Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
Open accessAbstract
Background & aims The mechanisms underlying abdominal pain perception in irritable bowel syndrome (IBS) are poorly understood. Intestinal mast cell infiltration may perturb nerve function leading to symptom perception. We assessed colonic mast cell infiltration, mediator release, and spatial interactions with mucosal innervation and their correlation with abdominal pain in IBS patients.Methods IBS patients were diagnosed according to Rome II criteria and abdominal pain quantified according to a validated questionnaire. Colonic mucosal mast cells were identified immunohistochemically and quantified with a computer-assisted counting method. Mast cell tryptase and histamine release were analyzed immunoenzymatically. Intestinal nerve to mast cell distance was assessed with electron microscopy.Results Thirty-four out of 44 IBS patients (77%) showed an increased area of mucosa occupied by mast cells as compared with controls (9.2% +/- 2.5% vs. 3.3 +/- 0.8%, respectively; P < 0.001). There was a 150% increase in the number of degranulating mast cells (4.76 +/- 3.18/field vs. 2.42 +/- 2.26/field, respectively; P = 0.026). Mucosal content of tryptase was increased in IBS and mast cells spontaneously released more tryptase (3.22 +/- 3.48 pmol/min/mg vs. 0.87 +/- 0.65 pmol/min/mg, respectively; P = 0.015) and histamine (339.7 +/- 59.0 ng/g vs. 169.3 +/- 130.6 ng/g, respectively; P = 0.015). Mast cells located within 5 microm of nerve fibers were 7.14 +/- 3.87/field vs. 2.27 +/- 1.63/field in IBS vs. controls (P < 0.001). Only mast cells in close proximity to nerves were significantly correlated with severity and frequency of abdominal pain/discomfort (P < 0.001 and P = 0.003, respectively).Conclusions Colonic mast cell infiltration and mediator release in proximity to mucosal innervation may contribute to abdominal pain perception in IBS patients.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Approximately 70%-84% of patients with irritable bowel syndrome exhibit local mast cell infiltration in their intestinal tissues.
“Notably, approximately 70%–84% of patients with IBS exhibit local mast cell infiltration of mast cells in their intestinal tissues.”
From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [72]
The Mast Cell Counts section reports increased mast-cell-occupied colonic mucosal area in 34 of 44 IBS patients (77.3%), which falls within the claimed range. The paper does not report a 70%–84% range, and its finding concerns colonic mucosa rather than intestinal tissues generally. (LLM, conf=0.85)
Experimental — accuracy not yet measuredMast cell infiltration surrounding intestinal nerves occurs approximately three times more frequently in irritable bowel syndrome patients than in controls, and the number of degranulated mast cells is increased by approximately 1.5-fold.
“Moreover, the phenomenon of mast cell infiltration surrounding intestinal nerves occurs approximately three times more frequently in IBS patients than in controls, and the number of degranulated mast cells is increased by approximately 1.5-fold (72).”
From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [72]
The Mast Cell-Nerve Interactions section reports 7.14 mast cells near nerves per 10 fields in IBS patients versus 2.27 in controls—approximately three times as many. The Mast Cell Degranulation section also reports more degranulating mast cells, but its figures (4.76 versus 2.42) are approximately twofold, not 1.5-fold; the section describes this as a 150% increase. Page numbers were not supplied. (LLM, conf=0.88)
Experimental — accuracy not yet measuredMucosal mast cell degranulation within the gut can affect host intestinal integrity and has been related to visceral pain.
“Mucosal mast cell degranulation within the gut can affect host intestinal integrity (Santos et al., 2001) and has been related to visceral pain (Barbara et al., 2004).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Barbara et al., 2004
The severity and frequency of abdominal pain correlates with the presence of activated mast cells in close proximity to nerve endings in the gut mucosa in some studies, but in others mast cell proliferation associates with a reduction, or no change, in visceral sensitivity.
“The severity and frequency of abdominal pain correlates with the presence of activated mast cells in close proximity to nerve endings in the gut mucosa in some studies, 56 but in others mast cell proliferation associates with a reduction, 57 or no change, 58 in visceral sensitivity.”
From British Society of Gastroenterology guidelines on the management of irritable bowel syndrome (2021) · cites this paper as [56]
An increase in mucosal immune cells including mast cells, macrophages or monocytes, T-cells, and eosinophils has been reported in both pediatric and adult FGID populations.
“An increase in mucosal immune cells including mast cells, macrophages or monocytes, T-cells, and eosinophils has been reported in both pediatric and adult FGID populations79, 113, 114.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [113]
Mast cells were located in closer vicinity to mucosal innervation and correlated with the severity and frequency of abdominal pain in patients with IBS.
“Mast cells were located in closer vicinity to mucosal innervation and correlated with the severity and frequency of abdominal pain in patients with IBS.152”
From Intestinal microbiota in functional bowel disorders: a Rome foundation report (2013) · cites this paper as [152]
Inflammation is present in IBS, as indicated by studies on mast cells and cytokines.
“Studies on mast cells and cytokines point out that inflammation is present in IBS. 2, 13-20”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [13]
Patients with IBS have increased concentrations of inflammatory/immune cells in intestinal tissue compared with controls.
