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Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin
Open accessAbstract
There is a need for safe medications that can effectively support recovery by treating symptoms of protracted abstinence that may precipitate relapse in alcoholics, e.g. craving and disturbances in sleep and mood. This proof‐of‐concept study reports on the effectiveness of gabapentin 1200 mg for attenuating these symptoms in a non‐treatment‐seeking sample of cue‐reactive, alcohol‐dependent individuals. Subjects were 33 paid volunteers with current Diagnostic and Statistical Manual of Mental Disorders‐IV alcohol dependence and a strength of craving rating 1 SD or greater for alcohol than water cues. Subjects were randomly assigned to gabapentin or placebo for 1 week and then participated in a within‐subjects trial where each was exposed to standardized sets of pleasant, neutral and unpleasant visual stimuli followed by alcohol or water cues. Gabapentin was associated with significantly greater reductions than placebo on several measures of subjective craving for alcohol as well as for affectively evoked craving. Gabapentin was also associated with significant improvement on several measures of sleep quality. Side effects were minimal, and gabapentin effects were not found to resemble any major classes of abused drugs. Results suggest that gabapentin may be effective for treating the protracted abstinence phase in alcohol dependence and that a randomized clinical trial would be an appropriate next step. The study also suggests the value of cue‐reactivity studies as proof‐of‐concept screens for potential antirelapse drugs.
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“In human studies, gabapentin blocked craving in a human laboratory study in non-treatment-seeking AUD subjects (Mason et al., 2009) and was shown to be an effective treatment of AUD in a double-blind placebo-controlled clinical trial (Mason et al., 2014).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Mason et al., 2009
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Cites
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2022) · doi:10.1176/appi.books.9780890425787 · Cited by 23,476
Measuring emotion: The self-assessment manikin and the semantic differential
Bradley, M. M., & Lang, P. J. (1994) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/0005-7916(94)90063-9 · Cited by 9,538
Random-Effects Models for Longitudinal Data
Laird, N. M., & Ware, J. H. (1982) · Biometrics · doi:10.2307/2529876 · Cited by 8,923
Selective Cortical Undercutting As a Means of Modifying and Studying Frontal Lobe Function in Man
Scoville, W. B. (1949) · Journal of neurosurgery · doi:10.3171/jns.1949.6.1.0065 · Cited by 7,374
Sobell, L. C., & Sobell, M. B. (1992) · Measuring Alcohol Consumption · doi:10.1007/978-1-4612-0357-5_3 · Cited by 4,110
Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
SULLIVAN, J. T., SYKORA, K., SCHNEIDERMAN, J., NARANJO, C. A., & SELLERS, E. M. (1989) · British Journal of Addiction · doi:10.1111/j.1360-0443.1989.tb00737.x · Cited by 1,988
Guidelines for Human Electromyographic Research
Fridlund, A. J., & Cacioppo, J. T. (1986) · Psychophysiology · doi:10.1111/j.1469-8986.1986.tb00676.x · Cited by 1,737
Gueorguieva, R., & Krystal, J. H. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.3.310 · Cited by 1,529
Koob, G. F., Sanna, P. P., & Bloom, F. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80557-7 · Cited by 1,026
Martin, W. R., Sloan, J. W., SAPIRA, J. D., & Jasinski, D. R. (1971) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1971122part1245 · Cited by 945
Experimental Design: Procedures for the Behavioral Sciences
Hedayat, A., & Kirk, R. E. (1970) · Biometrics · doi:10.2307/2529119 · Cited by 828
Modeled Variance in Two-Level Models
Snijders, T. A. B., & Bosker, R. (1994) · Sociological Methods & Research · doi:10.1177/0049124194022003004 · Cited by 761
Development and Initial Validation of a Measure of Drinking Urges in Abstinent Alcoholics
Bohn, M. J., Krahn, D. D., & Staehler, B. A. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01554.x · Cited by 641
Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men.
Cooney, N. L., Litt, M. D., Morse, P. A., Bauer, L. O., & al, E. (1997) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.106.2.243 · Cited by 479
Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men.
