Brockert, P. J., Lachke, S. A., Srikantha, T., Pujol, C., Galask, R., & Soll, D. R. (2003) · Infection and Immunity · doi:10.1128/iai.71.12.7109-7118.2003 · Cited by 75 · see citing works

Involvement of glutathione in the regulation of respiratory oscillation during a continuous culture of Saccharomyces cerevisiae

Murray, D. B., Lloyd, D., Kuriyama, H., & Engelen, F. (1999) · Microbiology · doi:10.1099/00221287-145-10-2739 · Cited by 74 · see citing works

Diversify or Die: Generation of Diversity in Response to Stress

Aertsen, A., & Michiels, C. W. (2005) · Critical Reviews in Microbiology · doi:10.1080/10408410590921718 · Cited by 73 · see citing works

Clonal variation in maximum specific growth rate and susceptibility towards antimicrobials

Sufya, N., Allison, D., & Gilbert, P. (2003) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2003.02079.x · Cited by 73 · see citing works

Non‐genetic population heterogeneity studied by in situ polymerase chain reaction

Tolker‐Nielsen, T., Holmstrøm, K., Boe, L., & Molin, S. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00760.x · Cited by 69 · see citing works

The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes

Horn, D., & Barry, J. D. (2005) · Chromosome Research · doi:10.1007/s10577-005-0991-8 · Cited by 68 · see citing works

The epigenetic control of antigenic variation in Plasmodium falciparum

Ralph, S. A., & Scherf, A. (2005) · Current Opinion in Microbiology · doi:10.1016/j.mib.2005.06.007 · Cited by 67 · see citing works

The Intricate Workings of a Bacterial Epigenetic Switch

Hernday, A. D., Braaten, B. A., & Low, D. A. (2004) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8861-4_7 · Cited by 60 · see citing works

Binding of the Chemotaxis Response Regulator CheY to the Isolated, Intact Switch Complex of the Bacterial Flagellar Motor

Sagi, Y., Khan, S., & Eisenbach, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303201200 · Cited by 60 · see citing works

Heterogeneity of stress gene expression and stress resistance among individual cells of Saccharomyces cerevisiae

Attfield, P. V., Choi, H. Y., Veal, D. A., & Bell, P. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02444.x · Cited by 57 · see citing works

The essential role of the cro gene in lytic development by bacteriophage λ

Folkmanis, A., Maltzman, W., Mellon, P. L., et al. (1977) · Virology · doi:10.1016/0042-6822(77)90151-9 · Cited by 55 · see citing works

Single-cell Analysis of λ Immunity Regulation

Bæk, K. T., Svenningsen, S. L., Eisen, H., et al. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.09.037 · Cited by 55 · see citing works

Hetero-resistance: an under-recognised confounder in diagnosis and therapy?

Editors, T. (2001) · Journal of Medical Microbiology · doi:10.1099/0022-1317-50-12-1018 · Cited by 55 · see citing works

Quantification and Characterization of Phagocytosis in the Soil Amoeba Acanthamoeba castellanii by Flow Cytometry

Avery, S. V., Harwood, J. L., & Lloyd, D. (1995) · Applied and Environmental Microbiology · doi:10.1128/aem.61.3.1124-1132.1995 · Cited by 52 · see citing works

Cell cycle‐ and age‐dependent activation of Sod1p drives the formation of stress resistant cell subpopulations within clonal yeast cultures

Sumner, E. R., Avery, A. M., Houghton, J. E., Robins, R. A., & Avery, S. V. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03715.x · Cited by 44 · see citing works

Cellular stress responses oscillate in synchronization with the ultradian oscillation of energy metabolism in the yeastSaccharomyces cerevisiae

Wang, J., Liu, W., Uno, T., et al. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09198.x · Cited by 44 · see citing works

Flow cytometric investigation of heterogeneous copper-sensitivity in asynchronously grownSaccharomyces cerevisiae

Howlett, N. G., & Avery, S. V. (1999) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1999.tb13687.x · Cited by 44 · see citing works

