Evidence-based interventions to improve patient compliance with antihypertensive and lipid-lowering medications
Abstract
The MEDLINE database was searched from 1972 to June 2002 to identify studies of interventions designed to improve compliance with antihypertensive or lipid-lowering medications. Studies were required to employ a controlled design, follow patients for >or=6 months and measure compliance by a method other than patient self-report. The literature review yielded 62 studies describing 79 interventions. Overall, 56% of interventions were reported to improve patient compliance. When only those studies meeting minimum criteria for methodological quality were considered, 22 interventions remained and 12 were recommended, because they demonstrated a significant improvement in compliance. Recommended interventions included fixed-dose combination drugs, once-daily or once-weekly dosing schedules, unit-dose packaging, educational counselling by telephone, case management by pharmacists, treatment in pharmacist- or nurse-operated disease management clinics, mailed refill reminders, self-monitoring, dose-tailoring, rewards and various combination strategies. Personalised, patient-focused programs that involved frequent contact with health professionals or a combination of interventions were the most effective at improving compliance. Less-intensive strategies, such as prescribing products that simplify the medication regimen or sending refill reminders, achieved smaller improvements in compliance but may be cost-effective due to their low cost.
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Only 1 in 5 patients has sufficiently high adherence to achieve the benefits observed in clinical trials.
“During the first year of treatment, the average patient has possession of antihypertensive medications only 50% of the time, and only 1 in 5 patients has sufficiently high adherence to achieve the benefits observed in clinical trials.98,99”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [99]
During the first year of treatment, the average patient has possession of antihypertensive medications only 50% of the time.
“During the first year of treatment, the average patient has possession of antihypertensive medications only 50% of the time, and only 1 in 5 patients has sufficiently high adherence to achieve the benefits observed in clinical trials.98,99”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [99]
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- Authors
- Petrilla, A. A., Benner, J. S., Battleman, D. S., Tierce, J. C., & Hazard, E. H.
- Affiliations
- Pfizer (United States) (US)
- ORCID
- Petrilla, A. A.
- Venue
- International Journal of Clinical Practice
- Publisher
- Wiley
- Published
- 2005-11-18
- Volume
- 59
- Issue
- 12
- Pages
- 1441-1451
- ISSN
- 1368-5031 (ISSN-L)
- OpenAlex
- W1641835206
- Cited by
- 89
- References
- 75
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 8
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
- Health Sciences › Health Professions › General Health Professions › Patient-Provider Communication in Healthcare
- Keywords
- medication adherence, antihypertensive drugs, lipid-lowering drugs, fixed-dose combination, once-daily dosing, unit-dose packaging, pharmacist counseling, telephone counseling, self-monitoring, dose tailoring, reward, cost-effectiveness
- MeSH terms
- Ambulatory Care, Antihypertensive Agents, Hypolipidemic Agents, Cardiovascular Diseases, Counseling, Drug Administration Schedule, Drug Packaging, Drug Therapy, Combination, Humans, Medical Records, Patient Compliance, Telephone, Reminder Systems, Case Management
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