The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Immune effector mechanisms in malaria
Abstract
SUMMARY: That humans in endemic areas become immune to malaria offers encouragement to the idea of developing protective vaccines. However natural immunity is relatively inefficient, being bought at the cost of substantial childhood mortality, and current vaccines are only partially protective. Understanding potential targets and mechanisms of protective immunity is important in the development and evaluation of future vaccines. Some of the problems in identifying such targets and mechanisms in humans naturally exposed to malaria may stem from conceptual and methodological issues related to defining who in a population is susceptible, problems in defining immune responsiveness at single time points and issues related to antigenic polymorphism, as well as the failure of many current approaches to examine functional aspects of the immune response. Protective immune responses may be directed to the pre erythrocytic parasite, to the free merozoite of the blood stage parasite or to new antigens induced on the infected red cell surface. Tackling the methodological issues of defining protection and immune response, together with studies that combine functional assays with new approaches such as allelic exchange and gene knock out offer opportunities for better defining key targets and mechanisms.
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Bull, P. C., Lowe, B. S., Kortok, M., Molyneux, C. S., Newbold, C. I., & Marsh, K. (1998) · Nature Medicine · doi:10.1038/nm0398-358 · Cited by 645
Self-citationEvidence for the Involvement of VAR2CSA in Pregnancy-associated Malaria
Salanti, A., Dahlbäck, M., Turner, L., Nielsen, M. A., Barfod, L., Magistrado, P., Jensen, A. T. R., Lavstsen, T., Ofori, M. F., Marsh, K., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041579 · Cited by 604
Self-citationRicke, C. H., Staalsoe, T., Koram, K., Akanmori, B. D., Riley, E. M., Theander, T. G., & Hviid, L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3309 · Cited by 303
Staalsoe, T., Shulman, C. E., Bulmer, J. N., Kawuondo, K., Marsh, K., & Hviid, L. (2004) · The Lancet · doi:10.1016/s0140-6736(03)15386-x · Cited by 288
Self-citationDuffy, P. E., & Fried, M. (2003) · Infection and Immunity · doi:10.1128/iai.71.11.6620-6623.2003 · Cited by 260
Nielsen, M. A., Staalsoe, T., Kurtzhals, J. A. L., Goka, B. Q., Dodoo, D., Alifrangis, M., Theander, T. G., Akanmori, B. D., & Hviid, L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3444 · Cited by 207
Staalsoe, T., Megnekou, R., Fievét, N., Ricke, C. H., Zornig, H. D., Leke, R., Taylor, D. W., Deloron, P., & Hviid, L. (2001) · The Journal of Infectious Diseases · doi:10.1086/322809 · Cited by 161
Newbold, C. I., Pinches, R., Roberts, D. J., & Marsh, K. (1992) · Experimental Parasitology · doi:10.1016/0014-4894(92)90213-t · Cited by 144
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Cited by
Atypical Memory B Cells Are Greatly Expanded in Individuals Living in a Malaria-Endemic Area
Weiss, G. E., Crompton, P. D., Li, S., Walsh, L. A., Moir, S., Traore, B., Kayentao, K., Ongoiba, A., Doumbo, O. K., & Pierce, S. K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901297 · Cited by 470
New Insights into Acquisition, Boosting, and Longevity of Immunity to Malaria in Pregnant Women
Fowkes, F. J., McGready, R., Cross, N. J., Hommel, M., Simpson, J. A., Elliott, S. R., Richards, J. S., Lackovic, K., Viladpai-Nguen, J., Narum, D., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis566 · Cited by 101
Charnaud, S. C., McGready, R., Herten-Crabb, A., Powell, R., Guy, A., Langer, C., Richards, J. S., Gilson, P. R., Chotivanich, K., Tsuboi, T., et al. (2016) · Scientific Reports · doi:10.1038/srep20859 · Cited by 23
Metadata
- Authors
- MARSH, K., & KINYANJUI, S.
- Venue
- Parasite Immunology
- Publisher
- Wiley
- Published
- 2005-12-14
- Volume
- 28
- Issue
- 1-2
- Pages
- 51-60
- ISSN
- 0141-9838 (ISSN-L)
- 1365-3024
- OpenAlex
- W1986159395
- Cited by
- 419
- References
- 8
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
