The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Tetracycline and other tetracycline‐derivative staining of the teeth and oral cavity
Abstract
Tetracyclines (TCN) were introduced in 1948 as broad‐spectrum antibiotics that may be used in the treatment of many common infections in children and adults. One of the side‐effects of tetracyclines is incorporation into tissues that are calcifying at the time of their administration. They have the ability to chelate calcium ions and to be incorporated into teeth, cartilage and bone, resulting in discoloration of both the primary and permanent dentitions. This permanent discoloration varies from yellow or gray to brown depending on the dose or the type of the drug received in relation to body weight. Minocycline hydrochloride, a semisynthetic derivative of tetracycline often used for the treatment of acne, has been shown to cause pigmentation of a variety of tissues including skin, thyroid, nails, sclera, teeth, conjunctiva and bone. Adult‐onset tooth discoloration following long‐term ingestion of tetracycline and minocycline has also been reported. The remarkable side‐effect of minocycline on the oral cavity is the singular occurrence of “black bones”, “black or green roots” and blue‐gray to gray hue darkening of the crowns of permanent teeth. The prevalence of tetracycline and minocycline staining is 3–6%. The mechanism of minocycline staining is still unknown. Most of the reviewed literature consisted of case reports; longitudinal clinical trials are necessary to provide more information on the prevalence, severity, etiology and clinical presentation of tetracycline and TCN‐derivative staining in the adult population.
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Cites
The pharmacological basis of therapeutics
Davies, J. E. (2007) · Occupational and Environmental Medicine · doi:10.1136/oem.2007.033902 · Cited by 578
Bone Localization of the Tetracyclines
Milch, R. A., Rall, D. P., & Tobie, J. E. (1957) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/19.1.87 · Cited by 319
Minocycline-Induced Pigmentation: Incidence, Prevention and Management
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Disorders of pigmentation in the oral cavity
Eisen, D. (2000) · Clinics in Dermatology · doi:10.1016/s0738-081x(00)00148-6 · Cited by 157
(6) Minocycline-induced pigmentation
Hutchinson, S., & Burrows, D. (1992) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1992.tb01230.x · Cited by 141
Malluche, H. H., Monier‐Faugere, M., Rush, M. E., & Friedler, R. M. (1986) · Endocrinology · doi:10.1210/endo-119-6-2649 · Cited by 93
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Dental and Oral Discolorations Associated with Minocycline and Other Tetracycline Analogs
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Minocycline staining of the oral cavity
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Cited by
Solomkin, J. S., Mazuski, J. E., Bradley, J. S., Rodvold, K. A., Goldstein, E. J. C., Baron, E. J., O'Neill, P. J., Chow, A. W., Dellinger, E. P., Eachempati, S. R., et al. (2010) · Surgical Infections · doi:10.1089/sur.2009.9930 · Cited by 623
Chakhtouna, H., Benzeid, H., Zari, N., Qaiss, A. E. K., & Bouhfid, R. (2021) · Separation and Purification Technology · doi:10.1016/j.seppur.2021.118592 · Cited by 145
Utari, A., Chonchaiya, W., Rivera, S. M., Schneider, A., Hagerman, R. J., Faradz, S. M. H., Ethell, I. M., & Nguyen, D. V. (2010) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7558-115.5.433 · Cited by 105
New and Emerging Targeted Therapies for Hidradenitis Suppurativa
Markota Čagalj, A., Marinović, B., & Bukvić Mokos, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073753 · Cited by 74
Acne Management Guidelines by the Dermatological Society of Singapore.
(2019) · PubMed Central · Cited by 74
Metadata
- Authors
- Sánchez, A. R., Rogers, R. S., & Sheridan, P. J.
- Venue
- International Journal of Dermatology
- Publisher
- Wiley
- Published
- 2004-04-22
- Volume
- 43
- Issue
- 10
- Pages
- 709-715
- ISSN
- 0011-9059 (ISSN-L)
- 1365-4632
- OpenAlex
- W2128622296
- Cited by
- 355
- References
- 12
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sánchez, A. R., Rogers, R. S., & Sheridan, P. J. (2004). Tetracycline and other tetracycline‐derivative staining of the teeth and oral cavity. International Journal of Dermatology. https://doi.org/10.1111/j.1365-4632.2004.02108.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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