INCREASED DIAMETER OF DEMYELINATED AXONS IN CHRONIC MULTIPLE SCLEROSIS OF THE SPINAL CORD
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Shintaku M., Hirano A. & Llena J. F. (1988) Neuropathology and Applied Neurobiology 14, 505–510 Increased diameter of demyelinated axons in chronic multiple sclerosis of the spinal cord In an autopsied case of chronic multiple sclerosis, many axons in some demyelinated plaques of the spinal cord had remarkably increased diameters and reduced argentophilia. The increase in axonal diameter extended for some distance and was restricted to the demyelinated areas. A review of 22 autopsy cases of chronic multiple sclerosis revealed similar findings in the plaques of the spinal cord in seven cases. They were also noted in the brain but much less frequently. On electron microscopy, the neurofilaments in these enlarged demyelinated axons were not closely packed but were separated by an increased amount of electron–lucent axoplasm. It is thought that this finding may be a manifestation of increased water content in the axoplasm secondary to increased permeability of the demyelinated axolemma.
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Variations of myelin density are expected to contribute to observed patterns of NDI.
“Although altered exchange of water between intra/extra‐axonal space (i.e., permeability)40, 44 may have contributed to the observed patterns of NDI, it is expected that variations of myelin density would also contribute.”
From Neurite dispersion: a new marker of multiple sclerosis spinal cord pathology? (2017) · cites this paper as [40]
The Discussion (page unavailable) links demyelination to axonal swelling and suggests that altered permeability may increase axoplasmic water content. That provides a possible mechanism by which myelin changes could affect a water-based measurement, but the paper does not examine myelin-density variations or NDI patterns. (LLM, conf=0.76)
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Cites
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Prineas, J. W., & Connell, F. (1979) · Annals of Neurology · doi:10.1002/ana.410050105 · Cited by 454 · see citing works
Fine Structural Study of Neurofibrillary Changes in a Family with Amyotrophic Lateral Sclerosis
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Spinal cord lesions in progressive supranuclear palsy: some new observations
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Self-citationGiant axonal neuropathy: A neuropathological study
Kretzschmar, H. A., Berg, B. O., & Davis, R. L. (1987) · Acta Neuropathologica · doi:10.1007/bf00693779
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Research works printed but not linked: 3
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Mitochondrial changes within axons in multiple sclerosis
Mahad, D. J., Ziabreva, I., Campbell, G., Lax, N., White, K., Hanson, P. S., Lassmann, H., & Turnbull, D. M. (2009) · Brain · doi:10.1093/brain/awp046 · Cited by 454 · see citing works
Neurite dispersion: a new marker of multiple sclerosis spinal cord pathology?
Grussu, F., Schneider, T., Tur, C., Yates, R. L., Tachrount, M., Ianuş, A., Yiannakas, M. C., Newcombe, J., Zhang, H., Alexander, D. C., et al. (2017) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.445 · Cited by 291 · see citing works
“In white matter, this may reflect reduced collateral branching or morphological alterations of individual axons.(40) In gray matter, reduced orientation dispersion may imply reduction in the complexity of dendritic arborisations.”
BackgroundReview: Mitochondria and disease progression in multiple sclerosis
Mahad, D., Lassmann, H., & Turnbull, D. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.00987.x · Cited by 193 · see citing works
- Authors
- SHINTAKU, M., HIRANO, A., & LLENA, J. F.
- Affiliations
- Montefiore Medical Center (US)
- Corresponding author
- HIRANO, A.
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 1988-12
- Volume
- 14
- Issue
- 6
- Pages
- 505-510
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W2090126971
- Cited by
- 33
- References
- 5
- Citations by year
- 2025: 1 · 2021: 2 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuropathology and Applied Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Keywords
- multiple sclerosis, spinal cord, demyelination, demyelinated plaques, neurofilaments
- MeSH terms
- Aged, Female, Humans, Multiple Sclerosis, Nerve Fibers, Myelinated, Spinal Cord
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