Infant eczema, infant sleeping problems, and mental health at 10 years of age: the prospective birth cohort study LISAplus: Infant eczema, sleep problems & mental health at age 10
Abstract
Background Cross-sectional studies suggest an association between eczema and mental health problems, possibly modified by sleeping problems, but prospective evidence is missing. We aimed to prospectively investigate the relationship between infant eczema (within first 2 years of age), infant sleeping problems (within first 2 years of age), and the risk of mental health problems at 10 years of age. Methods Between 1997 and 1999, a population-based birth cohort was recruited in Munich, Leipzig, Wesel, and Bad Honnef, Germany, and followed until 10 years of age. Physician-diagnosed eczema, parent-reported sleeping problems, and known environmental risk factors for atopy were regularly assessed until 10 years of age. Mental health was measured using the Strengths and Difficulties Questionnaire (parent version) at 10 years of age. We applied logistic regression modeling adjusting for environmental and lifestyle factors, allergic comorbidity, and family history of eczema. Results From the original cohort of 3097 neonates, 1658 (54%) were followed until age 10, while 1578 (51%) were eligible for analysis. In the fully adjusted model, children with infant eczema were at increased risk of hyperactivity/inattention at 10 years of age [odds ratio (OR) 1.78; 95% confidence interval (95% CI) 1.02-3.09]. Infant eczema with concurrent sleeping problems predicted emotional problems [OR 2.63; 95% confidence interval (95% CI) 1.20-5.76] and conduct problems (OR 3.03; 95% CI 1.01-9.12) at 10 ye…
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A longitudinal study that followed 1,578 children until age 10 showed that AD in childhood and sleep problems are significant predictors of conduct and emotional disorders at age 10.
“A longitudinal study that followed 1,578 children until age 10 showed that AD in childhood and sleep problems are significant predictors of conduct and emotional disorders at age 10.115”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [115]
Cites
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What are the best outcome measurements for atopic eczema? A systematic review
Schmitt, J., Langan, S., & Williams, H. C. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.08.011 · Cited by 388 · cited 1× · see citing works
“Another important limitation of our study is the lack of data on the severity of eczema based on a validated measurement (32) and the use of a validated instrument to repeatedly measure sleeping problems of all participants at each follow-up.”
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Developmental comorbidity in attention-deficit/hyperactivity disorder
Taurines, R., Schmitt, J., Renner, T., Conner, A. C., Warnke, A., & Romanos, M. (2010) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-010-0040-0 · Cited by 198 · see citing works
Self-citationKern, C., Wan, J., LeWinn, K. Z., Ramirez, F. D., Lee, Y., McCulloch, C. E., Langan, S. M., & Abuabara, K. (2021) · JAMA Dermatology · doi:10.1001/jamadermatol.2021.2657 · Cited by 103 · see citing works
Update on the pathogenesis of atopic dermatitis.
Criado, P. R., Miot, H. A., Bueno-Filho, R., Ianhez, M., Criado, R. F. J., & de Castro, C. C. S. (2024) · Anais brasileiros de dermatologia · doi:10.1016/j.abd.2024.06.001 · Cited by 66 · see citing works
- Authors
- Schmitt, J., Chen, C.-M., Apfelbacher, C., Romanos, M., Lehmann, I., Herbarth, O., Schaaf, B., Kraemer, U., von Berg, A., Wichmann, H.-E., Heinrich, J., & the LISA-plus Study Group
- Affiliations
- University Hospital Carl Gustav Carus (DE)
- Helmholtz Munich (DE)
- University Hospital Heidelberg (DE)
- Universitätsklinikum Würzburg (DE)
- Helmholtz Centre for Environmental Research (DE)
- Leipzig University (DE)
- Leibniz Institute of Environmental Medicine (DE)
- Corresponding author
- Schmitt, J.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2010-09-29
- Volume
- 66
- Issue
- 3
- Pages
- 404-411
- ISSN
- 0105-4538 (ISSN-L)
- OpenAlex
- W1570652939
- Cited by
- 131
- References
- 3
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 10 · 2020: 4 · 2019: 16 · 2018: 10 · 2017: 7 · 2016: 12 · 2015: 14 · 2014: 3 · 2013: 6 · 2012: 14
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Allergy (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- infantile eczema, mental health, hyperactivity/inattention, emotional problems, conduct problems, atopy, Strengths and Difficulties Questionnaire, child behavior problems, allergic comorbidities
- MeSH terms
- Mental Disorders, Child, Child, Preschool, Dermatitis, Atopic, Female, Germany, Humans, Infant, Infant, Newborn, Male, Prospective Studies, Surveys and Questionnaires, Risk Factors, Sleep Wake Disorders, Cohort Studies
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