The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
A novel double‐tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator
Open accessAbstract
Summary: All streptococcal genomes encode the alternative sigma factor SigX and 21 SigX‐dependent proteins required for genetic transformation, yet no pyogenic streptococci are known to develop competence. Resolving this paradox may depend on understanding the regulation of sigX . We report the identification of a regulatory circuit linked to the sigX genes of mutans, pyogenic, and bovis streptococci that uses a novel small, double‐tryptophan‐containing sigX ‐inducing peptide (XIP) pheromone. In all three groups, the XIP gene ( comS ), and sigX have identical, non‐canonical promoters consisting of 9 bp inverted repeats separated from a −10 hexamer by 19 bp. comS is adjacent to a gene encoding a putative transcription factor of the Rgg family and is regulated by its product, which we designate ComR. Deletion of comR or comS in Streptococcus mutans abolished transformability, as did deletion of the oligopeptide permease subunit oppD , suggesting that XIP is imported. Providing S. mutans with synthetic fragments of ComS revealed that seven C‐terminal residues, including the WW motif, cause robust induction of both sigX and the competent state. We propose that this circuit is the proximal regulator of sigX in S. mutans , and we infer that it controls competence in a parallel way in all pyogenic and bovis streptococci.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
EMBOSS: the European molecular biology open software suite.
Rice, P., Longden, I., & Bleasby, A. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02024-2 · Cited by 9,466
I-TASSER: a unified platform for automated protein structure and function prediction
Roy, A., Kucukural, A., & Zhang, Y. (2010) · Nature Protocols · doi:10.1038/nprot.2010.5 · Cited by 6,170
Protein structure prediction on the Web: a case study using the Phyre server
Kelley, L. A., & Sternberg, M. J. E. (2009) · Nature Protocols · doi:10.1038/nprot.2009.2 · Cited by 4,175
von Heijne, G. (1985) · Journal of Molecular Biology · doi:10.1016/0022-2836(85)90046-4 · Cited by 2,166
Bacterial gene transfer by natural genetic transformation in the environment
Lorenz, M. G., & Wackernagel, W. (1994) · Microbiological Reviews · doi:10.1128/mmbr.58.3.563-602.1994 · Cited by 1,412
The regulation of bacterial transcription initiation
Browning, D. F., & Busby, S. J. W. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro787 · Cited by 1,019
DNA uptake during bacterial transformation
Chen, I., & Dubnau, D. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro844 · Cited by 769
Håvarstein, L. S., Coomaraswamy, G., & Morrison, D. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11140 · Cited by 730
Self-citationNatural Genetic Transformation of Streptococcus mutans Growing in Biofilms
Li, Y.-H., Lau, P. C. Y., Lee, J. H., Ellen, R. P., & Cvitkovitch, D. G. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.3.897-908.2001 · Cited by 532
Efficient insertional mutagenesis in lactococci and other gram-positive bacteria
Maguin, E., Prévost, H., Ehrlich, S. D., & Gruss, A. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.3.931-935.1996 · Cited by 486
Cited by
Stress Physiology of Lactic Acid Bacteria.
Papadimitriou, K., Alegría, Á., Bron, P. A., de Angelis, M., Gobbetti, M., Kleerebezem, M., Lemos, J. A., Linares, D. M., Ross, P., Stanton, C., et al. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00076-15 · Cited by 914
The Biology of Streptococcus mutans
Lemos, J. A., Palmer, S. R., Zeng, L., Wen, Z. T., Kajfasz, J. K., Freires, I. A., Abranches, J., & Brady, L. J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0051-2018 · Cited by 794
Bacterial transformation: distribution, shared mechanisms and divergent control
Johnston, C., Martin, B., Fichant, G., Polard, P., & Claverys, J.-P. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3199 · Cited by 731
Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans
Shanker, E., & Federle, M. (2017) · Genes · doi:10.3390/genes8010015 · Cited by 176
Self-citationCommunity Interactions of Oral Streptococci
Jakubovics, N. S., Yassin, S. A., & Rickard, A. H. (2014) · Advances in Applied Microbiology · doi:10.1016/b978-0-12-800261-2.00002-5 · Cited by 107
Metadata
- Authors
- Mashburn‐Warren, L., Morrison, D. A., & Federle, M. J.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2010-09-14
- Volume
- 78
- Issue
- 3
- Pages
- 589-606
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2139222416
- Cited by
- 287
- References
- 63
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A novel double‐tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator. https://app.cochat.ai/papers/10.1111/j.1365-2958.2010.07361.x
- The paper
- Mashburn‐Warren, L., Morrison, D. A., & Federle, M. J. (2010). A novel double‐tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2010.07361.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