“Evidence supporting this hypothesis includes increased concentrations of inflammatory/immune cells in intestinal tissue from IBS patients, altered levels of pro- and anti-inflammatory cytokines in the GI tract and peripheral blood of patients with IBS (Table 1) (11, 13, 24, 36, 46, 50, 51, 62, 73, 75, 89, 90, 94, 98, 102, 118, 121–124, 168, 174, 185, 187), and IBS-associated polymorphisms in genes”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
Other studies have reported elevated levels of histamine and tryptase release in patients with IBS compared with controls.
“Other studies have reported elevated levels of histamine and tryptase release in patients with IBS compared with controls (11, 13, 35, 73).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
Patients with IBS have altered levels of pro- and anti-inflammatory cytokines in the GI tract and peripheral blood compared with controls.
“Evidence supporting this hypothesis includes increased concentrations of inflammatory/immune cells in intestinal tissue from IBS patients, altered levels of pro- and anti-inflammatory cytokines in the GI tract and peripheral blood of patients with IBS (Table 1) (11, 13, 24, 36, 46, 50, 51, 62, 73, 75, 89, 90, 94, 98, 102, 118, 121–124, 168, 174, 185, 187), and IBS-associated polymorphisms in genes”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
Some studies demonstrated an increase in activated mast cells in biopsies from specific regions of the GI tract (cecum and terminal ileum) but not from other regions, whereas other studies found activated mast cells in the descending colon.
“Notably, some studies demonstrated an increase in activated mast cells in biopsies from specific regions of the GI tract (i.e., cecum and terminal ileum) but not from other regions (e.g., ascending colon, descending colon, rectum) (89, 121, 187), whereas other studies have found activated mast cells in the descending colon (11, 13).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
Several studies have demonstrated increased concentrations of activated mast cells in patients with IBS compared with controls.
“Several studies have demonstrated increased concentrations of activated mast cells in patients with IBS compared with controls (11, 13, 24, 46, 89, 94, 121, 187).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
Activated mast cells were found in close proximity to enteric nerves and correlated with abdominal pain/discomfort in patients with IBS.
“Interestingly, the activated mast cells were found to be in close proximity to enteric nerves and correlated with abdominal pain/discomfort (11).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
In IBS, there is increased infiltration of mast cells in the colonic mucosa in close proximity to enteric nerve fibers and an increased number of sensory nerve fibers surrounding the mast cells.
“At the peripheral level, the close interaction between the immune system and the ENS in IBS is demonstrated by the increased infiltration of mast cells in the colonic mucosa in close proximity to enteric nerve fibers and by the increased number of sensory nerve fibers surrounding the mast cells (2, 11, 13).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
One study demonstrated a strong correlation between the number of infiltrated colonic mast cells around nerves and the severity and frequency of abdominal pain in patients with IBS.
“One study that supports this association demonstrated a strong correlation between number of infiltrated colonic mast cells around nerves and the severity and frequency of abdominal pain in patients with IBS (11).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
Human and animal studies have shown anatomical changes in the enteric nervous system around inflammatory infiltrates in the gut wall.
“In addition, human and animal studies have shown anatomical changes in the enteric nervous system (ENS) around inflammatory infiltrates in the gut wall (2, 11, 13).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [11]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Measurement of protein using bicinchoninic acid
Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., & Klenk, D. C. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90442-7 · Cited by 18,482 · see citing works
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440 · see citing works
Metcalfe, D. D., Baram, D., & Mekori, Y. A. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.4.1033 · Cited by 1,723 · see citing works
Proteinase-activated Receptors
Macfarlane, S. R., Seatter, M. J., Kanke, T., Hunter, G. D., & Plevin, R. J. (2006) · Springer eBooks · doi:10.1007/3-540-29832-0_1335 · Cited by 1,137 · see citing works
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024 · see citing works
Activation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833 · see citing works
The role of psychological and biological factors in postinfective gut dysfunction
Gwee, K.-A., Leong, Y.-L., Graham, C., McKendrick, M. W., Collins, S. M., Walters, S. J., Underwood, J. E., & Read, N. W. (1999) · Gut · doi:10.1136/gut.44.3.400 · Cited by 764 · see citing works
Self-citationInteractions of Mast Cell Tryptase with Thrombin Receptors and PAR-2
Molino, M., Barnathan, E. S., Numerof, R. P., Clark, J., Dreyer, M. L., Cumashi, A., Hoxie, J. A., Schechter, N. M., Woolkalís, M. J., & Brass, L. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4043 · Cited by 591 · see citing works
Effects of gender and sex steroids on the immune response
Schuurs, A. H. W. M., & Verheul, H. A. M. (1990) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(90)90270-3 · Cited by 587 · see citing works
Neal, K. R., Hebden, J., & Spiller, R. (1997) · BMJ · doi:10.1136/bmj.314.7083.779 · Cited by 586 · see citing works
Stead, R. H., Tomioka, M., Quinonez, G. E., Simon, G. T., Felten, S. Y., & Bienenstock, J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.9.2975 · Cited by 554 · see citing works
Törnblom, H., Lindberg, G., Nyberg, B., & Veress, B. (2002) · Gastroenterology · doi:10.1053/gast.2002.37059 · Cited by 516 · see citing works
