The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
An actin‐based cytoskeleton in archaea
Open accessAbstract
Summary: In eukaryotic and bacterial cells, spatial organization is dependent upon cytoskeletal filaments. Actin is a main eukaryotic cytoskeletal element, involved in key processes such as cell shape determination, mechanical force generation and cytokinesis. We describe an archaeal cytoskeleton which forms helical structures within Pyrobaculum calidifontis cells, as shown by in situ immunostaining. The core components include an archaeal actin homologue, Crenactin, closely related to the eukaryotic counterpart. The crenactin gene belongs to a conserved gene cluster denoted Arcade ( a ctin‐ r elated c ytoskeleton in A rchaea involved in shape de termination). The phylogenetic distribution of arcade genes is restricted to the crenarchaeal Thermoproteales lineage, and to Korarchaeota, and correlates with rod‐shaped and filamentous cell morphologies. Whereas Arcadin‐1, ‐3 and ‐4 form helical structures, suggesting cytoskeleton‐associated functions, Arcadin‐2 was found to be localized between segregated nucleoids in a cell subpopulation, in agreement with possible involvement in cytokinesis. The results support a crenarchaeal origin of the eukaryotic actin cytoskeleton and, as such, have implications for theories concerning the origin of the eukaryotic cell.
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Cites
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“Despite limited sequence similarity between Crenactin and MreB the proteins are, consequently, united by similar functional characteristics, while the phylogenetic analysis revealed that Crenactin evolutionarily is most similar to eukaryotic actins (above; see also Yutin et al., 2009).”
BackgroundInfluentialEvolution of diverse cell division and vesicle formation systems in Archaea
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Spang, A., Saw, J. H., Jørgensen, S. L., Zaremba-Niedzwiedzka, K., Martijn, J., Lind, A. E., van Eijk, R., Schleper, C., Guy, L., & Ettema, T. J. G. (2015) · Nature · doi:10.1038/nature14447 · Cited by 1,324
Self-citationMajor New Microbial Groups Expand Diversity and Alter our Understanding of the Tree of Life
Castelle, C. J., & Banfield, J. F. (2018) · Cell · doi:10.1016/j.cell.2018.02.016 · Cited by 595
An archaeal origin of eukaryotes supports only two primary domains of life
Williams, T. A., Foster, P. G., Cox, C. J., & Embley, T. M. (2013) · Nature · doi:10.1038/nature12779 · Cited by 519
The archaeal ‘TACK’ superphylum and the origin of eukaryotes
Guy, L., & Ettema, T. J. G. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.09.002 · Cited by 347
Self-citationThe evolution of the cytoskeleton
Wickstead, B., & Gull, K. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102065 · Cited by 324
Metadata
- Authors
- Ettema, T. J. G., Lindås, A., & Bernander, R.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2011-04-06
- Volume
- 80
- Issue
- 4
- Pages
- 1052-1061
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2170868227
- Cited by
- 165
- References
- 9
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- green
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