Dermatological manifestations of 71 Down syndrome children admitted to a clinical genetics unit
Abstract
Seventy‐one children with Down syndrome who were admitted consecutively to Hacettepe University Children's Hospital Genetics Department were examined for skin disorders. None of the patients suffered directly from skin disorders. All were living with their families and had approximately similar living conditions. There were 29 children with palmoplantar hyperkeratosis (40.8%), seven with xerosis (9.8%), 22 with seborrheic dermatitis (30.9%), 14 with fissured tongue (20%), eight with geographic tongue (11.2%), and nine with cutis marmorata (12.6%). Nine had normal skin findings. Since palmoplantar hyperkeratosis may be a result of vitamin A deficiency, the serum vitamin A levels of these patients were evaluated. There was no statistical difference between vitamin A levels of the children with Down syndrome and the control group.
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Familial amyloidotic polyneuropathy and Down syndrome have also been associated with SD.
“Other medical conditions, such as familial amyloidotic polyneuropathy and Down syndrome, have also been associated with SD [95,96].”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [95]
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Seborrheic Dermatitis and Dandruff: A Comprehensive Review
(2015) · Journal of Clinical and Investigative Dermatology · doi:10.13188/2373-1044.1000019 · Cited by 398 · see citing works
Naldi, L., & Rebora, A. (2009) · New England Journal of Medicine · doi:10.1056/nejmcp0806464 · Cited by 188 · see citing works
- Authors
- Erics, M., Balci, S., & Atakan, N.
- Affiliations
- Hacettepe University (TR)
- Corresponding author
- Erics, M.
- ORCID
- Atakan, Nilgün
- Venue
- Clinical Genetics
- Publisher
- Wiley
- Published
- 1996-11
- Volume
- 50
- Issue
- 5
- Pages
- 317-320
- ISSN
- 0009-9163 (ISSN-L)
- 1399-0004
- OpenAlex
- W1985688180
- Cited by
- 80
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 4 · 2013: 4 · 2012: 1
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Dermatoglyphics and Human Traits
- Keywords
- Down syndrome, cutaneous manifestations, skin diseases, palmoplantar keratoderma, dry skin, seborrheic dermatitis, fissured tongue, geographic tongue, cutis marmorata, vitamin A deficiency, serum vitamin A, children
- MeSH terms
- Child, Child, Preschool, Chromosomes, Down Syndrome, Female, Humans, Infant, Male, Prospective Studies, Skin Diseases, Vitamin A
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