The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Mannose‐binding lectin in innate immunity: past, present and future
Open accessAbstract
The human collectin, mannose‐binding lectin (MBL), is an important protein of the humoral innate immune system. With multiple carbohydrate‐recognition domains, it is able to bind to sugar groups displayed on the surfaces of a wide range of microorganisms and thereby provide first‐line defence. Importantly, it also activates the complement system through a distinctive third pathway, independent of both antibody and the C1 complex. Three single point mutations in exon 1 of the expressed human MBL‐2 gene appear to impair the generation of functional oligomers. Such deficiencies of functional protein are common in certain populations, e.g. in sub‐Saharan Africa, but virtually absent in others, e.g. indigenous Australians. MBL disease association studies have been a fruitful area of research and implicate a role for MBL in infective, inflammatory and autoimmune disease processes. Overall, there appears to be a genetic balance in which individuals generally benefit from high levels of the protein. However, in certain situations, reduced levels of circulating MBL may be beneficial to the host and this may explain the persistence of the deleterious gene polymorphisms in many population groups.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
Rota, P. A., Oberste, M. S., Monroe, S. S., Nix, W. A., Campagnoli, R., Icenogle, J. P., Peñaranda, S., Bankamp, B., Maher, K., Chen, M.-H., et al. (2003) · Science · doi:10.1126/science.1085952 · Cited by 2,474
The Genome Sequence of the SARS-Associated Coronavirus
Marra, M. A., Jones, S. J. M., Astell, C. R., Holt, R. A., Brooks-Wilson, A., Butterfield, Y. S. N., Khattra, J., Asano, J. K., Barber, S. A., Chan, S. Y., et al. (2003) · Science · doi:10.1126/science.1085953 · Cited by 2,026
Protection Afforded by Sickle-cell Trait Against Subtertian Malarial Infection
Allison, A. C. (1954) · BMJ · doi:10.1136/bmj.1.4857.290 · Cited by 1,291
Two distinct classes of carbohydrate-recognition domains in animal lectins.
Drickamer, K. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81549-1 · Cited by 1,262
Ogden, C. A., deCathelineau, A., Hoffmann, P. R., Bratton, D., Ghebrehiwet, B., Fadok, V. A., & Henson, P. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.781 · Cited by 1,147
Structure of a C-type mannose-binding protein complexed with an oligosaccharide
Weis, W. I., Drickamer, K., & Hendrickson, W. A. (1992) · Nature · doi:10.1038/360127a0 · Cited by 885
A second serine protease associated with mannan-binding lectin that activates complement
Thiel, S., Vorup-Jensen, T., Stover, C. M., Schwaeble, W., Laursen, S. B., Poulsen, K., Willis, A. C., Eggleton, P., Hansen, S., Holmskov, U., et al. (1997) · Nature · doi:10.1038/386506a0 · Cited by 808
Malhotra, R., Wormald, M. R., Rudd, P. M., Fischer, P. B., Dwek, R. A., & Sim, R. B. (1995) · Nature Medicine · doi:10.1038/nm0395-237 · Cited by 786
Collectins and Ficolins: Humoral Lectins of the Innate Immune Defense
Holmskov, U., Thiel, S., & Jensenius, J. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140954 · Cited by 762
Madsen, H. O., Garred, P., Thiel, S., Kurtzhals, J. A., Lamm, L. U., Ryder, L. P., & Svejgaard, A. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.6.3013 · Cited by 758
Cited by
Hepatocytes: a key cell type for innate immunity
Zhou, Z., Xu, M.-J., & Gao, B. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.97 · Cited by 472
Mannose‐binding lectin and innate immunity
Eddie Ip, W. K., Takahashi, K., Alan Ezekowitz, R., & Stuart, L. M. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00789.x · Cited by 422
van Wijck, K., Lenaerts, K., Grootjans, J., Wijnands, K. A. P., Poeze, M., van Loon, L. J. C., Dejong, C. H. C., & Buurman, W. A. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00066.2012 · Cited by 285
Bitter-sweet symphony: glycan–lectin interactions in virus biology
Van Breedam, W., Pöhlmann, S., Favoreel, H. W., de Groot, R. J., & Nauwynck, H. J. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12052 · Cited by 141
Radu, R. A., Hu, J., Jiang, Z., & Bok, D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.548669 · Cited by 44
Metadata
- Authors
- Dommett, R. M., Klein, N., & Turner, M. W.
- Venue
- Tissue Antigens
- Publisher
- Wiley
- Published
- 2006-09
- Volume
- 68
- Issue
- 3
- Pages
- 193-209
- ISSN
- 0001-2815 (ISSN-L)
- 1399-0039
- OpenAlex
- W2105614022
- Cited by
- 342
- References
- 102
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mannose‐binding lectin in innate immunity: past, present and future. https://app.cochat.ai/papers/10.1111/j.1399-0039.2006.00649.x
- The paper
- Dommett, R. M., Klein, N., & Turner, M. W. (2006). Mannose‐binding lectin in innate immunity: past, present and future. Tissue Antigens. https://doi.org/10.1111/j.1399-0039.2006.00649.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
