The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Arabidopsis MAP kinase 4 regulates salicylic acid‐ and jasmonic acid/ethylene‐dependent responses via EDS1 and PAD4
Open accessAbstract
Summary: Arabidopsis MPK4 has been implicated in plant defense regulation because mpk4 knockout plants exhibit constitutive activation of salicylic acid (SA)‐dependent defenses, but fail to induce jasmonic acid (JA) defense marker genes in response to JA. We show here that mpk4 mutants are also defective in defense gene induction in response to ethylene (ET), and that they are more susceptible than wild‐type (WT) to Alternaria brassicicola that induces the ET/JA defense pathway(s). Both SA‐repressing and ET/JA‐(co)activating functions depend on MPK4 kinase activity and involve the defense regulators EDS1 and PAD4, as mutations in these genes suppress de‐repression of the SA pathway and suppress the block of the ET/JA pathway in mpk4. EDS1/PAD4 thus affect SA–ET/JA signal antagonism as activators of SA but as repressors of ET/JA defenses, and MPK4 negatively regulates both of these functions. We also show that the MPK4–EDS1/PAD4 branch of ET defense signaling is independent of the ERF1 transcription factor, and use comparative microarray analysis of ctr1, ctr1/mpk4, mpk4 and WT to show that MPK4 is required for induction of a small subset of ET‐regulated genes. The regulation of some, but not all, of these genes involves EDS1 and PAD4.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
affy—analysis of Affymetrix GeneChip data at the probe level
Gautier, L., Cope, L., Bolstad, B. M., & Irizarry, R. A. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg405 · Cited by 5,218
Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.
Li, C., & Wong, W. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.31 · Cited by 3,133
Kieber, J. J., Rothenberg, M., Roman, G., Feldmann, K. A., & Ecker, J. R. (1993) · Cell · doi:10.1016/0092-8674(93)90119-b · Cited by 1,923
Cao, H., Glazebrook, J., Clarke, J. D., Volko, S., & Dong, X. (1997) · Cell · doi:10.1016/s0092-8674(00)81858-9 · Cited by 1,570
Thomma, B. P. H. J., Eggermont, K., Penninckx, I. A. M. A., Mauch-Mani, B., Vogelsang, R., Cammue, B. P. A., & Broekaert, W. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15107 · Cited by 1,513
Lorenzo, O., Piqueras, R., Sánchez-Serrano, J. J., & Solano, R. (2003) · The Plant Cell · doi:10.1105/tpc.007468 · Cited by 1,405
Salicylic Acid: A Likely Endogenous Signal in the Resistance Response of Tobacco to Viral Infection
Malamy, J., Carr, J. P., Klessig, D. F., & Raskin, I. (1990) · Science · doi:10.1126/science.250.4983.1002 · Cited by 1,370
Coordinated plant defense responses in Arabidopsis revealed by microarray analysis
Schenk, P. M., Kazan, K., Wilson, I., Anderson, J. P., Richmond, T., Somerville, S. C., & Manners, J. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11655 · Cited by 1,370
Lorenzo, O., Chico, J. M., Saénchez-Serrano, J. J., & Solano, R. (2004) · The Plant Cell · doi:10.1105/tpc.022319 · Cited by 1,344
Cited by
Hormonal Modulation of Plant Immunity
Pieterse, C. M. J., Van der Does, D., Zamioudis, C., Leon-Reyes, A., & Van Wees, S. C. M. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154055 · Cited by 2,998
Salicylic acid, a multifaceted hormone to combat disease
Vlot, A. C., Dempsey, D. A., & Klessig, D. F. (2009) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.050908.135202 · Cited by 2,568
Role of plant hormones in plant defence responses
Bari, R., & Jones, J. D. G. (2009) · Plant Molecular Biology · doi:10.1007/s11103-008-9435-0 · Cited by 2,565
Networking by small-molecule hormones in plant immunity
Pieterse, C. M. J., Leon-Reyes, A., Van der Ent, S., & Van Wees, S. C. M. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.164 · Cited by 2,327
Salicylic acid beyond defence: its role in plant growth and development
Rivas-San Vicente, M., & Plasencia, J. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/err031 · Cited by 1,444
Metadata
- Authors
- Brodersen, P., Petersen, M., Bjørn Nielsen, H., Zhu, S., Newman, M., Shokat, K. M., Rietz, S., Parker, J., & Mundy, J.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2006-07-10
- Volume
- 47
- Issue
- 4
- Pages
- 532-546
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W2095962396
- Cited by
- 397
- References
- 61
- FWCI
- 29.82
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Arabidopsis MAP kinase 4 regulates salicylic acid‐ and jasmonic acid/ethylene‐dependent responses via EDS1 and PAD4. https://app.cochat.ai/papers/10.1111/j.1365-313x.2006.02806.x
- The paper
- Brodersen, P., Petersen, M., Bjørn Nielsen, H., Zhu, S., Newman, M., Shokat, K. M., Rietz, S., Parker, J., & Mundy, J. (2006). Arabidopsis MAP kinase 4 regulates salicylic acid‐ and jasmonic acid/ethylene‐dependent responses via EDS1 and PAD4. The Plant Journal. https://doi.org/10.1111/j.1365-313x.2006.02806.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
