The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Substandard drugs: a potential crisis for public health
Open accessAbstract
Poor‐quality medicines present a serious public health problem, particularly in emerging economies and developing countries, and may have a significant impact on the national clinical and economic burden. Attention has largely focused on the increasing availability of deliberately falsified drugs, but substandard medicines are also reaching patients because of poor manufacturing and quality‐control practices in the production of genuine drugs (either branded or generic). Substandard medicines are widespread and represent a threat to health because they can inadvertently lead to healthcare failures, such as antibiotic resistance and the spread of disease within a community, as well as death or additional illness in individuals. This article reviews the different aspects of substandard drug formulation that can occur (for example, pharmacological variability between drug batches or between generic and originator drugs, incorrect drug quantity and presence of impurities). The possible means of addressing substandard manufacturing practices are also discussed. A concerted effort is required on the part of governments, drug manufacturers, charities and healthcare providers to ensure that only drugs of acceptable quality reach the patient.
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Cites
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Cited by
Essential medicines for universal health coverage
Wirtz, V. J., Hogerzeil, H. V., Gray, A. L., Bigdeli, M., de Joncheere, C. P., Ewen, M. A., Gyansa-Lutterodt, M., Jing, S., Luiza, V. L., Mbindyo, R. M., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(16)31599-9 · Cited by 661
Antibiotic stewardship in low- and middle-income countries: the same but different?
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Anti-corruption, transparency and accountability in health: concepts, frameworks, and approaches
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“Furthermore, the consumption of poor quality drugs is characterized by numerous consequences including treatment failure, drug resistance, increased morbidity and mortality.(14) Similarly, the absence of strong drug regulatory authorities and poor quality control practices in some countries have resulted in the availa…”
Background
Metadata
- Authors
- Johnston, A., & Holt, D. W.
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2014-07-21
- Volume
- 78
- Issue
- 2
- Pages
- 218-243
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- OpenAlex
- W1480324092
- Cited by
- 270
- References
- 76
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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