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Calprotectin‐Mediated Zinc Chelation as a Biostatic Mechanism in Host Defence
Abstract
The S‐100 Ca 2+ binding protein, calprotectin, isolated from neutrophil lysates, has been reported to exhibit zinc reversible biostatic activity in vitro. We verified these findings with C. albicans and investigated whether the growth inhibition resulted from zinc deprivation due to chelation by calprotectin. Calprotectin concentrations of 250 μg/ml significantly inhibited the growth of C. albicans. This was reversed by supplementing culture medium with 10 μM ZnSO 4. Incubation of calprotectin in culture medium for 24 h prior to inoculation significantly reduced the minimum inhibitory concentration. When this latter medium was ultrafiltered to remove the calprotectin and then inoculated with C. albicans, significant growth inhibition was still present: again it was reversed by zinc. These findings implicate zinc chelation as a novel, potentially important host defence function of an abundant neutrophil protein.
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Weinberg, E. D. (1978) · Microbiological Reviews · doi:10.1128/mmbr.42.1.45-66.1978 · Cited by 1,254
Dale, I., Brandtzaeg, P., Fagerhol, M. K., & Scott, H. (1985) · American Journal of Clinical Pathology · doi:10.1093/ajcp/84.1.24 · Cited by 177
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Nutritional immunity beyond iron: a role for manganese and zinc
Kehl-Fie, T. E., & Skaar, E. P. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.11.008 · Cited by 634
Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection
Gläser, R., Harder, J., Lange, H., Bartels, J., Christophers, E., & Schröder, J.-M. (2005) · Nature Immunology · doi:10.1038/ni1142 · Cited by 651
Kehl-Fie, T. E., Chitayat, S., Hood, M. I., Damo, S., Restrepo, N., Garcia, C., Munro, K. A., Chazin, W. J., & Skaar, E. P. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.07.004 · Cited by 419
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Rink, L., & Kirchner, H. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.5.1407s · Cited by 271
Metadata
- Authors
- CLOHESSY, P. A., & GOLDEN, B. E.
- Venue
- Scandinavian Journal of Immunology
- Publisher
- Wiley
- Published
- 1995-11
- Volume
- 42
- Issue
- 5
- Pages
- 551-556
- ISSN
- 0300-9475 (ISSN-L)
- 1365-3083
- OpenAlex
- W2019132845
- Cited by
- 202
- References
- 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CLOHESSY, P. A., & GOLDEN, B. E. (1995). Calprotectin‐Mediated Zinc Chelation as a Biostatic Mechanism in Host Defence. Scandinavian Journal of Immunology. https://doi.org/10.1111/j.1365-3083.1995.tb03695.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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