Cited by 267Plant Molecular Biology ResearchPlant Parasitism and ResistanceDevelopmental Biology and Gene Regulation

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Dynamics of MONOPTEROS and PIN‐FORMED1 expression during leaf vein pattern formation in Arabidopsis thaliana

Wenzel, Carol L., Schuetz, Mathias, Yu, Qian, Mattsson, Jim·2007·The Plant Journal

DOI 10.1111/j.1365-313x.2006.02977.x

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Abstract

Summary: Genetic evidence links the Arabidopsis MONOPTEROS (MP) and PIN‐FORMED1 (PIN1) genes to the patterning of leaf veins. To elucidate their potential functions and interactions in this process, we have assessed the dynamics of MP and PIN1 expression during vascular patterning in Arabidopsis leaf primordia. Both genes undergo a dynamic process of gradual refinement of expression into files one to two cells wide before overt vascular differentiation. The subcellular distribution of PIN1 is also gradually refined from a non‐polar distribution in isodiametric cells to strongly polarized in elongated procambial cells and provides an indication of overall directions of auxin flow. We found evidence that MP expression can be activated by auxin exposure and that PIN1 as well as DR5::GUS expression is defective in mp mutant leaves. Taken together the results suggest a feedback regulatory loop that involves auxin, MP and PIN1 and provide novel experimental support for the canalization‐of‐auxin‐flow hypothesis.

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Benková, E., Michniewicz, M., Sauer, M., Teichmann, T., Seifertová, D., Jürgens, G., & Friml, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00924-3 · Cited by 2,637
Aux/IAA Proteins Repress Expression of Reporter Genes Containing Natural and Highly Active Synthetic Auxin Response Elements
Ulmasov, T., Murfett, J., Hagen, G., & Guilfoyle, T. J. (1997) · The Plant Cell · doi:10.1105/tpc.9.11.1963 · Cited by 2,086
The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots
Blilou, I., Xu, J., Wildwater, M., Willemsen, V., Paponov, I. A., Friml, J., Heidstra, R., Aida, M., Palme, K. J., & Scheres, B. (2005) · Nature · doi:10.1038/nature03184 · Cited by 2,061
Efflux-dependent auxin gradients establish the apical–basal axis of Arabidopsis
Friml, J., Vieten, A., Sauer, M., Weijers, D., Schwarz, H., Hamann, T., Offringa, R., & Jürgens, G. (2003) · Nature · doi:10.1038/nature02085 · Cited by 1,896
Regulation of Polar Auxin Transport by AtPIN1 in Arabidopsis Vascular Tissue
Gälweiler, L., Guan, C., Müller, A., Wisman, E., Mendgen, K., Yephremov, A., & Palme, K. (1998) · Science · doi:10.1126/science.282.5397.2226 · Cited by 1,530
Regulation of phyllotaxis by polar auxin transport
Reinhardt, D., Pesce, E.-R., Stieger, P., Mandel, T., Baltensperger, K., Bennett, M., Traas, J., Friml, J., & Kuhlemeier, C. (2003) · Nature · doi:10.1038/nature02081 · Cited by 1,523
The Arabidopsis gene MONOPTEROS encodes a transcription factor mediating embryo axis formation and vascular development
Hardtke, C. S., & Berleth, T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1405 · Cited by 1,064
Arabidopsis AUX1 Gene: A Permease-Like Regulator of Root Gravitropism
Bennett, M. J., Marchant, A., Green, H. G., May, S. T., Ward, S. P., Millner, P. A., Walker, A. R., Schulz, B., & Feldmann, K. A. (1996) · Science · doi:10.1126/science.273.5277.948 · Cited by 1,043
PIN Proteins Perform a Rate-Limiting Function in Cellular Auxin Efflux
Petrášek, J., Mravec, J., Bouchard, R., Blakeslee, J. J., Abas, M., Seifertová, D., Wiśniewska, J., Tadele, Z., Kubeš, M., Čovanová, M., et al. (2006) · Science · doi:10.1126/science.1123542 · Cited by 922
Polar PIN Localization Directs Auxin Flow in Plants
Wiśniewska, J., Xu, J., Seifertová, D., Brewer, P. B., Růžička, K., Blilou, I., Rouquié, D., Benková, E., Scheres, B., & Friml, J. (2006) · Science · doi:10.1126/science.1121356 · Cited by 883

Show all 43 references

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Hickey L.J., 1979, Anatomy of the Dicotyledons, 25

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Authors: Wenzel, C. L., Schuetz, M., Yu, Q., & Mattsson, J.
Affiliations: Simon Fraser University (CA)
Corresponding author: Mattsson, Jim
ORCID: Wenzel, Carol L.
Schuetz, Mathias
Yu, Qian
Mattsson, Jim
Venue: The Plant Journal
Publisher: Wiley
Published: 2007-01-08
Volume: 49
Issue: 3
Pages: 387-398
ISSN: 0960-7412 (ISSN-L)
1365-313X
DOI: 10.1111/j.1365-313x.2006.02977.x
OpenAlex: W1601614441
Cited by: 267
References: 43
Citations by year: 2026: 5 · 2025: 10 · 2024: 15 · 2023: 12 · 2022: 13 · 2021: 21 · 2020: 16 · 2019: 10 · 2018: 5 · 2017: 16 · 2016: 17 · 2015: 11 · 2014: 19 · 2013: 13 · 2012: 18
FWCI: 22.65
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Plant Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: MONOPTEROS, vascular patterning, auxin transport, procambium, gene expression dynamics, Arabidopsis thaliana
MeSH terms: DNA-Binding Proteins, Indoleacetic Acids, Mutation, Transcription Factors, Arabidopsis, Gene Expression Regulation, Plant, Gene Expression Regulation, Developmental, Plant Leaves, Plant Epidermis, Body Patterning, Membrane Transport Proteins, Arabidopsis Proteins, Green Fluorescent Proteins

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Dynamics of MONOPTEROS and PIN‐FORMED1 expression during leaf vein pattern formation in Arabidopsis thaliana

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