Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis

Wang, L-H; Fang, X-C; Pan, G-Z

doi:10.1136/gut.2003.021154

Cited by 387Gastrointestinal motility and disordersGut microbiota and healthInflammatory Bowel Disease

Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis

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Wang, L-H, Fang, X-C, Pan, G-Z·2004·Gut

DOI 10.1136/gut.2003.021154PMC PMC1774156

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Abstract

Background and aims: The incidence of irritable bowel syndrome (IBS) or functional bowel disorders (FBD) after bacillary dysentery (BD) has not been extensively evaluated, and little is known of the pathogenesis of post-infective (PI) IBS. Therefore, we investigated the incidence of IBS and FBD in a Chinese patient population who had recovered from BD. To further elucidate its pathogenesis, neuroimmunological changes, including interleukins (IL), mast cells, neuropeptides, and the relationship between mast cells and intestinal nerves, were investigated. Methods: A cohort study of 295 patients who had recovered from BD (shigella identified from stool in 71.4%) and 243 control subjects consisting of patient siblings or spouses who had not been infected with BD were included in the study. All subjects were followed up using questionnaires for 1–2 years to explore the incidence of FBD and IBS, as defined by the Rome II criteria. In 56 cases of IBS (PI and non-PI) from another source, the number of mast cells in biopsy specimens from the intestinal mucosa were stained with antitryptase antibody and counted under light microscopy. Also, the relationship of mast cells to neurone specific enolase (NSE), substance P (SP), 5-hydroxytryptamine (5-HT), or calcitonin gene related peptide positive nerve fibres was observed using double staining with alcian blue and neuropeptide antibodies. In 30 cases of IBS (PI-IBS, n = 15) taken at random from the 56 cases, expression of interleukin (IL)-1α, IL-1β, and IL-1 receptor antagonist (IL-1ra) mRNAs in intestinal mucosa were identified using reverse transcription-polymerase chain reaction. The above results were compared with 12 non-IBS controls. Results: In the BD infected cohort, the incidences of FBD and IBS were 22.4% and 8.1% (in total)–10.2% (among those in who shigella were identified) respectively, which were significantly higher (p<0.01) than the incidences of FBD (7.4%) and IBS (0.8%) in the control cohort. A longer duration of diarrhoea (⩾7 days) was associated with a higher risk of developing FBD (odds ratio 3.49 (95% confidence interval 1.71–7.13)). Expression of IL-1β mRNA in terminal ileum and rectosigmoid mucosa was significantly higher in PI-IBS patients (p<0.01). The number of mast cells in the terminal ileum mucosa in PI-IBS (11.19 (2.83)) and non-PI-IBS patients (10.78 (1.23)) was significantly increased compared with that (6.05 (0.51)) in control subjects (p<0.01). Also, in the terminal ileum and rectosigmoid mucosa of IBS patients, the density of NSE, SP, and 5-HT positively stained nerve fibres increased (p<0.05) and appeared in clusters, surrounding an increased number of mast cells (p<0.01 compared with controls). Conclusions: BD is a causative factor in PI-IBS. The immune and nervous system may both play important roles in the pathogenesis of PI-IBS.

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Several studies have demonstrated increased concentrations of activated mast cells in patients with IBS compared with controls.
“Several studies have demonstrated increased concentrations of activated mast cells in patients with IBS compared with controls (11, 13, 24, 46, 89, 94, 121, 187).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [187]
Some studies demonstrated an increase in activated mast cells in biopsies from specific regions of the GI tract (cecum and terminal ileum) but not from other regions, whereas other studies found activated mast cells in the descending colon.
“Notably, some studies demonstrated an increase in activated mast cells in biopsies from specific regions of the GI tract (i.e., cecum and terminal ileum) but not from other regions (e.g., ascending colon, descending colon, rectum) (89, 121, 187), whereas other studies have found activated mast cells in the descending colon (11, 13).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [187]
Levels of interleukin-1β mRNA may be increased in the small intestine, colon, and rectum of patients with PI-IBS compared with healthy controls.