Collins, S. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70034-3 · Cited by 511 · see citing works
Self-citationIncreased mast cells in the irritable bowel syndrome
O’Sullivan, Clayton, Breslin, Harman, Bountra, Mclaren, & O’Morain (2000) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2000.00221.x · Cited by 480 · see citing works
Psychometric scores and persistence of irritable bowel after infectious diarrhoea
Gwee, K., Read, N. W., Graham, J. C., McKendrick, M. W., Collins, S. M., Marshall, J. S., & Walters, S. J. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90341-4 · Cited by 466 · see citing works
Self-citationProteinase-activated receptor-2 and hyperalgesia: A novel pain pathway
Vergnolle, N., Bunnett, N. W., Sharkey, K. A., Brussee, V., Compton, S. J., Grady, E. F., Cirino, G., Gerard, N. P., Basbaum, A. I., Andrade‐Gordon, P., et al. (2001) · Nature Medicine · doi:10.1038/89945 · Cited by 465 · see citing works
Self-citationMast cells are closely apposed to nerves in the human gastrointestinal mucosa
Stead, R. H., Dixon, M. F., Bramwell, N. H., Riddell, R. H., & Bienenstock, J. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90627-6 · Cited by 445 · see citing works
A Patient Questionnaire to Identify Bowel Disease
Talley, N. J., Phillips, S. F., Melton, L. J., Wiltgen, C., & Zinsmeister, A. R. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-8-671 · Cited by 444 · see citing works
Psychometric scores and persistence of irritable bowel after infectious diarrhoea
Ka, G., Graham, J. C., McKendrick, M. W., Collins, S. M., Marshall, J. S., Walters, S., & Read, N. W. (1996) · African journal of medical practice · Cited by 429 · see citing works
Self-citationSpiller, R. E. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00324-x · Cited by 353 · see citing works
Gender differences in irritable bowel syndrome
Chang, L., & Heitkemper, M. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.36603 · Cited by 351 · see citing works
Management of the irritable bowel syndrome
Camilleri, M. (2001) · Gastroenterology · doi:10.1053/gast.2001.21908 · Cited by 344 · see citing works
Terminal ileal mucosal mast cells in irritable bowel syndrome
Weston, A. P., Biddle, W. L., Bhatia, P. S., & Miner, P. B. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303164 · Cited by 338 · see citing works
Symptom complaints and health care seeking behavior in subjects with bowel dysfunction
Sandler, R. S., Drossman, D. A., Nathan, H. P., & McKee, D. C. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90706-6 · Cited by 326 · see citing works
Symptoms of irritable bowel syndrome in ulcerative colitis in remission
Isgar, B., Harman, M., Kaye, M. D., & Whorwell, P. J. (1983) · Gut · doi:10.1136/gut.24.3.190 · Cited by 274 · see citing works
Mediators and pharmacology of visceral sensitivity: From basic to clinical investigations
Bueno, L. P., Fioramonti, J., Delvaux, M. M., & Frexinos, J. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70056-8 · Cited by 271 · see citing works
A role for inflammation in irritable bowel syndrome?
Barbara, G., GIORGIO, R. D., Stanghellini, V., Cremon, C., & Corinaldesi, R. (2002) · Gut · doi:10.1136/gut.51.suppl_1.i41 · Cited by 266 · see citing works
Self-citationPearce, F. L., Befus, A. D., Gauldie, J., & Bienenstock, J. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.128.6.2481 · Cited by 247 · see citing works
Pearce, F. L., Befus, A. D., & Bienenstock, J. (1984) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(84)90453-6 · Cited by 234 · see citing works
Oral Disodium Cromoglycate in the Treatment of Systemic Mastocytosis
Soter, N. A., Austen, K. F., & Wasserman, S. I. (1979) · New England Journal of Medicine · doi:10.1056/nejm197908303010903 · Cited by 228 · see citing works
The use of multiple-item scales for pain intensity measurement in chronic pain patients
Jensen, M. P., Turner, L. R., Turner, J. A., & Romano, J. M. (1996) · Pain · doi:10.1016/0304-3959(96)03078-3 · Cited by 227 · see citing works
Coelho, A.-M., Vergnolle, N., Guiard, B. P., Fioramonti, J., & Bueno, L. P. (2002) · Gastroenterology · doi:10.1053/gast.2002.32387 · Cited by 212 · see citing works
Symptoms and Visceral Perception in Patients With Pain-Predominant Irritable Bowel Syndrome
Lembo, T., Naliboff, B., Munakata, J., Fullerton, S., Saba, L., Tung, S., Schmulson, M., & Mayer, E. A. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01009.x · Cited by 202 · see citing works
Reed, D. E., Barajas‐Lopez, C., Cottrell, G., Velazquez‐Rocha, S., Dery, O., Grady, E. F., Bunnett, N. W., & Vanner, S. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.032011 · Cited by 192 · see citing works
Self-citationAnorectal sensitivity and responses to rectal distention in patients with ulcerative colitis
Rao, S. S. C., Read, N. W., Davison, P. A., Bannister, J., & Holdsworth, C. D. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90255-1 · Cited by 189 · see citing works
Perceptual responses in patients with inflammatory and functional bowel disease
Chang, L., Munakata, J., Mayer, E. A., Schmulson, M. J., Johnson, T. D., Bernstein, C. N., Saba, L., Naliboff, B., Anton, P. A., & Matin, K. (2000) · Gut · doi:10.1136/gut.47.4.497 · Cited by 185 · see citing works
Role of mast cells in intestinal mucosal function: studies in models of hypersensitivity and stress
Yu, L. C., & Perdue, M. H. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.790107.x · Cited by 152 · see citing works
Stefanini, G. F., Saggioro, A., Alvisi, V., Angelini, G., Capurso, L., Lorenzo, G. D., Dobrilla, G., Dodero, M. C. R., Galimberti, M., Gasbarrini, A., et al. (1995) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529509089786 · Cited by 147 · see citing works
Review article: proteinase‐activated receptors — novel signals for gastrointestinal pathophysiology
Vergnolle, N. (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00690.x · Cited by 135 · see citing works
Symptoms and stool patterns in patients with ulcerative colitis.