Cooney, N. L., Litt, M. D., Morse, P. A., Bauer, L. O., & Gaupp, L. (1997) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.106.2.243 · Cited by 479
Pharmacological Treatment of Alcohol Dependence: A Review of the Evidence
Garbutt, J. C., West, S. L., Carey, T. S., Lohr, K. N., & Crews, F. T. (1999) · JAMA · doi:10.1001/jama.281.14.1318 · Cited by 444 · cited 1×
“At the present time, only disulfiram (Antabuse), naltrexone (ReVia, Vivitrol) and acamprosate (Campral) have received US Food and Drug Administration (FDA) approval for treatment of alcohol dependence (for review see e.g. Garbutt et al. 1999).”
(1986) · PubMed · Cited by 439
Testing for Interaction in Multiple Regression
Allison, P. D. (1977) · American Journal of Sociology · doi:10.1086/226510 · Cited by 378
The pharmacological treatment of alcohol dependence.
Swift, R. M. (1997) · PubMed · Cited by 372
SAFTEE: a technique for the systematic assessment of side effects in clinical trials.
Levine, J., & Schooler, N. (1986) · PubMed · Cited by 330
Picture media and emotion: Effects of a sustained affective context
Bradley, M. M., Cuthbert, B. N., & Lang, P. J. (1996) · Psychophysiology · doi:10.1111/j.1469-8986.1996.tb02362.x · Cited by 312
Acamprosate in alcohol dependence: how does it work?
Littleton, J. M. (1995) · Addiction · doi:10.1046/j.1360-0443.1995.90911793.x · Cited by 278
Placebo-Controlled Study of Gabapentin Treatment of Panic Disorder
Pande, A. C., Pollack, M. H., Crockatt, J. G., Greiner, M., Chouinard, G., Lydiard, R. B., Taylor, C. B., Dager, S. R., & Shiovitz, T. M. (2000) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200008000-00011 · Cited by 276
A double-blind, placebo-controlled study of oral nalmefene for alcohol dependence
Mason, B. J., Salvato, F. R., Williams, L. D., Ritvo, E. C., & Cutler, R. B. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.8.719 · Cited by 271
Self-citationReactivity of alcoholics and nonalcoholics to drinking cues.
Monti, P. M., Binkoff, J. A., Abrams, D. B., Zwick, W. R., Nirenberg, T. D., & Liepman, M. R. (1987) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.96.2.122 · Cited by 268
Cognitive social learning and related perspectives on drug craving
NIAURA, R. S. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.4.x · Cited by 222
International Affective Picture System
Bradley, M. M., & Lang, P. J. (2020) · Springer eBooks · doi:10.1007/978-3-319-24612-3_42 · Cited by 215
Neuroprotective and Abstinence-Promoting Effects of Acamprosate: Elucidating the Mechanism of Action
De Witte, P., Littleton, J., Parot, P., & Koob, G. (2005) · CNS Drugs · doi:10.2165/00023210-200519060-00004 · Cited by 201 · cited 1×
“Journal compilation © 2008 Society for the Study of Addiction Addiction Biology, 14, 73–83 attenuate central nervous system (CNS) hyper excitability (Littleton 1995 or De Witte et al. 2005).”
Alcohol cue reactivity and mood induction in male and female alcoholics.
Rubonis, A. V., Colby, S. M., Monti, P. M., Rohsenow, D. J., Gulliver, S. B., & Sirota, A. D. (1994) · Journal of Studies on Alcohol · doi:10.15288/jsa.1994.55.487 · Cited by 191
Naltrexone's Effect on Cue‐Elicited Craving Among Alcoholics in Treatment
Monti, P. M., Rohsenow, D. J., Hutchison, K. E., Swift, R. M., Mueller, T. I., Colby, S. M., Brown, R. A., Gulliver, S. B., Gordon, A. A., & Abrams, D. B. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04361.x · Cited by 188
Comprehensive handbook of drug and alcohol addiction
Miller, N. S. (1991) · Cited by 182
Gabapentin as a Potential Treatment for Anxiety Disorders
Pollack, M. H., Matthews, J., & Scott, E. L. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.7.992 · Cited by 159
Lowman, C., Allen, J., & Stout, R. L. (1996) · Addiction · doi:10.1111/j.1360-0443.1996.tb02327.x · Cited by 157
Young, F. W. (1968) · Systems Research and Behavioral Science · doi:10.1002/bs.3830130412 · Cited by 150
A solution to some dilemmas when testing hypotheses about ordinal interactions.
