Hirano bodies and related neuronal inclusions
Abstract
Hirano bodies are bright eosinophilic intracytoplasmic inclusions which have a highly characteristic crystalloid fine structure. They occur preferentially in the neuronal processes of the CA1 area in Amnion's horn in a wide variety of conditions, especially amyotrophic lateral sclerosis and parkinsonism–dementia complex on Guam, Alzheimer's disease, Pick's disease and ‘normal’ elderly individuals. Hirano bodies contain epitopes of actin, actin–associated proteins, tau, middle molecular weight neurofilaments subunit and a C–terminal fragment of β‐amyloid precursor protein. In addition to the CA1 area of Amnion's horn, they have also been identified in many other areas of the nervous system in humans and various experimental animals. Although usually observed in neurons. Hirano bodies may also be present in other cell types. It is the consensus that Hirano bodies in the pyramidal layer of CA1 originate largely from an age‐related alteration of the microfilamentous system.
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Actin-rich paracrystalline inclusions, so-called Hirano bodies, are found in brain histopathological samples of Alzheimer's disease and related tauopathies.
“In agreement with the disease relevance of the Tau/actin interaction, actin-rich paracrystalline inclusions, so-called Hirano bodies, are found in brain histopathological samples of AD and related tauopathies24, 25.”
From Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau (2017) · cites this paper as [24]
Cites
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Numbers of Hirano bodies in the hippocampus of normal and demented people with Alzheimer's disease
Gibson, P. H., & Tomlinson, B. E. (1977) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(77)90193-9 · Cited by 118 · see citing works
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DeTure, M. A., & Dickson, D. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0333-5 · Cited by 3,329 · see citing works
“Hirano bodies were first described in Parkinson’s disease complex of Guam patients as eosinophilic intracytoplasmic inclusion bodies found in the presence of NFTs and GVDs, but not amyloid plaques [76, 81].”
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- Authors
- Hirano, A.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Hirano, A.
- ORCID
- Hirano, A.
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 1994-02
- Volume
- 20
- Issue
- 1
- Pages
- 3-11
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W2040680390
- Cited by
- 186
- References
- 2
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 7 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 8 · 2013: 9 · 2012: 8
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropathology and Applied Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Hirano bodies, neuronal inclusions, amyotrophic lateral sclerosis, parkinsonism-dementia complex, Alzheimer's disease, Pick's disease, tau protein, neurofilaments, amyloid precursor protein, eosinophilic inclusions
- MeSH terms
- Animals, Inclusion Bodies, Humans, Nervous System, Nervous System Diseases, Neurons
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