“Levels of interleukin (IL)-1β mRNA may be increased in the small intestine, colon, and rectum of patients with PI-IBS compared with healthy controls (75, 187), supporting the hypothesis that low-grade inflammation is present in patients with PI-IBS.”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [187]
In patients with PI-IBS, activation of the GI immune system follows acute GI infection.
“The importance of the interaction between the intestinal microbiota and immune system in IBS patients is demonstrated by a few studies in patients with PI-IBS, indicating activation of the GI immune system following the acute GI infection (57, 58, 75, 89, 94, 124, 168, 170, 187)”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [187]

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Postinfectious Irritable Bowel Syndrome-A Meta-Analysis
Halvorson, H. A., Schlett, C. D., & Riddle, M. S. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00654.x · Cited by 352 · see citing works
“This is consistent with the current literature, which suggests that IGE associated with invasive bacterial etiologies and severity of initial infection are important predictors of developing IBS (16, 21).”
Result
Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity
Gecse, K., Róka, R., Ferrier, L., Leveque, M., Eutamene, H., Cartier, C., Ait-Belgnaoui, A., Rosztóczy, A., Izbéki, F., Fioramonti, J., et al. (2008) · Gut · doi:10.1136/gut.2007.140210 · Cited by 314 · see citing works
The role of mast cells in functional GI disorders
Wouters, M. M., Vicario, M., & Santos, J. (2016) · Gut · doi:10.1136/gutjnl-2015-309151 · Cited by 308 · see citing works
The hypersensitivity to colonic distension of <scp>IBS</scp> patients can be transferred to rats through their fecal microbiota
Crouzet, L., Gaultier, E., Del'Homme, C., Cartier, C., Delmas, E., Dapoigny, M., Fioramonti, J., & Bernalier‐Donadille, A. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12103 · Cited by 280 · see citing works
Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome
Barbara, G., Grover, M., Berčík, P., Corsetti, M., Ghoshal, U. C., Öhman, L., & Rajilić-Stojanović, M. D. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.07.011 · Cited by 283 · see citing works
MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome
Zhou, Q., Souba, W. W., Croce, C. M., & Verne, G. N. (2009) · Gut · doi:10.1136/gut.2009.181834 · Cited by 277 · see citing works
Guidelines for the prevention and treatment of travelers’ diarrhea: a graded expert panel report
Riddle, M. S., Connor, B. A., Beeching, N. J., DuPont, H. L., Hamer, D. H., Kozarsky, P. E., Libman, M., Steffen, R. J., Taylor, D. N., Tribble, D. R., et al. (2017) · Journal of Travel Medicine · doi:10.1093/jtm/tax026 · Cited by 275 · see citing works
Irritable bowel syndrome: A clinical review
Soares, R. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i34.12144 · Cited by 266 · see citing works
Fundamentals of Neurogastroenterology: Basic Science
Grundy, D., Al–Chaer, E. D., Aziz, Q., Collins, S. M., Ke, M., Taché, Y., & Wood, J. D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.060 · Cited by 232 · see citing works
Role of Tumor Necrosis Factor-alpha and Interleukin-10 Gene Polymorphisms in Irritable Bowel Syndrome
van der Veek, P. P. J., van den Berg, M., de Kroon, Y. E., Verspaget, H. W., & Masclee, A. A. M. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00257.x · Cited by 217 · see citing works
Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome
Matricon, J., Méleine, M., Gelot, A., Piche, T., Dapoigny, M. C., Muller, E., & Ardid, D. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12080 · Cited by 216 · see citing works
Irritable Bowel Syndrome: Epidemiology, Natural History, Health Care Seeking and Emerging Risk Factors
Cremonini, F., & Talley, N. J. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.02.008 · Cited by 215 · see citing works
Irritable bowel syndrome: Diagnosis and pathogenesis
El‐Salhy, M. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i37.5151 · Cited by 214 · see citing works
The immune system in irritable bowel syndrome
Barbara, G., Cremon, C., Carini, G., Bellacosa, L., Zecchi, L., Giorgio, R. D., Corinaldesi, R., & Stanghellini, V. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.4.349 · Cited by 211 · see citing works
“cells, including tryptase and histamine, have an increased potential to affect neural function.(47,56) The biological significance of mast cells and mediators re-”
Is Irritable Bowel Syndrome a Low-Grade Inflammatory Bowel Disease?