Bobko, P. (1986) · Journal of Applied Psychology · doi:10.1037/0021-9010.71.2.323 · Cited by 144
Alcohol cue reactivity: effects of detoxification and extended exposure.
Monti, P. M., Rohsenow, D. J., Rubonis, A. V., NIAURA, R. S., Sirota, A. D., Colby, S. M., & Abrams, D. B. (1993) · Journal of Studies on Alcohol · doi:10.15288/jsa.1993.54.235 · Cited by 141
Alcohol withdrawal symptoms and drinking behavior.
Hershon, H. I. (1977) · Journal of Studies on Alcohol · doi:10.15288/jsa.1977.38.953 · Cited by 139
Cognitive social learning and related perspectives on drug craving
NIAURA, R. S. (2000) · Addiction · doi:10.1080/09652140050111726 · Cited by 135
How Many Cravings? Pharmacological Aspects of Craving Treatment in Alcohol Addiction: A Review
Addolorato, G., Abenavoli, L., Leggio, L., & Gasbarrini, A. (2005) · Neuropsychobiology · doi:10.1159/000084161 · Cited by 133
Animal models of craving for ethanol
Koob, G. F. (2000) · Addiction · doi:10.1080/09652140050111663 · Cited by 127
Cellular and behavioral interactions of gabapentin with alcohol dependence
Roberto, M., Gilpin, N. W., O'Dell, L. E., Cruz, M. T., Morse, A. C., Siggins, G. R., & Koob, G. F. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0575-08.2008 · Cited by 126
Does urge to drink predict relapse after treatment?
Rohsenow, D. J., & Monti, P. M. (1999) · PubMed Central · Cited by 126
ZYWIAK, W. H., CONNORS, G. J., MAISTO, S. A., & WESTERBERG, V. S. (1996) · Addiction · doi:10.1111/j.1360-0443.1996.tb02332.x · Cited by 121
Effect of anticonvulsants on nocturnal sleep in epilepsy.
Placidi, F., Diomedi, M., Scalise, A., Marciani, M. G., Romigi, A., & Gigli, G. L. (2000) · PubMed · Cited by 120
Measuring Craving: An Attempt to Connect Subjective Craving with Cue Reactivity
Ooteman, W., Koeter, M. W. J., Vserheul, R., Schippers, G. M., & van den Brink, W. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00019.x · Cited by 94
Animal models of craving for ethanol
Koob, G. F. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.17.x · Cited by 90
Gabapentin Treatment of Mood Disorders
Ghaemi, S. N., Katzow, J. J., Desai, S. P., & Goodwin, F. K. (1998) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v59n0805 · Cited by 88
Gabapentin Treatment for Insomnia Associated With Alcohol Dependence
Karam‐Hage, M., & Brower, K. J. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.151 · Cited by 86
Myrick, H., Anton, R. F., Voronin, K. E., Wang, W., & Henderson, S. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00299.x · Cited by 73
Gender in relation to relapse crisis situations, coping, and outcome among treated alcoholics
Annis, H. M., Sklar, S. M., & Moser, A. E. (1998) · Addictive Behaviors · doi:10.1016/s0306-4603(97)00024-5 · Cited by 72
Mason, B. J., Light, J. M., Escher, T., & Drobes, D. J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1192-x · Cited by 71
Self-citationA Beneficial Effect on Mood in Partial Epilepsy Patients Treated with Gabapentin
Harden, C. L., Lazar, L. M., Pick, L. H., Nikolov, B. G., Goldstein, M. A., Carson, D., Ravdin, L., Kocsis, J. H., & Labar, D. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb00830.x · Cited by 68
The acute effects of gabapentin in combination with alcohol in heavy drinkers
Bisaga, A. M., & Evans, S. M. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.10.008 · Cited by 50
Lowman, C., Allen, J. M., & Stout, R. L. (1996) · Addiction · doi:10.1046/j.1360-0443.91.12s1.16.x · Cited by 45
Dose‐Effect Relationship of Disulfiram in Human Volunteers. I: Clinical Studies
Christensen, J. K., Møller, I. W., Rønsted, P., Angelo, H. R., & Johansson, B. (1991) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1991.tb01215.x · Cited by 37
Adjunctive gabapentin in treatment-resistant depression: a retrospective chart review
Yasmin, S., Carpenter, L. L., Leon, Z., Siniscalchi, J. M., & Price, L. H. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00187-7 · Cited by 36
Zywiak, W. H., Connors, G. J., Maisto, S. A., & Westerberg, V. S. (1996) · Addiction · doi:10.1046/j.1360-0443.91.12s1.2.x · Cited by 34
Importance of sleep restoration in co-morbid disease: effect of anticonvulsants.
