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Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction
Abstract
Abstract Patients with postinfective irritable bowel syndrome and Trichinella spiralis‐infected mice share many features including visceral hypersensitivity and disordered motility. We assessed enterochromaffin (EC) numbers and serotonin transporter (SERT) using National Institute of Health (NIH) female mice studied for up to 56 days post‐T. spiralis infection. The effects of steroid treatment and the T‐cell dependence of the observed responses were assessed by infection of hydrocortisone‐treated or T‐cell receptor knock out [TCR (β×δ) KO] animals. Enterochromaffin cell density in uninfected animals increased from duodenum 10.0 cells mm−2 (5.9–41.0) to colon 61.8. (46.3–162) cells mm−2P < 0.0001. Infection increased duodenal and jejunal counts which rose to 37.3 (22–57.7) cells mm−2 and 50.6 (7–110.8) cells mm−2, respectively, at day 14. Infection significantly reduced jejunal SERT expression, with luminance values falling from 61.0 (45.1–98.3) to a nadir of 11.6 (0–36.0) units at day 9, P < 0.001. Specific deficiencies in all T cells reduced EC hyperplasia and abrogated infection‐induced mastocytosis. Thus infection induced inflammation increases EC numbers, as has been reported in PI‐IBS, and reduces SERT. This may increase mucosal 5HT availability and contribute to the clinical presentation of PI‐IBS.
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“A mechanism of this type might explain the reported upregulation of mucosal serotonin in a mouse model of postinfectious bowel dysfunction.66”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [66]
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Metadata
- Authors
- Wheatcroft, J., Wakelin, D., Smith, A., Mahoney, C. R., Mawe, G., & Spiller, R.
- Affiliations
- University of Nottingham (GB)
- University of Vermont (US)
- Nottingham University Hospitals NHS Trust (GB)
- Corresponding author
- Spiller, R.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2005-11-18
- Volume
- 17
- Issue
- 6
- Pages
- 863-870
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W1993725963
- Cited by
- 205
- References
- 30
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 7 · 2017: 5 · 2016: 11 · 2015: 3 · 2014: 17 · 2013: 9 · 2012: 12
- FWCI
- 11.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK62267, R01DK062267)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- serotonin transporter, post-infectious irritable bowel syndrome, Trichinella spiralis infection, visceral hypersensitivity, gastrointestinal motility disorders, mastocytosis, T cell dependence, cortisol, intestinal inflammation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cell Count, Digestive System, Enterochromaffin Cells, Hydrocortisone, Hyperplasia, Immunohistochemistry, Intestinal Mucosa, Jejunum, Mast Cells, Mice, Inbred C57BL, T-Lymphocytes, Trichinellosis, Mice, Knockout, Serotonin Plasma Membrane Transport Proteins, Mice
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