The DOI matches its Crossref record.
YaeT (Omp85) affects the assembly of lipid‐dependent and lipid‐independent outer membrane proteins of Escherichia coli
Open accessAbstract
Summary: The Omp85 family of proteins has been found in all Gram‐negative bacteria and even several eukaryotic organisms. The previously uncharacterized Escherichia coli member of this family is YaeT. The results of this study, consistent with previous Omp85 studies, show that the yaeT gene encodes for an essential cellular function. Direct examinations of the outer membrane fraction and protein assembly revealed that cells depleted for YaeT are severely defective in the biogenesis of outer membrane proteins (OMPs). Interestingly, assemblies of the two distinct groups of OMPs that follow either SurA‐ and lipopolysaccharide‐dependent (OmpF/C) or ‐independent (TolC) folding pathways were affected, suggesting that YaeT may act as a general OMP assembly factor. Depletion of cells for YaeT led to the accumulation of OMPs in the fraction enriched for periplasm, thus indicating that YaeT facilitates the insertion of soluble assembly intermediates from the periplasm to the outer membrane. Our data suggest that YaeT's role in the assembly of OMPs is not mediated through a role in lipid biogenesis, as debated for Omp85 in Neisseria, thus advocating a conserved OMP assembly function of Omp85 homologues.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Defining the roles of the periplasmic chaperones SurA, Skp, and DegP in Escherichia coli
Sklar, J. G., Wu, T., Kahne, D., & Silhavy, T. J. (2007) · Genes & Development · doi:10.1101/gad.1581007 · Cited by 459
Wu, T., McCandlish, A. C., Gronenberg, L. S., Chng, S.-S., Silhavy, T. J., & Kahne, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604744103 · Cited by 366
Robert, V., Volokhina, E. B., Senf, F., Bos, M. P., Gelder, P. V., & Tommassen, J. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040377 · Cited by 326
Malinverni, J. C., Werner, J., Kim, S., Sklar, J. G., Kahne, D., Misra, R., & Silhavy, T. J. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05211.x · Cited by 318
Self-citationA lipoprotein partner for the Escherichia coli outer membrane protein TolC
Horne, J., Kaplan, E., Jin, B., Abbott, K., Flores, V., Petsolari, E., Gradon, J., Ntsogo, Y., Harris, A., Yu, D., et al. (2026) · eLife · doi:10.7554/elife.110666.3 · Cited by 3
Metadata
- Authors
- Werner, J., & Misra, R.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2005-07-22
- Volume
- 57
- Issue
- 5
- Pages
- 1450-1459
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W1566092905
- Cited by
- 170
- References
- 0
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: YaeT (Omp85) affects the assembly of lipid‐dependent and lipid‐independent outer membrane proteins of Escherichia coli. https://app.cochat.ai/papers/10.1111/j.1365-2958.2005.04775.x
- The paper
- Werner, J., & Misra, R. (2005). YaeT (Omp85) affects the assembly of lipid‐dependent and lipid‐independent outer membrane proteins of Escherichia coli. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2005.04775.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