Rao, S. S. C., Holdsworth, C. D., & Read, N. W. (1988) · Gut · doi:10.1136/gut.29.3.342 · Cited by 131 · see citing works
Gao, C., Liu, S., Hu, H., Gao, N., Kim, G. Y., Xia, Y. L., & Wood, J. D. (2002) · Gastroenterology · doi:10.1053/gast.2002.36581 · Cited by 106 · see citing works
Proteinase-Activated Receptors
Houle, S., & Hollenberg, M. D. (2007) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.60338-1 · Cited by 96 · see citing works
Kashiba, H., Fukui, H., Morikawa, Y., & Senba, E. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00346-5 · Cited by 92 · see citing works
Mast Cell Degranulation Induces Delayed Rectal Allodynia in Rats: Role of Histamine and 5-HT
Coelho, A.-M., Fioramonti, J., & Bueno, L. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018853728251 · Cited by 86 · see citing works
Neuroimmune interactions in guinea pig stomach and small intestine
Liu, S., Hu, H.-Z., Gao, N., Gao, C., Wang, G., Wang, X., Peck, O. C., Kim, G., Gao, X., Xia, Y., et al. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00241.2002 · Cited by 84 · see citing works
Golytely lavage versus a standard colonoscopy preparation
Pockros, P. J., & Foroozan, P. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90519-0 · Cited by 82 · see citing works
Effect of Substance P on Histamine Secretion from Gut Mucosa in Inflammatory Bowel Disease
Raithel, M. (1999) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655299750026236 · Cited by 77 · see citing works
Neuropathophysiology of Irritable Bowel Syndrome
Wood, J. D. (2002) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200207001-00004 · Cited by 73 · see citing works
Quantification of colonic lamina propria cells by means of a morphometric point-counting method
Lee, E. W., Schiller, L. R., & Fordtran, J. S. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90430-1 · Cited by 70 · see citing works
Gonadal Steroids Regulate the Number and Activational State of Mast Cells in the Medial Habenula1
Wilhelm, M., King, B. G., Silverman, A., & Silver, R. (2000) · Endocrinology · doi:10.1210/endo.141.3.7352 · Cited by 55 · see citing works
Castex, N., Fioramonti, J., JoséFargeas, M., More, J., & Bueno, L. P. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90221-6 · Cited by 46 · see citing works
Effects of prolonged exposure to histamine on guinea pig intestinal neurons
Tamura, K., & Wood, J. D. (1992) · Digestive Diseases and Sciences · doi:10.1007/bf01300291 · Cited by 44 · see citing works
Effect of ovarian hormones on intestinal mast cell reactivity to Substance P
Bradesi, S., Eutamene, H., Theodorou, V., Fioramonti, J., & Bueno, L. (2001) · Life Sciences · doi:10.1016/s0024-3205(00)01008-0 · Cited by 34 · see citing works
Fu, L.-W., Pan, H., & Longhurst, J. C. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.6.h2726 · Cited by 34 · see citing works
Neri, M., Laterza, F., Howell, S. C., Gioacchino, M. D., Festi, D., Ballone, E., Cuccurullo, F., & Talley, N. J. (2000) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200012090-00003 · Cited by 28 · see citing works
Ad, N., Akoev, G. N., Filippova, L. V., Sherman, N. O., Lioudyno, M., & Makarov, F. N. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00377-2 · Cited by 19 · see citing works
Gonadal Steroids Regulate the Number and Activational State of Mast Cells in the Medial Habenula
Wilhelm, M. (2000) · Endocrinology · doi:10.1210/en.141.3.1178 · Cited by 14 · see citing works
Potential Pitfalls in the Differential Diagnosis of Irritable Bowel Syndrome
Smout, A. J. P. M., Azpiroz, F., Coremans, G., Dapoigny, M. C., Collins, S. M., Müller-Lissner, S. A., Pace, F., Stockbrügger, R. W., Vatn, M., & Whorwell, P. J. (2000) · Digestion · doi:10.1159/000007765 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
2 of the 60 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Metcalfe DD, Baram D, Mekori YA. Mast cells. Physiol Rev 1997; 77:1033-1079.
- Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R. Pro- teinase-activated receptors. Pharmacol Rev 2001;53:245-282.