Ehrenberg, B. L. (2000) · PubMed · Cited by 29
Gabapentin treatment of the non-refractory bipolar spectrum: an open case series
Ghaemi, S. N., & Goodwin, F. K. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00218-4 · Cited by 26
Gabapentin Leads to Remission of Somatoform Pain Disorder with Major Depression
Maurer, I., Volz, H., & Sauer, H. (1999) · Pharmacopsychiatry · doi:10.1055/s-1999-7958 · Cited by 23
Product-variable models of interaction effects and causal mechanisms
Hargens, L. L. (2008) · Social Science Research · doi:10.1016/j.ssresearch.2008.05.003 · Cited by 11
Research works printed but not linked: 8
- Baker TB, 1987, In, 257
- Cook EW, 1987, Stimulus control and data acquisition for IBM PCs and compatibles, Psychophysiology, 24, 726
- First MB, 1996, Structured Clinical Interview for DSM‐IV Axis I Disorders—Patient Edition (SCID‐I/P, Version 2.0)
- HargensL(2008)Interpreting product—variable models of interaction effects.Soc Sci Res. (In press).
- Marlatt GA, 1985, Relapse Prevention, 71
- Rasbash J, 2000, A User's Guide to MLwiN
- Singleton EG, 1994, Alcohol Craving Questionnaire: ACQ‐Now: Background and Administration Manual
- Skinner H, 1984, Alcohol Dependence Scale: User's Guide
Cited by
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Witkiewitz, K. A., Litten, R. Z., & Leggio, L. (2019) · Science Advances · doi:10.1126/sciadv.aax4043 · Cited by 629
Angarita, G. A., Emadi, N., Hodges, S. E., & MORGAN, P. T. (2016) · Addiction Science & Clinical Practice · doi:10.1186/s13722-016-0056-7 · Cited by 376
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337
Gabapentin Treatment for Alcohol Dependence: A Randomized Clinical Trial
Mason, B. J., Quello, S., Goodell, V., Shadan, F., Kyle, M., & Begovic, A. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.11950 · Cited by 340
Self-citationMason, B. J., Crean, R., Goodell, V., Light, J. M., Quello, S., Shadan, F., Buffkins, K., Kyle, M., Adusumalli, M., Begovic, A., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.14 · Cited by 242
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Metadata
- Authors
- Mason, B. J., Light, J. M., Williams, L. D., & Drobes, D. J.
- Affiliations
- Scripps Research Institute (US)
- Oregon Research Institute (US)
- University of Miami (US)
- University of South Florida (US)
- Corresponding author
- Mason, Barbara J.
- ORCID
- Light, John M.
- Venue
- Addiction Biology
- Publisher
- Wiley
- Published
- 2008-12-04
- Volume
- 14
- Issue
- 1
- Pages
- 73-83
- ISSN
- 1355-6215 (ISSN-L)
- 1369-1600
- PMC
- PMC2758315
- OpenAlex
- W1924646378
- Cited by
- 115
- References
- 63
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 12 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 6 · 2013: 3 · 2012: 5
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Addiction Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA012602)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- gabapentin, alcoholism, protracted abstinence, alcohol craving, cue reactivity, relapse prevention, sleep quality, mood
- MeSH terms
- Gabapentin, Adult, Affect, Alcohol Deterrents, Alcohol Withdrawal Delirium, Alcoholism, Amines, Arousal, Cues, Cyclohexanecarboxylic Acids, Electromyography, Female, gamma-Aminobutyric Acid, Galvanic Skin Response, Heart Rate, Humans, Male, Middle Aged, Motivation, Pain Measurement, Sleep, Temperance, Treatment Outcome, Secondary Prevention
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