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Fake antimalarials in Southeast Asia are a major impediment to malaria control: multinational cross‐sectional survey on the prevalence of fake antimalarials
Abstract
Summary: Objective To assess the prevalence of counterfeit antimalarial drugs in Southeast (SE) Asia. Design Cross‐sectional survey. Setting Pharmacies and shops selling antimalarial drugs in Myanmar (Burma), Lao PDR, Vietnam, Cambodia and Thailand. Main outcome measures Proportion of artemisinin derivatives or mefloquine containing drugs of substandard quality. Results Of the 188 tablet packs purchased which were labelled as ‘artesunate’ 53% did not contain any artesunate. All counterfeit artesunate tablets were labelled as manufactured by ‘Guilin Pharma’, and refinements of the fake blisterpacks made them often hard to distinguish from their genuine counterparts. No other artemisinin derivatives were found to be counterfeited. Of the 44 mefloquine samples, 9% contained <10% of the expected amount of active ingredient. Conclusions An alarmingly high proportion of antimalarial drugs bought in pharmacies and shops in mainland SE Asia are counterfeit, and the problem has increased significantly compared with our previous survey in 1999–2000. This is a serious threat to public health in the region.
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Cited by
Discovery, mechanisms of action and combination therapy of artemisinin
Cui, L., & Su, X.-Z. (2009) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.09.68 · Cited by 371
Ozawa, S., Evans, D. R., Bessias, S., Haynie, D. G., Yemeke, T. T., Laing, S. K., & Herrington, J. E. (2018) · JAMA Network Open · doi:10.1001/jamanetworkopen.2018.1662 · Cited by 356
Substandard and counterfeit medicines: a systematic review of the literature
Almuzaini, T., Choonara, I., & Sammons, H. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-002923 · Cited by 286
Malaria in the Greater Mekong Subregion: heterogeneity and complexity.
Cui, L., Yan, G., Sattabongkot, J., Cao, Y., Chen, B., Chen, X., Fan, Q., Fang, Q., Jongwutiwes, S., Parker, D., et al. (2012) · Acta Tropica · doi:10.1016/j.actatropica.2011.02.016 · Cited by 277
Substandard drugs: a potential crisis for public health
Johnston, A., & Holt, D. W. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12298 · Cited by 270
Metadata
- Authors
- Dondorp, A. M., Newton, P. N., Mayxay, M., Van Damme, W., Smithuis, F. M., Yeung, S., Petit, A., Lynam, A. J., Johnson, A., Hien, T. T., McGready, R., Farrar, J. J., Looareesuwan, S., Day, N. P. J., Green, M. D., & White, N. J.
- Venue
- Tropical Medicine & International Health
- Publisher
- Wiley
- Published
- 2004-12
- Volume
- 9
- Issue
- 12
- Pages
- 1241-1246
- ISSN
- 1360-2276 (ISSN-L)
- 1365-3156
- OpenAlex
- W2050832165
- Cited by
- 240
- References
- 0
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Dondorp, A. M., Newton, P. N., Mayxay, M., Van Damme, W., Smithuis, F. M., Yeung, S., Petit, A., Lynam, A. J., Johnson, A., Hien, T. T., McGready, R., Farrar, J. J., Looareesuwan, S., Day, N. P. J., Green, M. D., & White, N. J. (2004). Fake antimalarials in Southeast Asia are a major impediment to malaria control: multinational cross‐sectional survey on the prevalence of fake antimalarials. Tropical Medicine & International Health. https://doi.org/10.1111/j.1365-3156.2004.01342.x
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