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Repression of Clostridium difficile toxin gene expression by CodY
Abstract
Summary: CodY, a global regulator of gene expression in low G + C Gram‐positive bacteria, was found to repress toxin gene expression in Clostridium difficile. Inactivation of the codY gene resulted in derepression of all five genes of the C. difficile pathogenicity locus during exponential growth and stationary phase. CodY was found to bind with high affinity to a DNA fragment containing the promoter region of the tcdR gene, which encodes a sigma factor that permits RNA polymerase to recognize promoters of the two major toxin genes as well as its own promoter. CodY also bound, but with low affinity, to the toxin gene promoters, suggesting that the regulation of toxin gene expression by CodY occurs primarily through direct control of tcdR gene expression. Binding of CodY to the tcdR promoter region was enhanced in the presence of GTP and branched‐chain amino acids, suggesting a link between nutrient limitation and the expression of C. difficile toxin genes.
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Cited by
Clostridium difficile infection: new developments in epidemiology and pathogenesis
Rupnik, M., Wilcox, M. H., & Gerding, D. N. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2164 · Cited by 1,380
Toxin B is essential for virulence of Clostridium difficile
Lyras, D., O’Connor, J. R., Howarth, P. M., Sambol, S. P., Carter, G. P., Phumoonna, T., Poon, R., Adams, V., Vedantam, G., Johnson, S., et al. (2009) · Nature · doi:10.1038/nature07822 · Cited by 745
Peptide Signaling in the Staphylococci
Thoendel, M., Kavanaugh, J. S., Flack, C. E., & Horswill, A. R. (2011) · Chemical Reviews · doi:10.1021/cr100370n · Cited by 438
Carey-Ann, B. D., & Carroll, K. C. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00016-13 · Cited by 423
The role of toxins in Clostridium difficile infection
Chandrasekaran, R., & Lacy, D. B. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux048 · Cited by 353
Metadata
- Authors
- Dineen, S. S., Villapakkam, A. C., Nordman, J. T., & Sonenshein, A. L.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2007-08-28
- Volume
- 66
- Issue
- 1
- Pages
- 206-219
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W1970462201
- Cited by
- 230
- References
- 0
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dineen, S. S., Villapakkam, A. C., Nordman, J. T., & Sonenshein, A. L. (2007). Repression of Clostridium difficile toxin gene expression by CodY. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2007.05906.x
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