Plasticity of the enteric nervous system during intestinal inflammation
Abstract
Inflammation of the bowel causes structural and functional changes to the enteric nervous system (ENS). While morphological alterations to the ENS are evident in some inflammatory conditions, it appears that relatively subtle modifications to the neurophysiology of enteric microcircuits may play a role in gastrointestinal (GI) dysfunction. These include changes to the excitability and synaptic properties of enteric neurones. The response of the ENS to inflammation varies according to the site and type of inflammation, with the functional consequences depending on the nature of the inflammatory stimulus. It has become clear that inflammation at one site can produce changes that occur at remotes sites in the GI tract. Immunohistochemical data from patients with inflammatory bowel disease (IBD) and animal models indicate that inflammation alters the neurochemical content of some functional classes of enteric neurones. A growing body of evidence supports an active role for enteric glia in neuronal and neuroimmune communication in the GI tract, particularly during inflammation. In conclusion, plasticity of the ENS is a feature of intestinal inflammation. Elucidation of the mechanisms whereby inflammation alters enteric neural control of GI functions may lead to novel treatments for IBD.
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The ENS maintains its capacity to adapt and reorganize its synapses throughout the host's lifetime, similar to synaptic plasticity in the CNS.
“Much like the CNS, the ENS maintains its capacity to adapt and reorganize its synapses throughout the host's lifetime, similar to synaptic plasticity in the CNS (Demir et al., 2013;Lomax et al., 2005).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Lomax et al., 2005
Neuronal plastic changes also occur in the enteric nervous system.
“recently it has become ever more apparent that neuronal plastic changes also occur in the ENS (Demir et al., 2013;Lomax et al., 2005).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Lomax et al., 2005
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Enteric neuropathy in diabetes: Implications for gastrointestinal function
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- Authors
- Lomax, A. E., Fernández, E., & Sharkey, K. A.
- Affiliations
- University of Calgary (CA)
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Sharkey, K. A.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2005-01-04
- Volume
- 17
- Issue
- 1
- Pages
- 4-15
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2050130090
- Cited by
- 205
- References
- 4
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 10 · 2023: 3 · 2022: 5 · 2021: 10 · 2020: 13 · 2019: 11 · 2018: 10 · 2017: 8 · 2016: 11 · 2015: 10 · 2014: 8 · 2013: 13 · 2012: 4
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- enteric nervous system, neuroplasticity, intestinal inflammation, inflammatory bowel disease, neuronal excitability, synaptic properties, neuroimmune interactions, enteric glial cells, neurochemical changes, gastrointestinal dysfunction
- MeSH terms
- Animals, Enteritis, Gastrointestinal Motility, Humans, Neuroglia, Neuronal Plasticity, Inflammatory Bowel Diseases, Enteric Nervous System
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