The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Post‐transcriptional regulation on a global scale: form and function of Csr/Rsm systems
Open accessAbstract
Summary: Originally described as a repressor of gene expression in the stationary phase of growth, CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation, motility, virulence circuitry of pathogens, quorum sensing and stress response systems by binding to conserved sequences in its target mRNAs and altering their translation and/or turnover. While the binding of CsrA to RNA is understood at an atomic level, new mechanisms of gene activation and repression by this protein are still emerging. In the γ‐proteobacteria, small non‐coding RNAs (sRNAs) use molecular mimicry to sequester multiple CsrA dimers away from mRNA. In contrast, the FliW protein of Bacillus subtilis inhibits CsrA activity by binding to this protein, thereby establishing a checkpoint in flagellum morphogenesis. Turnover of CsrB and CsrC sRNAs in Escherichia coli requires a specificity protein of the GGDEF‐EAL domain superfamily, CsrD, in addition to the housekeeping nucleases RNase E and PNPase. The Csr system of E. coli contains extensive autoregulatory circuitry, which governs the expression and activity of CsrA. Interaction of the Csr system with transcriptional regulatory networks results in a variety of complex response patterns. This minireview will highlight basic principles and new insights into the workings of these complex eubacterial regulatory systems.
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Cites
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Cited by
Life under extreme energy limitation: a synthesis of laboratory- and field-based investigations
Lever, M. A., Rogers, K. L., Lloyd, K. G., Overmann, J., Schink, B., Thauer, R. K., Hoehler, T. M., & Jørgensen, B. B. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv020 · Cited by 378
Regulation of Bacterial Virulence by Csr (Rsm) Systems
Vakulskas, C. A., Potts, A. H., Babitzke, P., Ahmer, B. M. M., & Romeo, T. (2015) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00052-14 · Cited by 346
Self-citationPervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing
Mustoe, A. M., Busan, S., Rice, G. M., Hajdin, C. E., Peterson, B. K., Ruda, V. M., Kubica, N., Nutiu, R., Baryza, J. L., & Weeks, K. M. (2018) · Cell · doi:10.1016/j.cell.2018.02.034 · Cited by 258
Bervoets, I., & Charlier, D. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz001 · Cited by 180
Metadata
- Authors
- Romeo, T., Vakulskas, C. A., & Babitzke, P.
- Venue
- Environmental Microbiology
- Publisher
- Wiley
- Published
- 2012-06-05
- Volume
- 15
- Issue
- 2
- Pages
- 313-324
- ISSN
- 1462-2912 (ISSN-L)
- 1462-2920
- OpenAlex
- W1940073477
- Cited by
- 291
- References
- 86
- FWCI
- 20.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Romeo, T., Vakulskas, C. A., & Babitzke, P. (2013). Post‐transcriptional regulation on a global scale: form and function of Csr/Rsm systems. Environmental Microbiology. https://doi.org/10.1111/j.1462-2920.2012.02794.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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