Physiological States of Individual Salmonella typhimurium Cells Monitored by In Situ Reverse Transcription-PCR

Holmstrøm, K., Tolker‐Nielsen, T., & Molin, S. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.6.1733-1738.1999 · Cited by 42 · see citing works

Stochastic Processes Influence Stationary-Phase Decisions in Bacillus subtilis

Maughan, H., & Nicholson, W. L. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.7.2212-2214.2004 · Cited by 42 · see citing works

Co-regulation of Acetylation and Phosphorylation of CheY, A Response Regulator in Chemotaxis of Escherichia coli

Barak, R., & Eisenbach, M. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.07.021 · Cited by 40 · see citing works

Switch of phenotype as an escape mechanism of the intruder

Odds, F. C. (1997) · Mycoses · doi:10.1111/j.1439-0507.1997.tb00556.x · Cited by 39 · see citing works

Induction of Phenotypes Resembling CuZn-Superoxide Dismutase Deletion in Wild-Type Yeast Cells: An in Vivo Assay for the Role of Superoxide in the Toxicity of Redox-Cycling Compounds

Wallace, M. A., Bailey, S., Fukuto, J. M., Valentine, J. S., & Gralla, E. B. (2005) · Chemical Research in Toxicology · doi:10.1021/tx050050n · Cited by 35 · see citing works

Noise in gene expression as the source of non‐genetic individuality in the chemotactic response of Escherichia coli

Levin, M. D. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00857-3 · Cited by 33 · see citing works

Cell individuality: the bistability of competence development

Avery, S. V. (2005) · Trends in Microbiology · doi:10.1016/j.tim.2005.08.006 · Cited by 33 · see citing works

Fatal attraction

Shi, W., & Zusman, D. R. (1993) · Nature · doi:10.1038/366414a0 · Cited by 30 · see citing works

Analysis of the Upstream Regulatory Region of the GTS1 Gene Required for Its Oscillatory Expression

Tonozuka, H., Wang, J., Mitsui, K., et al. (2001) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a003023 · Cited by 29 · see citing works

Phenotypic Switching inCandida glabrataAccompanied by Changes in Expression of Genes with Deduced Functions in Copper Detoxification and Stress

Srikantha, T., Zhao, R., Daniels, K. J., Radke, J. B., & Soll, D. R. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.8.1434-1445.2005 · Cited by 27 · see citing works

Conformation induction in melanotropic peptides by trifluoroethanol: fluorescence and circular dichroism study

Mukhopadhyay, K., & Basak, S. (1998) · Biophysical Chemistry · doi:10.1016/s0301-4622(98)00177-x · Cited by 24 · see citing works

Copper/Zinc-Superoxide Dismutase Is Required for Oxytetracycline Resistance of Saccharomyces cerevisiae

Avery, S. V., Malkapuram, S., Mateus, C., & Babb, K. S. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.1.76-80.2000 · Cited by 23 · see citing works

mecA Is Not Involved in the σ B -Dependent Switch of the Expression Phenotype of Methicillin Resistance in Staphylococcus epidermidis

Knobloch, J. K. ‐., Jäger, S., Huck, J., et al. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.3.1216-1219.2005 · Cited by 21 · see citing works

Investigating phenotypes resulting from a lack of superoxide dismutase in bacterial null mutants

Touati, D. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)49330-5 · Cited by 13 · see citing works

Telomerase activity in human germline and embryonic tissues and cells

Wright, W. E., Piatyszek, M. A., Rainey, W. E., Byrd, W., & Shay, J. W. (1996) · Developmental Genetics · doi:10.1002/(sici)1520-6408(1996)18:2

Persister cells, dormancy and infectious disease

Lewis, K. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1557 · Cited by 2,052 · see citing works

Persister cells

Lewis, K. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134306 · Cited by 1,858 · see citing works

Bet Hedging in Yeast by Heterogeneous, Age-Correlated Expression of a Stress Protectant

Levy, S. F., Ziv, N., & Siegal, M. L. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001325 · Cited by 371 · see citing works

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.

