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Cited by 2,026

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The Genome Sequence of the SARS-Associated Coronavirus

Marra, Marco A., Jones, Steven J. M., Astell, Caroline R., Holt, Robert A., Brooks-Wilson, Angela, Butterfield, Yaron S. N., Khattra, Jaswinder, Asano, Jennifer K., Barber, Sarah A., Chan, Susanna Y., Cloutier, Alison, Coughlin, Shaun M., Freeman, Doug, Girn, Noreen, Griffith, Obi L., Leach, Stephen R., Mayo, Michael, McDonald, Helen, Montgomery, Stephen B., Pandoh, Pawan K., Petrescu, Anca S., Robertson, A. Gordon, Schein, Jacqueline E., Siddiqui, Asim, Smailus, Duane E., Stott, Jeff M., Yang, George S., Plummer, Francis, Andonov, Anton, Artsob, Harvey, Bastien, Nathalie, Bernard, Kathy, Booth, Timothy F., Bowness, Donnie, Czub, Martin, Drebot, Michael, Fernando, Lisa, Flick, Ramon, Garbutt, Michael, Gray, Michael, Grolla, Allen, Jones, Steven, Feldmann, Heinz, Meyers, Adrienne, Kabani, Amin, Li, Yan, Normand, Susan, Stroher, Ute, Tipples, Graham A., Tyler, Shaun, Vogrig, Robert, Ward, Diane, Watson, Brynn, Brunham, Robert C., Krajden, Mel, Petric, Martin, Skowronski, Danuta M., Upton, Chris, Roper, Rachel L.·2003·Science
DOI 10.1126/science.1085953
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Abstract

We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)–associated coronavirus known as the Tor2 isolate. The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. The genome sequence will aid in the diagnosis of SARS virus infection in humans and potential animal hosts (using polymerase chain reaction and immunological tests), in the development of antivirals (including neutralizing antibodies), and in the identification of putative epitopes for vaccine development.

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Metadata

Authors
Marra, M. A., Jones, S. J. M., Astell, C. R., Holt, R. A., Brooks-Wilson, A., Butterfield, Y. S. N., Khattra, J., Asano, J. K., Barber, S. A., Chan, S. Y., Cloutier, A., Coughlin, S. M., Freeman, D., Girn, N., Griffith, O. L., Leach, S. R., Mayo, M., McDonald, H., Montgomery, S. B., Pandoh, P. K., Petrescu, A. S., Robertson, A. G., Schein, J. E., Siddiqui, A., Smailus, D. E., Stott, J. M., Yang, G. S., Plummer, F., Andonov, A., Artsob, H., Bastien, N., Bernard, K., Booth, T. F., Bowness, D., Czub, M., Drebot, M., Fernando, L., Flick, R., Garbutt, M., Gray, M., Grolla, A., Jones, S., Feldmann, H., Meyers, A., Kabani, A., Li, Y., Normand, S., Stroher, U., Tipples, G. A., Tyler, S., Vogrig, R., Ward, D., Watson, B., Brunham, R. C., Krajden, M., Petric, M., Skowronski, D. M., Upton, C., & Roper, R. L.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2003-05-30
Volume
300
Issue
5624
Pages
1399-1404
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1085953
OpenAlex
W2169198329
Cited by
2,026
References
1
FWCI
175.73
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Genome Sequence of the SARS-Associated Coronavirus. https://app.cochat.ai/papers/10.1126/science.1085953
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Marra, M. A., Jones, S. J. M., Astell, C. R., Holt, R. A., Brooks-Wilson, A., Butterfield, Y. S. N., Khattra, J., Asano, J. K., Barber, S. A., Chan, S. Y., Cloutier, A., Coughlin, S. M., Freeman, D., Girn, N., Griffith, O. L., Leach, S. R., Mayo, M., McDonald, H., Montgomery, S. B., . . . Roper, R. L. (2003). The Genome Sequence of the SARS-Associated Coronavirus. Science. https://doi.org/10.1126/science.1085953

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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