The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids
Open accessAbstract
Background: Esophageal remodeling occurs in eosinophilic esophagitis (EE) patients but whether the components of remodeling in the subepithelium are reversible by administration of topical oral corticosteroids is unknown. Methods: We quantitated the degree of lamina propria remodeling in esophageal biopsies obtained before and after at least 3 months of therapy with budesonide in 16 pediatric EE subjects. In addition, we investigated whether corticosteroid therapy modulated vascular activation (expression of VCAM‐1; level of interstitial edema), TGFβ 1 activation (levels of TGFβ 1, phosphorylated Smad2/3), and performed a pilot analysis of a polymorphism in the TGFβ 1 promoter in relation to EE subjects who had reduced remodeling with budesonide therapy. Results: EE subjects were stratified based on the presence (n = 9) or absence (n = 7) of decreased epithelial eosinophilia following budesonide. Patients with residual eosinophil counts of ≤7 eosinophils per high power field in the epithelial space (responders) demonstrated significantly reduced esophageal remodeling with decreased fibrosis, TGFβ 1 and pSmad2/3 positive cells, and decreased vascular activation in association with budesonide therapy. Responders were more likely to have a CC genotype at the −509 position in the TGFβ 1 promoter. Conclusions: Reductions in epithelial eosinophils following budesonide therapy were associated with significantly reduced esophageal remodeling.
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Furuta, G. T., Liacouras, C. A., Collins, M. H., Gupta, S. K., Justinich, C., Putnam, P. E., Bonis, P., Hassall, E., Straumann, A., & Rothenberg, M. E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.017 · Cited by 1,673
Straumann, A., Spichtin, H.-P., Grize, L., Bucher, K. A., Beglinger, C., & Simon, H.-U. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.09.024 · Cited by 710
Konikoff, M. R., Noel, R. J., Blanchard, C., Kirby, C., Jameson, S. C., Buckmeier, B. K., Akers, R., Cohen, M. B., Collins, M. H., Assa’ad, A. H., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.033 · Cited by 585
Self-citationEsophageal remodeling in pediatric eosinophilic esophagitis
Aceves, S. S., Newbury, R. O., Dohil, R., Bastian, J. F., & Broide, D. H. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.10.016 · Cited by 432
Self-citationSchaefer, E. T., Fitzgerald, J. F., Molleston, J. P., Croffie, J. M. B., Pfefferkorn, M. D., Corkins, M. R., Lim, J. D., Steiner, S. J., & Gupta, S. K. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.11.008 · Cited by 413
Eosinophilic Esophagitis: A Prevalent Disease in the United States That Affects All Age Groups
Kapel, R. C., Miller, J. K., Torres, C., Aksoy, S., Lash, R., & Katzka, D. A. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.016 · Cited by 341
Esophageal Remodeling Develops as a Consequence of Tissue Specific IL-5-Induced Eosinophilia
Mishra, A., Wang, M., Pemmaraju, V. R., Collins, M. H., Fulkerson, P. C., Abonia, J. P., Blanchard, C., Putnam, P. E., & Rothenberg, M. E. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.10.002 · Cited by 255
Oral Viscous Budesonide: A Potential New Therapy for Eosinophilic Esophagitis in Children
Aceves, S. S., Bastian, J. F., Newbury, R. O., & Dohil, R. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01379.x · Cited by 245
Self-citationImmunologic and inflammatory mechanisms that drive asthma progression to remodeling
Broide, D. H. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.01.031 · Cited by 244
Self-citationTransforming Growth Factor-β 1 Promoter Polymorphism C–509T Is Associated with Asthma
Silverman, E. S., Palmer, L. J., Subramaniam, V., Hallock, A., Mathew, S., Vallone, J., Faffe, D. S., Shikanai, T., Raby, B. A., Weiss, S. T., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200307-973oc · Cited by 244
Cited by
Eosinophilic esophagitis: Updated consensus recommendations for children and adults
Liacouras, C. A., Furuta, G. T., Hirano, I., Atkins, D., Attwood, S. E., Bonis, P. A., Burks, A. W., Chehade, M., Collins, M. H., Dellon, E. S., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.02.040 · Cited by 2,073
Self-citationHigh prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders
Abonia, J. P., Wen, T., Stucke, E. M., Grotjan, T., Griffith, M. S., Kemme, K. A., Collins, M. H., Putnam, P. E., Franciosi, J. P., von Tiehl, K. F., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.030 · Cited by 195
Metadata
- Authors
- Aceves, S. S., Newbury, R. O., Chen, D., Mueller, J., Dohil, R., Hoffman, H., Bastian, J. F., & Broide, D. H.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2009-12-11
- Volume
- 65
- Issue
- 1
- Pages
- 109-116
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W1603709335
- Cited by
- 297
- References
- 15
- FWCI
- 18.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Aceves, S. S., Newbury, R. O., Chen, D., Mueller, J., Dohil, R., Hoffman, H., Bastian, J. F., & Broide, D. H. (2010). Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids. Allergy. https://doi.org/10.1111/j.1398-9995.2009.02142.x
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