Berčík, P., Verdu, E. F., & Collins, S. M. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.02.007 · Cited by 207 · see citing works
“A recent study confirmed increased IL-1b levels, structural changes in enteric nerves, and increased mast cell counts in biopsies from patients with postinfectious IBS [32].”
Background
Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction
Wheatcroft, J., Wakelin, D., Smith, A., Mahoney, C. R., Mawe, G., & Spiller, R. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00719.x · Cited by 205 · see citing works
Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome
Piche, T., Saint-Paul, M. C., Dainese, R., Marine-Barjoan, E., Iannelli, A., Montoya, M. L., Peyron, J. F., Czerucka, D., Cherikh, F., Filippi, J., et al. (2008) · Gut · doi:10.1136/gut.2007.127068 · Cited by 198 · see citing works
Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review
Ford, A. C., & Talley, N. J. (2011) · Journal of Gastroenterology · doi:10.1007/s00535-011-0379-9 · Cited by 200 · see citing works
Clinical significance of lymph node metastasis in gastric cancer
Deng, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i14.3967 · Cited by 198 · see citing works
Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes
Hughes, P. A., Harrington, A. M., Castro, J., Liebregts, T., Adam, B., Grasby, D. J., Isaacs, N. J., Maldeniya, L., Martin, C. M., Persson, J., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301856 · Cited by 195 · see citing works
Irritable bowel syndrome in developing countries – a disorder of civilization or colonization?
Gwee, K. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00627.x · Cited by 193 · see citing works
Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome
Zhou, Q., Verne, M. L., Fields, J. Z., Lefante, J. J., Basra, S., Salameh, H., & Verne, G. N. (2019) · Gut · doi:10.1136/gutjnl-2017-315136 · Cited by 195 · see citing works
Post-infectious irritable bowel syndrome
Thabane, M. E., & Marshall, J. K. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.3591 · Cited by 194 · see citing works
Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysentery
Marshall, J. K., Thabane, M., Garg, A. X., Clark, W. F., Moayyedi, P., Collins, S. M., & Walkerton Health Study Investigators (2010) · Gut · doi:10.1136/gut.2009.202234 · Cited by 227 · see citing works
Review article: probiotics and prebiotics in irritable bowel syndrome
SPILLER, R. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03750.x · Cited by 190 · see citing works
Role of infection in irritable bowel syndrome
Spiller, R. C. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-006-1925-8 · Cited by 187 · see citing works
Irritable bowel syndrome: Emerging paradigm in pathophysiology
Lee, Y. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i10.2456 · Cited by 186 · see citing works
Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study
Wensaas, K., Langeland, N., Hanevik, K., Mørch, K., Eide, G. E., & Rørtveit, G. (2011) · Gut · doi:10.1136/gutjnl-2011-300220 · Cited by 184 · see citing works
Crosstalk at the mucosal border: importance of the gut microenvironment in IBS
Öhman, L., Törnblom, H., & Simrén, M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.200 · Cited by 181 · see citing works
Functional gastrointestinal disorders and mast cells: implications for therapy
Barbara, G., Stanghellini, V., GIORGIO, R. D., & Corinaldesi, R. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00685.x · Cited by 176 · see citing works
An Update on Post-infectious Irritable Bowel Syndrome: Role of Genetics, Immune Activation, Serotonin and Altered Microbiome
Spiller, R. E., & Lam, C. (2012) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2012.18.3.258 · Cited by 175 · see citing works
Asian consensus on irritable bowel syndrome
Gwee, K., Bak, Y., Ghoshal, U. C., Gonlachanvit, S., Lee, O. Y., Fock, K. M., Chua, A. S. B., Lu, C., Goh, K., Kositchaiwat, C., et al. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06353.x · Cited by 172 · see citing works