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
The functional gastrointestinal disorders and the Rome III process
Drossman, D. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.008 · Cited by 2,416 · see citing works
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works
Regulation of intestinal epithelial permeability by tight junctions
Suzuki, T. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1070-x · Cited by 1,365 · see citing works
Rajilić–Stojanović, M., Biagi, E., Heilig, H. G. H. J., Kajander, K., Kekkonen, R. A., Tims, S., & de Vos, W. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.043 · Cited by 1,041 · see citing works
Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M. D., Schemann, M., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.14 · Cited by 1,057 · see citing works
Self-citationPostinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024 · see citing works
Brain-gut-microbe communication in health and disease
Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952 · see citing works
Intestinal microbiota in functional bowel disorders: a Rome foundation report
Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939 · see citing works
Self-citationIntestinal barrier function in health and gastrointestinal disease
Camilleri, M., Madsen, K., Spiller, R., Van Meerveld, B. G., & Verne, G. N. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01921.x · Cited by 908 · see citing works
Whorwell, P. J., Altringer, L., Morel, J., Bond, Y., Charbonneau, D., O'Mahony, L., Kiely, B., Shanahan, F., & Quigley, E. M. M. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00734.x · Cited by 799 · see citing works
Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome
Barbara, G., Wang, B., Stanghellini, V., de Giorgio, R., Cremon, C., Di Nardo, G., Trevisani, M., Campi, B., Geppetti, P., Tonini, M., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.039 · Cited by 783 · see citing works
Self-citationSchmulson, M. J., & Drossman, D. A. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16214 · Cited by 788 · see citing works
Role of intestinal microbiota and metabolites on gut homeostasis and human diseases
Lin, L., & Zhang, J. (2017) · BMC Immunology · doi:10.1186/s12865-016-0187-3 · Cited by 731 · see citing works
Bischoff, S. C. (2007) · Nature reviews. Immunology · doi:10.1038/nri2018 · Cited by 620 · see citing works
Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions
Öhman, L., & Simrén, M. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.4 · Cited by 617 · see citing works
Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612 · see citing works
Self-citationHalpin, S. J., & Ford, A. C. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.260 · Cited by 607 · see citing works
Role for protease activity in visceral pain in irritable bowel syndrome
Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29255 · Cited by 591 · see citing works
Self-citationBritish Society of Gastroenterology guidelines on the management of irritable bowel syndrome
Vasant, D. H., Paine, P. A., Black, C. J., Houghton, L. A., Everitt, H. A., Corsetti, M., Agrawal, A., Aziz, I., Farmer, A. D., Eugenicos, M. P., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-324598 · Cited by 547 · see citing works
Piche, T., Barbara, G., Aubert, P., Bruley des Varannes, S., Dainese, R., Nano, J. L., Cremon, C., Stanghellini, V, De Giorgio, R., Galmiche, J. P., et al. (2009) · Gut · doi:10.1136/gut.2007.140806 · Cited by 540 · see citing works
Self-citationAkbar, A., Yiangou, Y., Facer, P., Walters, J. R. F., Anand, P., & Ghosh, S. (2008) · Gut · doi:10.1136/gut.2007.138982 · Cited by 526 · see citing works
The brain-gut axis in abdominal pain syndromes.
Mayer, E. A., & Tillisch, K. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-012309-103958 · Cited by 511 · see citing works
Early weaning stress impairs development of mucosal barrier function in the porcine intestine
Smith, F., Clark, J. E., Overman, B. L., Tozel, C. C., Huang, J. H., Rivier, J., Blikslager, A. T., & Moeser, A. J. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00081.2009 · Cited by 502 · see citing works
Abnormal Intestinal Permeability in Subgroups of Diarrhea-Predominant Irritable Bowel Syndromes
Dunlop, S. P., Hebden, J., Campbell, E., Naesdal, J., Olbe, L., Perkins, A. C., & Spiller, R. C. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00672.x · Cited by 476 · see citing works
FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial
McIntosh, K., Reed, D. E., Schneider, T., Dang, F., Keshteli, A. H., Palma, G. D., Madsen, K. L., Berčík, P., & Vanner, S. J. (2016) · Gut · doi:10.1136/gutjnl-2015-311339 · Cited by 480 · see citing works
Essential Oils: Chemistry and Pharmacological Activities
de Sousa, D. P., Damasceno, R. O. S., Amorati, R., Elshabrawy, H. A., de Castro, R. D., Bezerra, D. P., Nunes, V. R. V., Gomes, R. C., & Lima, T. C. (2023) · Biomolecules · doi:10.3390/biom13071144 · Cited by 468 · see citing works
Moeser, A. J., Pohl, C. S., & Rajput, M. (2017) · Animal nutrition · doi:10.1016/j.aninu.2017.06.003 · Cited by 452 · see citing works
Gasbarrini, A., Corazza, G. R., Gasbarrini, G., Montalto, M., Stefano, M. D., Basilisco, G., Parodi, A., Usai–Satta, P., Satta, P. U., Vernia, P., et al. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.03951.x · Cited by 445 · see citing works
Self-citationKlooker, T. K., Braak, B., Koopman, K. E., Welting, O., Wouters, M. M., der Heide, S. V., Schemann, M., Bischoff, S. C., van den Wijngaard, R. M., & Boeckxstaens, G. E. (2010) · Gut · doi:10.1136/gut.2010.213108 · Cited by 413 · see citing works
Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier
Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718356 · Cited by 420 · see citing works
Self-citationMearin, F., Pérez-Oliveras, M., Juan, A. P., Vinyet, J., Ibañez, A., Coderch, J., & Perona, M. C. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.04.012 · Cited by 406 · see citing works
Extra-intestinal and long term consequences of Giardia duodenalis infections
Halliez, M. C. M. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i47.8974 · Cited by 406 · see citing works
Bonaz, B., Sinniger, V., & Pellissier, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01452 · Cited by 405 · see citing works
Camilleri, M., Lasch, K. L., & Zhou, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00155.2012 · Cited by 397 · see citing works
Grant, A. D., Cottrell, G. S., Amadesi, S., Trevisani, M., Nicoletti, P., Materazzi, S., Altier, C., Cénac, N., Zamponi, G. W., Bautista‐Cruz, F., et al. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.121111 · Cited by 393 · see citing works
Self-citationDiarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum
Guilarte, M., Santos, J., de Torres, I., Alonso, C., Vicario, M., Ramos, L., Martinez, C., Casellas, F., Saperas, E., & Malagelada, J. R. (2007) · Gut · doi:10.1136/gut.2006.100594 · Cited by 385 · see citing works
The mucosal immune system: master regulator of bidirectional gut-brain communications
Powell, N., Walker, M. M., & Talley, N. J. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.191 · Cited by 379 · see citing works
Wouters, M. M., Balemans, D., Van Wanrooy, S., Dooley, J., Cibert-Goton, V., Alpizar, Y. A., Valdez-Morales, E. E., Nasser, Y., Van Veldhoven, P. P., Vanbrabant, W., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.12.034 · Cited by 372 · see citing works
Fundamentals of Neurogastroenterology: Basic Science
Vanner, S. J., Meerveld, B. G., Mawe, G. M., Shea‐Donohue, T., Verdu, E. F., Wood, J. D., & Grundy, D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.018 · Cited by 369 · see citing works
Mast Cells in Inflammation and Disease: Recent Progress and Ongoing Concerns
Galli, S. J., Gaudenzio, N., & Tsai, M. M. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-071719-094903 · Cited by 370 · see citing works
KAJANDER, K., MYLLYLUOMA, E., RAJILIĆ‐STOJANOVIĆ, M., KYRÖNPALO, S., RASMUSSEN, M., JÄRVENPÄÄ, S., ZOETENDAL, E. G., DE VOS, W. M., VAPAATALO, H., & KORPELA, R. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03542.x · Cited by 367 · see citing works
Neuroimaging of the brain–gut axis: From basic understanding to treatment of functional GI disorders
Mayer, E. A., Naliboff, B. D., & Craig, A. D. B. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.026 · Cited by 366 · see citing works
Vivinus-Nébot, M., Frin-Mathy, G., Bzioueche, H., Dainese, R., Bernard, G., Anty, R., Filippi, J., Saint‐Paul, M., Tulić, M. K., Verhasselt, V., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-304066 · Cited by 365 · see citing works
Brain–gut connections in functional GI disorders: Anatomic and physiologic relationships
Jones, M. P., Dilley, J. B., Drossman, D., & Crowell, M. D. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00730.x · Cited by 358 · see citing works
The Utility of Probiotics in the Treatment of Irritable Bowel Syndrome: A Systematic Review
Brenner, D. M., Moeller, M. J., Chey, W. D., & Schoenfeld, P. S. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.25 · Cited by 362 · see citing works
KAJANDER, K., HATAKKA, K., POUSSA, T., FÄRKKILÄ, M., & KORPELA, R. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02579.x · Cited by 361 · see citing works
A role for the gut microbiota in IBS
Collins, S. M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.40 · Cited by 351 · see citing works
Self-citationMechanisms of hypersensitivity in IBS and functional disorders
Azpiroz, F., Bouin, M., Camilleri, M., Mayer, E. A., Poitras, P., Serra, J., & Spiller, R. E. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00875.x · Cited by 353 · see citing works
Buhner, S., Li, Q., Vignali, S., Barbara, G., De Giorgio, R., Stanghellini, V., Cremon, C., Zeller, F., Langer, R., Daniel, H., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.005 · Cited by 351 · see citing works
Self-citationHouse dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation
Serhan, N., Basso, L., Sibilano, R., Petitfils, C., Meixiong, J., Bonnart, C., Reber, L. L., Marichal, T., Starkl, P. M., Cénac, N., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0493-z · Cited by 347 · see citing works
Cremon, C., Gargano, L., Morselli-Labate, A. M., Santini, D., Cogliandro, R. F., De Giorgio, R., Stanghellini, V., Corinaldesi, R., & Barbara, G. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.94 · Cited by 342 · see citing works
Self-citationThe Intestinal Microenvironment and Functional Gastrointestinal Disorders
Barbara, G., Feinle-Bisset, C., Ghoshal, U. C., Santos, J., Vanner, S. J., Vergnolle, N., Zoetendal, E. G., & Quigley, E. M. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.028 · Cited by 335 · see citing works
Self-citationGrundy, D., & Schemann, M. (2005) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000153315.28327.6e · Cited by 327 · see citing works
Interactions Between Commensal Bacteria and Gut Sensorimotor Function in Health and Disease
