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Cited by 450

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Update on the evaluation of hypersensitivity reactions to betalactams

Open access
Blanca, M., Romano, A., Torres, M. J., Férnandez, J., Mayorga, C., Rodriguez, J., Demoly, P., Bousquet, P. J., Merk, H. F., Sanz, M. L., Ott, H., Atanasković-Marković, M.·2009·Allergy

Abstract

Hypersensitivity reactions to betalactams (BLs) are classified as immediate or nonimmediate. The former usually appear within 1 h of drug-intake and are mediated by specific IgE-antibodies. Nonimmediate reactions are those occurring more than 1 h after drug-intake, and they can be T-cell mediated. The diagnostic evaluation of allergic reactions to BLs has changed over the last 5 years, for several reasons. Major and minor determinants are no longer commercially available for skin testing in many countries. In immediate allergic reactions, the sensitivity of skin testing and immunoassays is decreasing and new in vitro methods, such as the basophil activation test, are gaining importance for diagnosis. For nonimmediate reactions, skin testing appears to be less sensitive than previous results, although more studies need to be carried out in this direction. Nevertheless, the drug provocation test is still necessary for diagnosis.

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Metadata

Authors
Blanca, M., Romano, A., Torres, M. J., Férnandez, J., Mayorga, C., Rodriguez, J., Demoly, P., Bousquet, P. J., Merk, H. F., Sanz, M. L., Ott, H., & Atanasković-Marković, M.
Venue
Allergy
Publisher
Wiley
Published
2009-01
Volume
64
Issue
2
Pages
183-193
ISSN
  • 0105-4538 (ISSN-L)
  • 1398-9995
OpenAlex
W4243807236
Cited by
450
References
1
FWCI
17.72
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Update on the evaluation of hypersensitivity reactions to betalactams. https://app.cochat.ai/papers/10.1111/j.1398-9995.2008.01916.x
The paper
Blanca, M., Romano, A., Torres, M. J., Férnandez, J., Mayorga, C., Rodriguez, J., Demoly, P., Bousquet, P. J., Merk, H. F., Sanz, M. L., Ott, H., & Atanasković-Marković, M. (2009). Update on the evaluation of hypersensitivity reactions to betalactams. Allergy. https://doi.org/10.1111/j.1398-9995.2008.01916.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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