The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Rab GTPases and Myosin Motors in Organelle Motility
Abstract
The actin cytoskeleton is essential to ensure the proper location of, and communication between, intracellular organelles. Some actin‐based myosin motors have been implicated in this process, particularly members of the class V myosins. We discuss here the emerging role of the Ras‐like GTPases of the Rab family as regulators of myosin function in organelle transport. Evidence from yeast secretory vesicles and mitochondria, and mammalian melanosomes and endosomes suggests that Rab GTPases are crucial components of the myosin organelle receptor machinery. Better understood is the case of the melanosome where Rab27a recruits a specific effector called melanophilin, which in turn binds myosin Va. The presence of a linker protein between a Rab and a myosin may represent a general mechanism. We argue that Rabs are ideally suited to perform this role as they are exquisite organelle markers. Furthermore, the molecular switch property of Rabs may enable them to regulate the timing of the myosin association with the target organelle.
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Cites
The Rab5 effector EEA1 is a core component of endosome docking
Christoforidis, S., McBride, H. M., Burgoyne, R. D., & Zerial, M. (1999) · Nature · doi:10.1038/17618 · Cited by 854
Keratinocyte-Melanocyte Interactions During Melanosome Transfer
Seiberg, M. (2001) · Pigment Cell Research · doi:10.1034/j.1600-0749.2001.140402.x · Cited by 290
Bahadoran, P., Aberdam, E., Mantoux, F., Buscà, R., Bille, K., Yalman, N., de Saint-Basile, G., Casaroli-Marano, R., Ortonne, J.-P., & Ballotti, R. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.843 · Cited by 221
Futter, C. E., Ramalho, J. S., Jaissle, G. B., Seeliger, M. W., & Seabra, M. C. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-10-0772 · Cited by 110
Self-citation
Cited by
Rab GTPases as coordinators of vesicle traffic
Stenmark, H. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2728 · Cited by 3,413
Rab27a and Rab27b control different steps of the exosome secretion pathway
Ostrowski, M., Carmo, N. B., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,750
Self-citationMitochondria: More Than Just a Powerhouse
McBride, H. M., Neuspiel, M., & Wasiak, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.054 · Cited by 1,985
Axonal transport and neurodegenerative disease
Chevalier-Larsen, E., & Holzbaur, E. L. F. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.04.002 · Cited by 438
Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis
Sahlender, D. A., Roberts, R. C., Arden, S. D., Spudich, G., Taylor, M. J., Luzio, J. P., Kendrick-Jones, J., & Buss, F. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200501162 · Cited by 426
Metadata
- Authors
- Seabra, M. C., & Coudrier, E.
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2004-04-15
- Volume
- 5
- Issue
- 6
- Pages
- 393-399
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W1655601628
- Cited by
- 199
- References
- 4
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- closed
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