The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin
Open accessAbstract
There is a need for safe medications that can effectively support recovery by treating symptoms of protracted abstinence that may precipitate relapse in alcoholics, e.g. craving and disturbances in sleep and mood. This proof‐of‐concept study reports on the effectiveness of gabapentin 1200 mg for attenuating these symptoms in a non‐treatment‐seeking sample of cue‐reactive, alcohol‐dependent individuals. Subjects were 33 paid volunteers with current Diagnostic and Statistical Manual of Mental Disorders‐IV alcohol dependence and a strength of craving rating 1 SD or greater for alcohol than water cues. Subjects were randomly assigned to gabapentin or placebo for 1 week and then participated in a within‐subjects trial where each was exposed to standardized sets of pleasant, neutral and unpleasant visual stimuli followed by alcohol or water cues. Gabapentin was associated with significantly greater reductions than placebo on several measures of subjective craving for alcohol as well as for affectively evoked craving. Gabapentin was also associated with significant improvement on several measures of sleep quality. Side effects were minimal, and gabapentin effects were not found to resemble any major classes of abused drugs. Results suggest that gabapentin may be effective for treating the protracted abstinence phase in alcohol dependence and that a randomized clinical trial would be an appropriate next step. The study also suggests the value of cue‐reactivity studies as proof‐of‐concept screens for potential antirelapse drugs.
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“In human studies, gabapentin blocked craving in a human laboratory study in non-treatment-seeking AUD subjects (Mason et al., 2009) and was shown to be an effective treatment of AUD in a double-blind placebo-controlled clinical trial (Mason et al., 2014).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Mason et al., 2009
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Metadata
- Authors
- Mason, B. J., Light, J. M., Williams, L. D., & Drobes, D. J.
- Affiliations
- Scripps Research Institute (US)
- Oregon Research Institute (US)
- University of Miami (US)
- University of South Florida (US)
- Corresponding author
- Mason, Barbara J.
- ORCID
- Light, John M.
- Venue
- Addiction Biology
- Publisher
- Wiley
- Published
- 2008-12-04
- Volume
- 14
- Issue
- 1
- Pages
- 73-83
- ISSN
- 1355-6215 (ISSN-L)
- 1369-1600
- PMC
- PMC2758315
- OpenAlex
- W1924646378
- Cited by
- 115
- References
- 63
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 12 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 6 · 2013: 3 · 2012: 5
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Addiction Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA012602)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- gabapentin, alcoholism, protracted abstinence, alcohol craving, cue reactivity, relapse prevention, sleep quality, mood
- MeSH terms
- Gabapentin, Adult, Affect, Alcohol Deterrents, Alcohol Withdrawal Delirium, Alcoholism, Amines, Arousal, Cues, Cyclohexanecarboxylic Acids, Electromyography, Female, gamma-Aminobutyric Acid, Galvanic Skin Response, Heart Rate, Humans, Male, Middle Aged, Motivation, Pain Measurement, Sleep, Temperance, Treatment Outcome, Secondary Prevention
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