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Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP
Open accessAbstract
Cyclic di-guanosine monophosphate (di-GMP) is a circular RNA dinucleotide that functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes, including cell differentiation, conversion between motile and biofilm lifestyles, and virulence gene expression. However, the mechanisms by which cyclic di-GMP regulates gene expression have remained a mystery. We found that cyclic di-GMP in many bacterial species is sensed by a riboswitch class in messenger RNA that controls the expression of genes involved in numerous fundamental cellular processes. A variety of cyclic di-GMP regulons are revealed, including some riboswitches associated with virulence gene expression, pilus formation, and flagellum biosynthesis. In addition, sequences matching the consensus for cyclic di-GMP riboswitches are present in the genome of a bacteriophage.
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Cited by
Gao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B. L., Zillinger, T., Serganov, A. A., Liu, Y., Jones, R. A., Hartmann, G., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.046 · Cited by 1,101
Serganov, A., & Nudler, E. (2013) · Cell · doi:10.1016/j.cell.2012.12.024 · Cited by 1,013
Widespread genetic switches and toxicity resistance proteins for fluoride
Baker, J. L., Sudarsan, N., Weinberg, Z., Roth, A., Stockbridge, R. B., & Breaker, R. R. (2012) · Science · doi:10.1126/science.1215063 · Cited by 438
Self-citationWeinberg, Z., Wang, J. X., Bogue, J., Yang, J., Corbino, K., Moy, R. H., & Breaker, R. R. (2010) · Genome Biology · doi:10.1186/gb-2010-11-3-r31 · Cited by 354
Self-citationMetabolite recognition principles and molecular mechanisms underlying riboswitch function
Serganov, A., & Patel, D. J. (2012) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-101211-113224 · Cited by 160
Metadata
- Authors
- Sudarsan, N., Lee, E. R., Weinberg, Z., Moy, R. H., Kim, J. N., Link, K. H., & Breaker, R. R.
- Venue
- Science
- Published
- 2008-07-18
- Volume
- 321
- Issue
- 5887
- Pages
- 411-413
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2048706341
- Cited by
- 719
- References
- 0
- FWCI
- 19.98
- Type
- journal article
- Language
- en
- Open access
- green
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