The alteration of enterochromaffin cell, mast cell, and lamina propria T lymphocyte numbers in irritable bowel syndrome and its relationship with psychological factors
Lee, K. J., Kim, Y. B., Kim, J. H., Kwon, H. C., Kim, D. K., & Cho, S. W. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05574.x · Cited by 171 · see citing works
Epidemiology of irritable bowel syndrome in Asia: Something old, something new, something borrowed
Gwee, K., Lu, C., & Ghoshal, U. C. (2009) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2009.05984.x · Cited by 171 · see citing works
Immune dysfunction in patients with functional gastrointestinal disorders
Kindt, S., Van Oudenhove, L., Broekaert, D., Kasran, A., Ceuppens, J. L., Bossuyt, X., Fischler, B., & Tack, J. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01220.x · Cited by 165 · see citing works
Symptomatic overlap between irritable bowel syndrome and microscopic colitis
Limsui, D., Pardi, D. S., Camilleri, M., Loftus, E. V., Kammer, P. P., Tremaine, W. J., & Sandborn, W. J. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20059 · Cited by 167 · see citing works
T-Cell Activation in Patients With Irritable Bowel Syndrome
Öhman, L., Isaksson, S., Lindmark, A.-C., Posserud, I., Stotzer, P.-O., Strid, H., Sjövall, H., & Simrén, M. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.116 · Cited by 165 · see citing works
“Furthermore, individuals who develop IBS after an infectious gastroenteritis have increased expression of the proinflammatory cytokine IL-1β mRNA in rectal biopsies (”
Background
Nerve Fiber Outgrowth Is Increased in the Intestinal Mucosa of Patients With Irritable Bowel Syndrome
Dothel, G., Barbaro, M. R., Boudin, H., Vasina, V. I., Cremon, C., Gargano, L., Bellacosa, L., GIORGIO, R. D., Berre‐Scoul, C. L., Aubert, P., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.042 · Cited by 162 · see citing works
“SH-SY5Y cells treated with Hank’s buffer were used as calibrator and relative gene expression was calculated as ∆∆Ct.(23) The levels of GAP43 gene expression were expressed as fold difference (2).”
Method
Colonic immune cells in irritable bowel syndrome: A systematic review and meta‐analysis
Bashashati, M., Moossavi, S., Cremon, C., Barbaro, M. R., Moraveji, S., Talmon, G., Rezaei, N., Hughes, P. A., Bian, Z. X., Choi, C. H., et al. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13192 · Cited by 175 · see citing works
Irritable Bowel Syndrome and Chronic Fatigue 6 Years After Giardia Infection: A Controlled Prospective Cohort Study
Hanevik, K., Wensaas, K., Rørtveit, G., Eide, G. E., Mørch, K., & Langeland, N. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu629 · Cited by 158 · see citing works
“the eliciting gastroenteritis has been shown to be a risk factor for development of PI-IBS [39] and has also been found in this cohort [40].”
New Insights in the Etiology and Pathophysiology of Irritable Bowel Syndrome: Contribution of Neonatal Stress Models
Barreau, F., Ferrier, L., Fioramonti, J., & Bueno, L. P. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e3180db2949 · Cited by 156 · see citing works
“Indeed, in the ileum and rectosigmoid mucosa of IBS patients, the density of neuron specific enolase, substance P, and serotonin positively stained nerve fibers was increased and appeared in clusters, surrounding an increased number of mast cells (74).”
BackgroundResult
New insights into the pathogenesis and pathophysiology of irritable bowel syndrome
Öhman, L., & Simrén, M. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2006.10.014 · Cited by 155 · see citing works
“The incidence of post-infectious IBS after enteric infecion has been reported to vary between 3% to approximately 5% [144,148–155].”
Background
Immune Activation in Irritable Bowel Syndrome: Can Neuroimmune Interactions Explain Symptoms?