Barbara, G., Stanghellini, V., Brandi, G., Cremon, C., Nardo, G. D., De Giorgio, R., & Corinaldesi, R. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00230.x · Cited by 325 · see citing works
Self-citationGecse, K., Róka, R., Ferrier, L., Leveque, M., Eutamene, H., Cartier, C., Ait-Belgnaoui, A., Rosztóczy, A., Izbéki, F., Fioramonti, J., et al. (2008) · Gut · doi:10.1136/gut.2007.140210 · Cited by 314 · see citing works
Local immune response to food antigens drives meal-induced abdominal pain
Aguilera-Lizarraga, J., Florens, M. V., Viola, M. F., Jain, P., Decraecker, L., Appeltans, I., Cuende-Estevez, M., Fabre, N., Van Beek, K., Perna, E., et al. (2021) · Nature · doi:10.1038/s41586-020-03118-2 · Cited by 311 · see citing works
Neuroplasticity and dysfunction after gastrointestinal inflammation
Brierley, S. M., & Linden, D. R. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.103 · Cited by 310 · see citing works
The role of mast cells in functional GI disorders
Wouters, M. M., Vicario, M., & Santos, J. (2016) · Gut · doi:10.1136/gutjnl-2015-309151 · Cited by 308 · see citing works
Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia
Bradesi, S., Schwetz, I., Ennes, H. S., Lamy, C. M., Ohning, G., Fanselow, M. S., Pothoulakis, C., McRoberts, J. A., & Mayer, E. A. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00500.2004 · Cited by 307 · see citing works
The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes
Jacobson, A. R., Yang, D., Vella, M., & Chiu, I. M. (2021) · Mucosal Immunology · doi:10.1038/s41385-020-00368-1 · Cited by 313 · see citing works
Biopsychosocial Model of Irritable Bowel Syndrome
Tanaka, Y., Kanazawa, M., Fukudo, S., & Drossman, D. A. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.2.131 · Cited by 305 · see citing works
Knowles, C. H., GIORGIO, R. D., Kapur, R. P., Bruder, E., Farrugia, G., Geboes, K. J., Lindberg, G., Martin, J. E., Meier‐Ruge, W., Milla, P. J., et al. (2010) · Gut · doi:10.1136/gut.2009.200444 · Cited by 304 · see citing works
Inflammatory neuropathies of the enteric nervous system☆
GIORGIO, R. D., Guerrini, S., Barbara, G., Stanghellini, V., Ponti, F. D., Corinaldesi, R., Moses, P. L., Sharkey, K. A., & Mawe, G. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.02.024 · Cited by 303 · see citing works
Self-citationMast cell‐neural interactions contribute to pain and itch
Gupta, K., & Harvima, I. T. (2018) · Immunological Reviews · doi:10.1111/imr.12622 · Cited by 302 · see citing works
Irritable bowel syndrome: a gut microbiota-related disorder?
Bhattarai, Y., Muniz Pedrogo, D. A., & Kashyap, P. C. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00338.2016 · Cited by 294 · see citing works
Luna, R. A., Oezguen, N., Balderas, M., Venkatachalam, A., Runge, J. K., Versalovic, J., Veenstra-VanderWeele, J., Anderson, G. M., Savidge, T., & Williams, K. C. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.11.008 · Cited by 295 · see citing works
Grundy, D., & Schemann, M. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3280287a23 · Cited by 283 · see citing works
Keita, Å. V., & Söderholm, J. D. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01498.x · Cited by 286 · see citing works
Martínez, C., Lobo, B., Pigrau, M., Ramos, L., González-Castro, A. M., Alonso, C., Guilarte, M., Guilá, M., de Torres, I., Azpiroz, F., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-302093 · Cited by 283 · see citing works
Crouzet, L., Gaultier, E., Del'Homme, C., Cartier, C., Delmas, E., Dapoigny, M., Fioramonti, J., & Bernalier‐Donadille, A. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12103 · Cited by 280 · see citing works
Elsenbruch, S. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.010 · Cited by 280 · see citing works
O’Mahony, S. M., Felice, V. D., Nally, K., Savignac, H. M., Claesson, M. J., Scully, P., Woznicki, J., Hyland, N. P., Shanahan, F., Quigley, E. M., et al. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.054 · Cited by 272 · see citing works
Advances in mast cell biology: new understanding of heterogeneity and function
Moon, T. C., Laurent, C. D. S., Morris, K., Marcet, C. T., Yoshimura, T., Sekar, Y., & Befus, A. D. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.136 · Cited by 274 · see citing works
Wallon, C., Yang, P.-C., Keita, Å. V., Ericson, A.-C., McKay, D. M., Sherman, P. M., Perdue, M. H., & Söderholm, J. D. (2007) · Gut · doi:10.1136/gut.2006.117549 · Cited by 267 · see citing works
Irritable bowel syndrome: A clinical review
Soares, R. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i34.12144 · Cited by 266 · see citing works
The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli
Brierley, S. M., Hughes, P. A., Page, A. J., Kwan, K. Y., Martin, C. M., O’Donnell, T. A., Cooper, N. J., Harrington, A. M., Adam, B., Liebregts, T., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.048 · Cited by 266 · see citing works
WALKER, M. M., TALLEY, N. J., PRABHAKAR, M., PENNANEAC’H, C. J., ARO, P., RONKAINEN, J., STORSKRUBB, T., HARMSEN, W. S., ZINSMEISTER, A. R., & AGREUS, L. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.03937.x · Cited by 261 · see citing works
Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis
Anaf, V., Chapron, C., El Nakadi, I., De Moor, V., Simonart, T., & Noël, J.-C. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.03.057 · Cited by 258 · see citing works
Neural plasticity in pancreatitis and pancreatic cancer
Demir, İ. E., Frieß, H., & Ceyhan, G. O. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.166 · Cited by 256 · see citing works
