Oxytocin reduces satiety scores without affecting the volume of nutrient intake or gastric emptying rate in healthy subjects: Oxytocin and satiety
Abstract
BACKGROUND: Oxytocin is expressed throughout the gastrointestinal tract and is released in response to a fatty meal. Administration of an oxytocin receptor antagonist prolongs the gastric emptying rate. The aim of this study was to examine the effect of oxytocin on gastric accommodation, gastric emptying time, and satiety after food intake. METHODS: Ten healthy subjects participated in a slow satiety drinking test with a liquid meal. Every 5 min the subjects scored their sensation of satiety using a visual analogue scale (VAS) until maximum satiety was reached and the amount of liquid intake was determined. Twelve subjects participated in a gastric emptying test. They were given a standardized meal containing 20 radio-opaque markers, after which fluoroscopy was performed and VAS was scored every hour. Both tests were performed four times during infusions of saline and three different oxytocin concentrations. Blood was collected for oxytocin concentration measurements. KEY RESULTS: There were no differences in the volume of nutrient intake at maximum satiety between the three doses of oxytocin and saline. However, lower satiety scores at maximum satiety were seen after oxytocin infusion (P = 0.031), with 40 mU min(-1) being the most effective dosage (P = 0.013), and this was also true 30 min after finishing the meal (P = 0.032). There was no difference in gastric emptying time between saline and oxytocin. The oxytocin concentration in plasma was increased proportional to the oxytocin infusions. CONCLUSIONS & INFERENCES: Infusion of oxytocin reduces satiety without affecting the volume of nutrient intake or gastric emptying in healthy subjects.
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The assessment of intravenous oxytocin effects is hampered because peripheral oxytocin is not readily transported across the blood-brain barrier.
“The assessment of respective effects of intravenous oxytocin (17) is hampered because peripheral oxytocin is not readily transported across the blood–brain barrier (18).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [17]
Borg reported that in 10 healthy adults, 40 mU/min IV oxytocin, but not 20 mU/min or 80 mU/min, reduced satiety without affecting volume of intake of a liquid meal.
“Borg reported that in 10 healthy adults, 40 mU/min IV oxytocin, but not 20 mU/min or 80 mU/min, reduced satiety without affecting volume of intake of a liquid meal(13).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [13]
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References 31 · Cited by 26
- Authors
- Borg, J., Simrén, M., & Ohlsson, B.
- Affiliations
- Lund University (SE)
- University of Gothenburg (SE)
- Corresponding author
- Borg, J.
- ORCID
- Simrén, M.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2010-09-26
- Volume
- 23
- Issue
- 1
- Pages
- 56-e5
- ISSN
- 1350-1925 (ISSN-L)
- OpenAlex
- W2166166639
- Cited by
- 26
- References
- 31
- Citations by year
- 2022: 3 · 2021: 3 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Crafoordska Stiftelsen
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, satiety, gastric emptying, gastric accommodation, nutrient intake, oxytocin receptor antagonist, gastrointestinal hormone release, food intake regulation
- MeSH terms
- Animals, Energy Intake, Contrast Media, Female, Fluoroscopy, Gastric Emptying, Humans, Male, Oxytocin, Surveys and Questionnaires, Satiation
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