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Pseudomonas aeruginosa biofilm matrix polysaccharide Psl is regulated transcriptionally by RpoS and post‐transcriptionally by RsmA
Open accessAbstract
Summary: Extracellular polysaccharides are important components of biofilms. In non‐mucoid Pseudomonas aeruginosa strains, the Pel and Psl polysaccharides are major structural components of the biofilm matrix. In this study, we demonstrate that the alternative σ‐factor RpoS is a positive transcriptional regulator of psl gene expression. Furthermore, we show that psl mRNA has an extensive 5′ untranslated region, to which the post‐transcriptional regulator RsmA binds and represses psl translation. Our observations suggest that upon binding RsmA, the region spanning the ribosome binding site of psl mRNA folds into a secondary stem‐loop structure that blocks the Shine–Dalgarno sequence, preventing ribosome access and protein translation. This constitutes a novel mechanism for translational repression by this family of regulators.
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Cites
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Drenkard, E., & Ausubel, F. M. (2002) · Nature · doi:10.1038/416740a · Cited by 997
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Petrova, O. E., & Sauer, K. (2012) · Journal of Bacteriology · doi:10.1128/jb.00003-12 · Cited by 379
Regulation of Bacterial Virulence by Csr (Rsm) Systems
Vakulskas, C. A., Potts, A. H., Babitzke, P., Ahmer, B. M. M., & Romeo, T. (2015) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00052-14 · Cited by 346
Self-citationPost‐transcriptional regulation on a global scale: form and function of Csr/Rsm systems
Romeo, T., Vakulskas, C. A., & Babitzke, P. (2013) · Environmental Microbiology · doi:10.1111/j.1462-2920.2012.02794.x · Cited by 291
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Metadata
- Authors
- Irie, Y., Starkey, M., Edwards, A. N., Wozniak, D. J., Romeo, T., & Parsek, M. R.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2010-08-02
- Volume
- 78
- Issue
- 1
- Pages
- 158-172
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W1918000672
- Cited by
- 263
- References
- 1
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Irie, Y., Starkey, M., Edwards, A. N., Wozniak, D. J., Romeo, T., & Parsek, M. R. (2010). Pseudomonas aeruginosa biofilm matrix polysaccharide Psl is regulated transcriptionally by RpoS and post‐transcriptionally by RsmA. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2010.07320.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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