Dysregulation of the hypothalamic‐pituitary‐adrenal (HPA) axis in irritable bowel syndrome
Chang, L., Sundaresh, S., Elliott, J. E., Anton, P. A., Baldi, P., Licudine, A., Mayer, M., Vuong, T., Hirano, M., Naliboff, B. D., et al. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01171.x · Cited by 250 · see citing works
Moeser, A. J., Ryan, K. A., Nighot, P. K., & Blikslager, A. T. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00304.2006 · Cited by 247 · see citing works
Irritable bowel syndrome, the microbiota and the gut-brain axis
Raskov, H., Burcharth, J., Pommergaard, H.-C., & Rosenberg, J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1218585 · Cited by 243 · see citing works
Grundy, L., Erickson, A., & Brierley, S. M. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114525 · Cited by 245 · see citing works
Somatosensory and autonomic neuronal regulation of the immune response
Udit, S., Blake, K. J., & Chiu, I. M. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00555-4 · Cited by 238 · see citing works
Fundamentals of Neurogastroenterology: Basic Science
Grundy, D., Al–Chaer, E. D., Aziz, Q., Collins, S. M., Ke, M., Taché, Y., & Wood, J. D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.060 · Cited by 232 · see citing works
Self-citationLayer, P., Andresen, V., Pehl, C., Allescher, H. ‐., Bischoff, S., Claßen, M., Enck, P., Frieling, T., Haag, S., Holtmann, G., et al. (2011) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0029-1245976 · Cited by 231 · see citing works
Protease inhibition as new therapeutic strategy for GI diseases
Vergnolle, N. (2016) · Gut · doi:10.1136/gutjnl-2015-309147 · Cited by 226 · see citing works
Irritable Bowel Syndrome, Gut Microbiota and Probiotics
Lee, B. J., & Bak, Y. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.3.252 · Cited by 229 · see citing works
Knowles, C., Giorgio, R. D., Kapur, R., Bruder, E., Farrugia, G., Geboes, K., Gershon, M., Hutson, J., Lindberg, G., Martin, J. E., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0527-y · Cited by 221 · see citing works
Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions
Eller-Smith, O. C., Nicol, A. L., & Christianson, J. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00035 · Cited by 227 · see citing works
Martínez, C., Vicario, M., Ramos, L., Lobo, B., Mosquera, J. L., Alonso, C., Sánchez, A., Guilarte, M., Antolín, M., de Torres, I., et al. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.472 · Cited by 214 · see citing works
Physiological and pathophysiological functions of intestinal mast cells
Bischoff, S. C. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0165-4 · Cited by 225 · see citing works
Cremon, C., Carini, G., Wang, B., Vasina, V., Cogliandro, R. F., De Giorgio, R., Stanghellini, V., Grundy, D., Tonini, M., De Ponti, F., et al. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.86 · Cited by 223 · see citing works
Self-citationNew pathophysiological mechanisms in irritable bowel syndrome
Barbara, G., GIORGIO, R. D., Stanghellini, V., Cremon, C., Salvioli, B., & Corinaldesi, R. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02036.x · Cited by 221 · see citing works
Self-citationEndometriosis and Mechanisms of Pelvic Pain
Howard, F. M. (2009) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2009.06.017 · Cited by 218 · see citing works
Winston, J. H., Shenoy, M. M., Medley, D., Naniwadekar, A. S., & Pasricha, P. J. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.11.014 · Cited by 219 · see citing works
Intestinal Mucosal Mast Cells: Key Modulators of Barrier Function and Homeostasis
Albert-Bayo, M., Paracuellos, I., González-Castro, A. M., Rodríguez‐Urrutia, A., Rodríguez-Lagunas, M. J., Alonso, C., Santos, J., & Vicario, M. (2019) · Cells · doi:10.3390/cells8020135 · Cited by 217 · see citing works
Neuroimmune circuits in inter-organ communication
Huh, J. R., & Veiga‐Fernandes, H. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0247-z · Cited by 216 · see citing works
Matricon, J., Méleine, M., Gelot, A., Piche, T., Dapoigny, M. C., Muller, E., & Ardid, D. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12080 · Cited by 216 · see citing works
- Authors
- Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., Collins, S. M., & Corinaldesi, R.
- Affiliations
- University of Bologna (IT)
- University of California, San Francisco (US)
- McMaster University (CA)
- Corresponding author
- Barbara, Giovanni
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 126
- Issue
- 3
- Pages
- 693-702
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1976068711
- Cited by
- 1,475
- References
- 60
- Citations by year
- 2026: 49 · 2025: 39 · 2024: 49 · 2023: 70 · 2022: 64 · 2021: 74 · 2020: 55 · 2019: 44 · 2018: 74 · 2017: 73 · 2016: 77 · 2015: 71 · 2014: 79 · 2013: 66 · 2012: 84
- FWCI
- 56.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 57840, DK 43207, R01DK057840)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- irritable bowel syndrome, mast cells, abdominal pain, colonic mucosa, enteric nerves, mast cell degranulation, tryptase, histamine release, visceral pain perception, mast cell infiltration
- MeSH terms
- Adult, Aged, Cell Count, Colon, Female, Histamine Release, Humans, Immunohistochemistry, Intestinal Mucosa, Male, Mast Cells, Microscopy, Electron, Middle Aged, Nervous System, Serine Endopeptidases, Blotting, Western, Cell Degranulation, Abdominal Pain, Irritable Bowel Syndrome, Tryptases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