Hughes, P. A., Zola, H., Penttila, I., Blackshaw, L. A., Andrews, J. M., & Krumbiegel, D. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.120 · Cited by 147 · see citing works
Intestinal permeability and irritable bowel syndrome
Camilleri, M., & Gorman, H. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00925.x · Cited by 144 · see citing works
Mechanisms Underlying Visceral Hypersensitivity in Irritable Bowel Syndrome
Barbara, G., Cremon, C., GIORGIO, R. D., Dothel, G., Zecchi, L., Bellacosa, L., Carini, G., Stanghellini, V., & Corinaldesi, R. (2011) · Current Gastroenterology Reports · doi:10.1007/s11894-011-0195-7 · Cited by 144 · see citing works
“In the latter, nerve fibers appeared in clusters surrounding an increased number of mast cells [77].”
Background
Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?
O’Malley, D., Quigley, E. M. M., Dinan, T. G., & Cryan, J. F. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.04.009 · Cited by 139 · see citing works
“, 2000) and mast cells (Wang et al., 2004) and the degree of immune activation is linked to the severity of the infective gastroen-”
Background
The Functional–Organic Dichotomy: Postinfectious Irritable Bowel Syndrome and Inflammatory Bowel Disease–Irritable Bowel Syndrome
Grover, M., Herfarth, H. H., & Drossman, D. A. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.08.032 · Cited by 131 · see citing works
A Global Perspective on Irritable Bowel Syndrome
Quigley, E. M. M., Abdel-Hamid, H., Barbara, G., Bhatia, S. J., Boeckxstaens, G. E., GIORGIO, R. D., Delvaux, M. M., Drossman, D. A., Foxx–Orenstein, A. E., Guarner, F., et al. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318247157c · Cited by 131 · see citing works
Long-term alterations of colonic nerve–mast cell interactions induced by neonatal maternal deprivation in rats
Barreau, F., Salvador–Cartier, C., Houdeau, É., Bueno, L. P., & Fioramonti, J. (2008) · Gut · doi:10.1136/gut.2007.126680 · Cited by 130 · see citing works
“Moreover, afferent nerves exert a trophic effect on intestinal mast cells.”
Background
Diarrhea-Predominant Irritable Bowel Syndrome Is Associated With Diverticular Disease: A Population-Based Study
Jung, H., Choung, R. S., Locke, R. G., Schleck, C. D., Zinsmeister, A. R., & Talley, N. J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.621 · Cited by 128 · see citing works
Intestinal immune activation in presumed post‐infectious functional dyspepsia
Kindt, S., Tertychnyy, A. S., Hertogh, G. D., Geboes, K. J., & Tack, J. F. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01299.x · Cited by 126 · see citing works
Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome
Aerssens, J., Camilleri, M., Talloen, W., Thielemans, L., Göhlmann, H. W. H., Van den Wyngaert, I., Thielemans, T., De Hoogt, R., Andrews, C. N., Bharucha, A. E., et al. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.11.012 · Cited by 124 · see citing works
Infection, inflammation, and the irritable bowel syndrome
Spiller, R., & Garsed, K. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.07.007 · Cited by 122 · see citing works
Antibodies to flagellin indicate reactivity to bacterial antigens in IBS patients
Schoepfer, A. M., Schaffer, T., Seibold‐schmid, B., Müller, S., & Seibold, F. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01166.x · Cited by 120 · see citing works
Is Traveler's Diarrhea a Significant Risk Factor for the Development of Irritable Bowel Syndrome? A Prospective Study
Stermer, E., Lubezky, A., Potasman, I., Paster, E., & Lavy, A. (2006) · Clinical Infectious Diseases · doi:10.1086/507540 · Cited by 120 · see citing works
“One study went further and established infection with Shigella species as the cause of postinfectious IBS in 8% of cases [6].”
