Review: Mitochondria and disease progression in multiple sclerosis

Mahad, D.; Lassmann, H.; Turnbull, D.

doi:10.1111/j.1365-2990.2008.00987.x

Cited by 193Multiple Sclerosis Research StudiesMitochondrial Function and PathologyPeripheral Neuropathies and Disorders

Review: Mitochondria and disease progression in multiple sclerosis

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Mahad, D., Lassmann, H., Turnbull, D.·2008·Neuropathology and Applied Neurobiology

DOI 10.1111/j.1365-2990.2008.00987.xPMC PMC2981078

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Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Recent evidence suggests that dysfunction of surviving demyelinated axons and axonal degeneration contribute to the progression of MS. We review the evidence for and potential mechanisms of degeneration as well as dysfunction of chronically demyelinated axons in MS with particular reference to mitochondria, the main source of adenosine‐5′‐triphosphate in axons. Besides adenosine‐5′‐triphosphate production, mitochondria play an important role in calcium handling and produce reactive oxygen species. The mitochondrial changes in axons lacking healthy myelin sheaths as well as redistribution of sodium channels suggest that demyelinated axons would be more vulnerable to energy deficit than myelinated axons. A dysfunction of mitochondria in lesions as well as in the normal‐appearing white and grey matter is increasingly recognized in MS and could be an important determinant of axonal dysfunction and degeneration. Mitochondria are a potential therapeutic target in MS.

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Oxidative damage and mitochondrial dysfunction are key features of MS pathology.
“Oxidative damage and mitochondrial dysfunction are key features of MS pathology [277,278,279,280].”
From Ageing, Cellular Senescence and Neurodegenerative Disease (2018) · cites this paper as [278]

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Authors: Mahad, D., Lassmann, H., & Turnbull, D.
Affiliations: Newcastle University (GB)
Medical University of Vienna (AT)
Corresponding author: Mahad, D.
ORCID: Mahad, D.
Lassmann, H.
Turnbull, D.
Venue: Neuropathology and Applied Neurobiology
Publisher: Wiley
Published: 2008-11-12
Volume: 34
Issue: 6
Pages: 577-589
ISSN: 0305-1846 (ISSN-L)
1365-2990
DOI: 10.1111/j.1365-2990.2008.00987.x
PMC: PMC2981078
OpenAlex: W2015016389
Cited by: 193
References: 119
Citations by year: 2026: 5 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 11 · 2021: 6 · 2020: 12 · 2019: 12 · 2018: 9 · 2017: 12 · 2016: 10 · 2015: 20 · 2014: 13 · 2013: 11 · 2012: 19
FWCI: 1.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Neuropathology and Applied Neurobiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: Wellcome Trust (19854)
Austrian Science Fund
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords: multiple sclerosis, mitochondria, axonal degeneration, demyelination, ATP production, calcium handling, reactive oxygen species, negative energy balance, disease progression, normal-appearing white matter, therapeutic target
MeSH terms: Adenosine Triphosphate, Animals, Axons, Demyelinating Diseases, Energy Metabolism, Humans, Mitochondria, Multiple Sclerosis, Myelin Sheath, Nerve Degeneration, Disease Progression

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