Cowen, L. E. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1835 · Cited by 311 · see citing works

Advancing microbial sciences by individual-based modelling

Hellweger, F. L., Clegg, R. J., Clark, J. R., Plugge, C. M., & Kreft, J.-U. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.62 · Cited by 202 · see citing works

Culture History and Population Heterogeneity as Determinants of Bacterial Adaptation: the Adaptomics of a Single Environmental Transition

Ryall, B., Eydallin, G., & Ferenci, T. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05028-11 · Cited by 160 · see citing works

Cellular redox homeostasis, reactive oxygen species and replicative ageing in <i>Saccharomyces cerevisiae</i>

Ayer, A., Gourlay, C. W., & Dawes, I. W. (2014) · FEMS Yeast Research · doi:10.1111/1567-1364.12114 · Cited by 125 · see citing works

Defining Division of Labor in Microbial Communities

Giri, S., Waschina, S., Kaleta, C., & Kost, C. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.06.023 · Cited by 89 · see citing works

Pectin based banana peel extract as a stabilizing agent in zinc oxide nanoparticles synthesis

Dmochowska, A., Czajkowska, J., Jędrzejewski, R., Stawiński, W., Migdał, P., & Fiedot-Toboła, M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.042 · Cited by 65 · see citing works

Patchy distribution of flexible genetic elements in bacterial populations mediates robustness to environmental uncertainty: Population-level robustness through genome flexibility

Heuer, H., Abdo, Z., & Smalla, K. (2008) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2008.00539.x · Cited by 64 · see citing works

Microbiota of Cheese Ecosystems: A Perspective on Cheesemaking

Neviani, E., Gatti, M., Gardini, F., & Levante, A. (2025) · Foods · doi:10.3390/foods14050830 · Cited by 39 · see citing works

Colony and Single Cell Level Analysis of the Heterogeneous Response of Cryptococcus neoformans to Fluconazole

Altamirano, S., Simmons, C., & Kozubowski, L. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00203 · Cited by 19 · see citing works

Single-Cell Phenotypic Analysis and Digital Molecular Detection Linkable by a Hydrogel Bead-Based Platform

Zhu, Y., Li, J., Lin, X., Huang, X., & Hoffmann, M. R. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c01615 · Cited by 18 · see citing works

The Microbial Community of Natural Whey Starter: Why Is It a Driver for the Production of the Most Famous Italian Long-Ripened Cheeses?

Neviani, E., Levante, A., & Gatti, M. (2024) · Fermentation · doi:10.3390/fermentation10040186 · Cited by 17 · see citing works

The Natural Whey Starter Used in the Production of Grana Padano and Parmigiano Reggiano PDO Cheeses: A Complex Microbial Community

Neviani, E. (2024) · Microorganisms · doi:10.3390/microorganisms12122443 · Cited by 5 · see citing works

From the Single Bacterial Cell to the Microbial Community: A Round Trip to Better Understand the Secrets of Complex Microbiological Ecosystems

Erasmo, N. (2024) · International Journal of Clinical Microbiology and Biochemical Technology · doi:10.29328/journal.ijcmbt.1001029 · Cited by 1 · see citing works

Epigenetic Modifiers as Game Changers for Healthy Aging

Sharma, S., & Bhonde, R. R. (2023) · Rejuvenation Research · doi:10.1089/rej.2022.0059 · Cited by 10 · see citing works

Epigenetik bei entzündlichen Systemerkrankungen

Ospelt, C., & Gay, S. (2014) · Der Internist · doi:10.1007/s00108-013-3373-x · Cited by 4 · see citing works

Epigenetic Mechanisms and Therapeutic Perspectives for Neurodevelopmental Disorders

Kubota, T., Hirasawa, T., & Miyake, K. (2012) · Pharmaceuticals · doi:10.3390/ph5040369 · Cited by 27 · see citing works

Epigenetic Responses to Diet in Aging

Ford, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00016-9 · Cited by 3 · see citing works

The EDCs as epigenetic disruptors: Implications for development and health

Herráez, M. P., Lombó, M., & González-Rojo, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824464-7.00022-2 · Cited by 3 · see citing works