Background
Applied Principles of Neurogastroenterology: Physiology/Motility Sensation
Kellow, J. E., Azpiroz, F., Delvaux, M. M., Gebhart, G. F., Mertz, H. R., Quigley, E. M. M., & Smout, A. J. P. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.08.061 · Cited by 117 · see citing works
Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome
Ringel, Y., & Maharshak, N. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00207.2012 · Cited by 115 · see citing works
“The importance of the interaction between the intestinal microbiota and immune system in IBS patients is demonstrated by a few studies in patients with PI-IBS, indicating activation of the GI immune system following the acute GI infection (57, 58, 75, 89, 94, 124, 168, 170, 187), and the recent animal studies showing…”
BackgroundResultInfluential
Neuroanatomy of lower gastrointestinal pain disorders
Vermeulen, W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i4.1005 · Cited by 116 · see citing works
New Insights into the Pathogenesis and Pathophysiology of Irritable Bowel Syndrome
Collins, S. M. (1992) · Springer eBooks · doi:10.1007/978-1-4615-3314-6_9 · Cited by 115 · see citing works
Second Asian Consensus on Irritable Bowel Syndrome
Gwee, K., Gonlachanvit, S., Ghoshal, U. C., Chua, A. S. B., Miwa, H., Wu, J. C. Y., Bak, Y., Lee, O. Y., Lu, C., Park, H., et al. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm19041 · Cited by 112 · see citing works
“8% among controls.(75) In a study from Seoul investigating an outbreak of Shigella infection among 181 health-care”
BackgroundSelf-citation
Neuropathophysiology of functional gastrointestinal disorders
Wood, J. D. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i9.1313 · Cited by 111 · see citing works
Recent developments in the pathophysiology of irritable bowel syndrome
El-Salhy, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i25.7621 · Cited by 111 · see citing works
Systematic review: the influence of geography and ethnicity in irritable bowel syndrome
Kang, J. Y. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02396.x · Cited by 110 · see citing works
Postinfectious irritable bowel syndrome: follow-up of a patient cohort of confirmed cases of bacterial infection with Salmonella or Campylobacter: Postinfectious IBS after Salmonella and Campylobacter infection
Schwille-Kiuntke, J., Enck, P., Zendler, C., Krieg, M., Polster, A. V., Klosterhalfen, S., Autenrieth, I. B., Zipfel, S., & Frick, J.-S. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01779.x · Cited by 110 · see citing works
Systematic review of animal models of post-infectious/post-inflammatory irritable bowel syndrome
Qin, H., Wu, J. C. Y., Tong, X.-D., Sung, J. J. �., Xu, H., & Bian, Z. (2010) · Journal of Gastroenterology · doi:10.1007/s00535-010-0321-6 · Cited by 111 · see citing works
Post-infectious irritable bowel syndrome: Mechanistic insights into chronic disturbances following enteric infection
Beatty, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i14.3976 · Cited by 107 · see citing works
Diet in irritable bowel syndrome
El‐Salhy, M., & Gundersen, D. (2015) · Nutrition Journal · doi:10.1186/s12937-015-0022-3 · Cited by 108 · see citing works
“Several types of endocrine cell in all segments of the gastrointestinal tract of IBS patients are abnormal [108-129].”
Background
Mast cell mediation of visceral sensation and permeability in irritable bowel syndrome
Hasler, W. L., Grabauskas, G., Singh, P., & Owyang, C. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14339 · Cited by 105 · see citing works
An Outbreak of Acute Bacterial Gastroenteritis Is Associated With an Increased Incidence of Irritable Bowel Syndrome in Children
Thabane, M., Simunovic, M., Akhtar-Danesh, N., Garg, A. X., Clark, W. F., Collins, S. M., Salvadori, M., & Marshall, J. K. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.74 · Cited by 120 · see citing works
Inflammation in irritable bowel syndrome: Myth or new treatment target?
Sinagra, E., Pompei, G., Tomasello, G., Cappello, F., Morreale, G. C., Amvrosiadis, G., Rossi, F., Monte, A. I. L., Rizzo, A. G., & Raimondo, D. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i7.2242 · Cited by 102 · see citing works
High risk of post‐infectious irritable bowel syndrome in patients with Clostridium difficile infection
Wadhwa, A., Alnahhas, M. F., Dierkhising, R., Patel, R., Kashyap, P., Pardi, D. S., Khanna, S., & Grover, M. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13737 · Cited by 102 · see citing works
Increasing Evidence That Irritable Bowel Syndrome and Functional Gastrointestinal Disorders Have a Microbial Pathogenesis
Carco, C., Young, W., Gearry, R. B., Talley, N. J., McNabb, W. C., & Roy, N. C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00468 · Cited by 97 · see citing works
“Salmonella (McKendrick and Read, 1994), Shigella (Gwee et al., 1999; Wang et al., 2004) or Escherichia coli (Marshall et al.”
