The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Oral Viscous Budesonide: A Potential New Therapy for Eosinophilic Esophagitis in Children
Abstract
BACKGROUND: Eosinophilic esophagitis (EE) is a disorder characterized typically by pan-esophageal eosinophilia. We evaluate a palatable, long-acting topical corticosteroid preparation for the treatment of EE. STUDY DESIGN: This is a retrospective analysis of symptoms, endoscopic and histologic findings, efficacy, and safety of treatment in children with EE receiving oral viscous budesonide. Response to therapy was determined histologically by the number of eos/hpf. Patients were classified by histology into responders (0-7 eos/hpf), partial responders (8-23 eos/hpf), and nonresponders (>/=24 eos/hpf). A symptom score (max. 14) and an EE endoscopy score (max. 8) were used to compare data. RESULTS: In 20 children (mean age 5.5 yr, median age 4.1 yr) the mean highest eosinophil count was 87 eos/hpf (range 30-170) before and 7 eos/hpf (range 0-50, P < 0.0001) after therapy. There were 16 (80%) responders, 1 partial responder, and 3 nonresponders. Commonest pretreatment symptoms were nausea, vomiting, pain, and heartburn. The mean symptom score fell from 4.4 to 0.8 (P < 0.0001) and the mean endoscopy score from 3.6 to 0.8 (P < 0.0001). No significant adverse events were reported. Morning cortisol levels were within normal limits. CONCLUSIONS: Topical viscous budesonide is a safe and effective therapy for EE in young children.
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Cites
Remedios, M., Campbell, C., Jones, D. M., & Kerlin, P. (2006) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2005.07.049 · Cited by 373
Pollen and eosinophilic esophagitis
Fogg, M. I., Ruchelli, E., & Spergel, J. M. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(03)01715-9 · Cited by 301
Cited by
Furuta, G. T., Liacouras, C. A., Collins, M. H., Gupta, S. K., Justinich, C., Putnam, P. E., Bonis, P., Hassall, E., Straumann, A., & Rothenberg, M. E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.017 · Cited by 1,673
Dellon, E. S., Gonsalves, N., Hirano, I., Furuta, G. T., Liacouras, C. A., & Katzka, D. A. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.71 · Cited by 1,159
14 Years of Eosinophilic Esophagitis: Clinical Features and Prognosis
Spergel, J. M., Brown‐Whitehorn, T. F., Beausoleil, J. L., Franciosi, J., Shuker, M., Verma, R., & Liacouras, C. A. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181788282 · Cited by 467
Aceves, S. S., Newbury, R. O., Chen, D., Mueller, J., Dohil, R., Hoffman, H., Bastian, J. F., & Broide, D. H. (2010) · Allergy · doi:10.1111/j.1398-9995.2009.02142.x · Cited by 297
Self-citationComparative dietary therapy effectiveness in remission of pediatric eosinophilic esophagitis
Henderson, C. J., Abonia, J. P., King, E. C., Putnam, P. E., Collins, M. H., Franciosi, J. P., & Rothenberg, M. E. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.03.023 · Cited by 275
Metadata
- Authors
- Aceves, S. S., Bastian, J. F., Newbury, R. O., & Dohil, R.
- Venue
- The American Journal of Gastroenterology
- Published
- 2007-10
- Volume
- 102
- Issue
- 10
- Pages
- 2271-2279
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2005052157
- Cited by
- 245
- References
- 2
- FWCI
- 15.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Aceves, S. S., Bastian, J. F., Newbury, R. O., & Dohil, R. (2007). Oral Viscous Budesonide: A Potential New Therapy for Eosinophilic Esophagitis in Children. The American Journal of Gastroenterology. https://doi.org/10.1111/j.1572-0241.2007.01379.x
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