The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cyclic‐diGMP signal transduction systems in Vibrio cholerae: modulation of rugosity and biofilm formation
Open accessAbstract
Summary: Cyclic di‐guanylic acid (c‐diGMP) is a second messenger that modulates the cell surface properties of several microorganisms. Concentrations of c‐diGMP in the cell are controlled by the opposing activities of diguanylate cyclases and phosphodiesterases, which are carried out by proteins harbouring GGDEF and EAL domains respectively. In this study, we report that the cellular levels of c‐diGMP are higher in the Vibrio cholerae rugose variant compared with the smooth variant. Modulation of cellular c‐diGMP levels by overexpressing proteins with GGDEF or EAL domains increased or decreased colony rugosity respectively. Several genes encoding proteins with either GGDEF or EAL domains are differentially expressed between the two V. cholerae variants. The generation and characterization of null mutants of these genes (cdgA–E, rocS and mbaA) revealed that rugose colony formation, exopolysaccharide production, motility and biofilm formation are controlled by their action. Furthermore, epistasis analysis suggested that cdgC, rocS and mbaA act in convergent pathways to regulate the phenotypic properties of the rugose and smooth variants, and are part of the VpsR, VpsT and HapR signal transduction pathway.
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Citations
Cites
Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
Drenkard, E., & Ausubel, F. M. (2002) · Nature · doi:10.1038/416740a · Cited by 997
Cited by
Roy, R., Tiwari, M., Donelli, G., & Tiwari, V. (2018) · Virulence · doi:10.1080/21505594.2017.1313372 · Cited by 1,523
Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms
Karatan, E., & Watnick, P. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00041-08 · Cited by 1,048
Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP
Sudarsan, N., Lee, E. R., Weinberg, Z., Moy, R. H., Kim, J. N., Link, K. H., & Breaker, R. R. (2008) · Science · doi:10.1126/science.1159519 · Cited by 719
Roles of Cyclic Diguanylate in the Regulation of Bacterial Pathogenesis
Tamayo, R., Pratt, J. T., & Camilli, A. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093426 · Cited by 486
Waters, C. M., Lu, W., Rabinowitz, J. D., & Bassler, B. L. (2008) · Journal of Bacteriology · doi:10.1128/jb.01756-07 · Cited by 425
Metadata
- Authors
- Lim, B., Beyhan, S., Meir, J., & Yildiz, F. H.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2006-03-03
- Volume
- 60
- Issue
- 2
- Pages
- 331-348
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2107943090
- Cited by
- 189
- References
- 1
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lim, B., Beyhan, S., Meir, J., & Yildiz, F. H. (2006). Cyclic‐diGMP signal transduction systems in Vibrio cholerae: modulation of rugosity and biofilm formation. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2006.05106.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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