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Solid‐phase peptide synthesis: a silver anniversary report*
Abstract
It has been a quarter of a century since Merrifield's initial report on solid‐phase peptide synthesis. The field has matured significantly in recent years with a better understanding of the underlying chemistry. This is reflected by new, milder orthogonal protection schemes and more efficient coupling methods, some of which have been incorporated into automated systems. Advances in purification, especially high performance liquid chromatography, have had a major impact. The efficacy of these improvements has been demonstrated by an impressive litany of applications to biological problems.
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Citations
Cited by
Seebach, D. (1990) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199013201 · Cited by 577
Kinetics of Molecular Chaperone Action
Schmid, D., Baici, A., Gehring, H., & Christen, P. (1994) · Science · doi:10.1126/science.8310296 · Cited by 438
A Chemical Approach to Protein Design—Template‐Assembled Synthetic Proteins (TASP)
Mutter, M., & Vuilleumier, S. (1989) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198905353 · Cited by 400
Jensen, K. J., Alsina, J., Songster, M. F., Vágner, J., Albericio, F., & Barany, G. (1998) · Journal of the American Chemical Society · doi:10.1021/ja974116f · Cited by 277
Self-citationUse of Onium Salt-Based Coupling Reagents in Peptide Synthesis1
Albericio, F., Bofill, J. M., El-Faham, A., & Kates, S. A. (1998) · The Journal of Organic Chemistry · doi:10.1021/jo980807y · Cited by 276
Metadata
- Authors
- BARANY, G., KNEIB‐CORDONIER, N., & MULLEN, D. G.
- Venue
- International Journal of Peptide and Protein Research
- Publisher
- Wiley
- Published
- 1987-12
- Volume
- 30
- Issue
- 6
- Pages
- 705-739
- ISSN
- 0367-8377 (ISSN-L)
- OpenAlex
- W2062535360
- Cited by
- 182
- References
- 0
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Solid‐phase peptide synthesis: a silver anniversary report*. https://app.cochat.ai/papers/10.1111/j.1399-3011.1987.tb03385.x
- The paper
- BARANY, G., KNEIB‐CORDONIER, N., & MULLEN, D. G. (1987). Solid‐phase peptide synthesis: a silver anniversary report*. International Journal of Peptide and Protein Research. https://doi.org/10.1111/j.1399-3011.1987.tb03385.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