Background
Irritable bowel syndrome in Asia: Pathogenesis, natural history, epidemiology, and management
Gwee, K., Ghoshal, U. C., & Chen, M. (2017) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13987 · Cited by 99 · see citing works
Postinfectious Irritable Bowel Syndrome
Ericsson, C. D., Hatz, C., & DuPont, A. W. (2008) · Clinical Infectious Diseases · doi:10.1086/526774 · Cited by 99 · see citing works
“Increased IL-1b expression in the rectosigmoid and ileum has been found in patients with postinfectious IBS following Shigella infection, and normal levels have been seen in patients with IBS without an infectious onset [5].”
Background
Is irritable bowel syndrome an organic disorder?
El‐Salhy, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i2.384 · Cited by 95 · see citing works
Immune dysregulation in the functional gastrointestinal disorders
Keely, S., Walker, M. M., Marks, E., & Talley, N. J. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12548 · Cited by 96 · see citing works
The role of Blastocystis sp. and Dientamoeba fragilis in irritable bowel syndrome: a systematic review and meta-analysis
Rostami, A., Riahi, S. M., Haghighi, A. N., Saber, V., Armon, B., & Tabaei, S. J. S. (2017) · Parasitology Research · doi:10.1007/s00436-017-5535-6 · Cited by 99 · see citing works
“…Tehran, Iran 5 Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran system perception of pain are proposed as potential mechanisms of IBS (Cann et al. 1983; Kassinen et al. 2007; Stanghellini et al. 2002; Tillisch et al. 2011; Wang et al. 2004).”
Background
Post-infectious irritable bowel syndrome
Spiller, R. E., & Campbell, E. (2005) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000194792.36466.5c · Cited by 92 · see citing works
The Role of Eosinophils and Mast Cells in Intestinal Functional Disease
Walker, M. M., Warwick, A., Ung, C. Y., & Talley, N. J. (2011) · Current Gastroenterology Reports · doi:10.1007/s11894-011-0197-5 · Cited by 90 · see citing works
“However, both showed a marked increase in mast cells over controls [ 44 ].”
Background
Tachykinins and tachykinin receptors in the gut, with special reference to NK2 receptors in human
Lecci, A., Capriati, A., Altamura, M., & Maggi, C. A. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.02.014 · Cited by 91 · see citing works
Update on human Campylobacter jejuni infections
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Authors: Wang, L.-H., Fang, X.-C., & Pan, G.-Z.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author: Pan, G-Z
Venue: Gut
Publisher: BMJ
Published: 2004-07-09
Volume: 53
Issue: 8
Pages: 1096-1101
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.2003.021154
PMC: PMC1774156
OpenAlex: W2158018898
Cited by: 387
References: 51
Citations by year: 2026: 5 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 3 · 2021: 9 · 2020: 10 · 2019: 17 · 2018: 17 · 2017: 18 · 2016: 19 · 2015: 19 · 2014: 31 · 2013: 18 · 2012: 23
FWCI: 19.91
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: other-oa
Locations: Gut (publishedVersion, other-oa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords: shigellosis, irritable bowel syndrome, functional bowel disorders, Shigella, mast cells, neuroimmunology, substance P, calcitonin gene-related peptide, serotonin, interleukin-1, interleukin-1 receptor antagonist, intestinal nerves, pathogenesis, diarrhea duration
MeSH terms: Adult, Colonic Diseases, Functional, Diarrhea, Dysentery, Bacillary, Female, Follow-Up Studies, Humans, Interleukin-1, Intestinal Mucosa, Male, Mast Cells, Nerve Fibers, Phosphopyruvate Hydratase, Risk Factors, Serotonin, Substance P, Calcitonin Gene-Related Peptide, Irritable Bowel Syndrome

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Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis

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