The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Interleukin‐6 Trans‐Signalling in Chronic Inflammation and Cancer
Abstract
Interleukin‐6 (IL‐6) is a cytokine, which plays an important role in many chronic inflammatory diseases. IL‐6 belongs to a family of 10 cytokines, which all act via receptor complexes containing the cytokine receptor subunit gp130. On cells, IL‐6 first binds to a specific membrane‐bound IL‐6R and the complex of IL‐6 and IL‐6R interacts with gp130 leading to signal initiation. Whereas gp130 is widely expressed throughout the body, the IL‐6R is only found on some cells including hepatocytes and some leucocytes. A soluble form of the IL‐6R is an agonist capable of transmitting signals through interaction with the gp130 protein. In vivo, the IL‐6/soluble IL‐6R complex stimulates several types of target cells, which are unresponsive to IL‐6 alone, as they do not express the membrane‐bound IL‐6R. We have named this process trans‐signalling. We provided evidence that a soluble form of the IL‐6 family signalling receptor subunit gp130 is the natural inhibitor of IL‐6 trans‐signalling responses. We showed that in chronic inflammatory diseases such as inflammatory bowel disease, peritonitis, rheumatoid arthritis, asthma as well as in colon cancer, IL‐6 trans‐signalling is critically involved in the maintenance of the disease state. Moreover, in all these animal models, the progression of the disease can be interrupted by specifically interfering with IL‐6 trans‐signalling using recombinant‐soluble gp130Fc protein. The pathophysiologic mechanisms by which the IL‐6/soluble IL‐6R complex perpetuates the inflammatory state are discussed.
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Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
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Interleukin 6 plays a key role in the development of antigen-induced arthritis
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McGonagle, D., Sharif, K., O'Regan, A., & Bridgewood, C. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102537 · Cited by 1,654
Interleukin-6 signaling pathway in targeted therapy for cancer
Guo, Y., Xu, F., Lu, T., Duan, Z., & Zhang, Z. (2012) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2012.04.007 · Cited by 686
Gao, S. P., Mark, K. G., Leslie, K., Pao, W., Motoi, N., Gerald, W. L., Travis, W. D., Bornmann, W., Veach, D., Clarkson, B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31871 · Cited by 666
Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage
Grivennikov, S. I., & Karin, M. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.140145 · Cited by 560
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Metadata
- Authors
- Scheller, J., Ohnesorge, N., & Rose‐John, S.
- Venue
- Scandinavian Journal of Immunology
- Publisher
- Wiley
- Published
- 2006-04-25
- Volume
- 63
- Issue
- 5
- Pages
- 321-329
- ISSN
- 0300-9475 (ISSN-L)
- 1365-3083
- OpenAlex
- W2099731425
- Cited by
- 297
- References
- 6
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Scheller, J., Ohnesorge, N., & Rose‐John, S. (2006). Interleukin‐6 Trans‐Signalling in Chronic Inflammation and Cancer. Scandinavian Journal of Immunology. https://doi.org/10.1111/j.1365-3083.2006.01750.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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