The DOI matches its Crossref record; 21 of the 23 references it cites were found in a registry or an index.
Progressive deterioration of β-cell function in obese youth with type 2 diabetes: β-Cell function in youth T2DM
Open accessAbstract
OBJECTIVE: In adults, type 2 diabetes (T2DM) is characterized with progressive deterioration in insulin secretion. Data are scanty in youth. We investigated prospectively the change in β-cell function and in insulin sensitivity in youth with T2DM. RESEARCH DESIGN AND METHODS: Six adolescents with T2DM [hemoglobin A1c (HbA1c) 6.6 ± 1.0%] underwent evaluation of hepatic glucose production (HGP; [6,6-²H₂] glucose), insulin-stimulated glucose disposal (Rd; hyperinsulinemic-euglycemic clamp), first- and second-phase insulin/C-peptide secretion (hyperglycemic clamp), body composition dual energy X-ray absorptiometry (DEXA), and abdominal adiposity (computed tomography) within 3 yr of the diagnosis of diabetes and after 12-16 months of follow-up. RESULTS: Weight, body mass index (37.1 ± 6.9), HbA1c (6.3 ± 0.7%), HGP (2.8 ± 1.2 mg/kg/min), and Rd (4.9 ± 3.4 mg/kg/min) did not change significantly from baseline. However, first-phase insulin and C-peptide declined (152.6 ± 261.2 vs. 75.9 ± 108.5 μU/mL, p = 0.028; 8.0 ± 6.3 vs. 5.9 ± 4.4 ng/mL, p = 0.048, respectively) with no significant change in second-phase insulin/C-peptide. The rate of decline in β-cell function was ∼20% per year. CONCLUSIONS: After a median duration of 20 months of diabetes, youth with T2DM manifest a rapid decline in β-cell function with no significant changes in peripheral or hepatic insulin sensitivity. Interventions to retard this deterioration in β-cell function should be investigated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“and younger people with T2DM can have much higher (up to 3 times) amounts of liver fat compared with BMI-matched non-diabetic controls and compared with presentations of T2DM in middle and later life 24,”
From Type 2 diabetes in adolescents and young adults (2018) · cites this paper as [24]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
10-year follow-up of intensive glucose control in type 2 diabetes
Holman, R. R., Paul, S. K., Bethel, M. A., Matthews, D. R., & Neil, H. A. W. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0806470 · Cited by 7,751
The Importance of -Cell Failure in the Development and Progression of Type 2 Diabetes
Kahn, S. E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7713 · Cited by 710
Prevalence of Diabetes Complications in Adolescents With Type 2 Compared With Type 1 Diabetes
Eppens, M. C., Craig, M. E., Cusumano, J. M., Hing, S. J., Chan, A. K. F., Howard, N. J., Silink, M., & Donaghue, K. C. (2006) · Diabetes Care · doi:10.2337/dc05-2470 · Cited by 468
Acute and chronic complications of type 2 diabetes mellitus in children and adolescents
Pinhas‐Hamiel, O., & Zeitler, P. S. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60821-6 · Cited by 386
Bacha, F. F., Saad, R. J., Gungor, N., & Arslanian, S. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.2.547 · Cited by 278
Self-citationThe TODAY Study Group (2007) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00237.x · Cited by 260
Kahn, S. E., Lachin, J. M., Zinman, B., Haffner, S. M., Aftring, R. P., Paul, G., Kravitz, B. G., Herman, W. H., Viberti, G., Holman, R. R., et al. (2011) · Diabetes · doi:10.2337/db10-1392 · Cited by 249
Gungor, N., Bacha, F., Saad, R., Janosky, J., & Arslanian, S. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.638 · Cited by 186
Self-citationBorg, H., Gottsäter, A., Fernlund, P., & Sundkvist, G. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1754 · Cited by 168
Characterization of insulin secretion and resistance in type 2 diabetes of adolescents
Druet, C., Tubiana-Rufi, N., Chevenne, D., Rigal, O., Polak, M., & Levy-Marchal, C. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1672 · Cited by 93
Flagged first, then by citations
2 of the 23 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–106 of 106
Diabetes in Children and Adolescents
Šumnı́k, Z., & Průhová, Š. (2023) · Endocrinology · doi:10.1007/978-3-030-18901-3_10-1
Bacha, F. F. (2024) · Diabetes Care · doi:10.2337/dci24-0006
Self-citationHao, S., Westbrook, A. L., Sinha, C. B., Hsia, D. S., & Vellanki, P. (2025) · Endocrine Practice · doi:10.1016/j.eprac.2025.10.001
Glucose metabolism disorders in children and adolescents with obesity
Veselá, L., Šumnı́k, Z., & Hainerová, I. A. (2026) · Česko-slovenská pediatrie · doi:10.55095/cspediatrie2026/019
McNeel, K., Bhanji, Z., Le, V., Lee, J., & Gallicano, I. (2026) · Considerations in Medicine · doi:10.1136/conmed-2026-000096
Wang, J., & Wei, C. (2026) · Journal of the National Medical Association · doi:10.1016/j.jnma.2026.101112
Metadata
- Authors
- Bacha, F., Gungor, N., Lee, S., & Arslanian, S. A.
- Affiliations
- University of Pittsburgh (US)
- Louisiana State University Health Sciences Center Shreveport (US)
- Corresponding author
- Bacha, Fida
- Venue
- Pediatric Diabetes
- Publisher
- Hindawi Limited
- Published
- 2012-08-23
- Volume
- 14
- Issue
- 2
- Pages
- 106-111
- ISSN
- 1399-543X (ISSN-L)
- PMC
- PMC3648791
- OpenAlex
- W1598677707
- Cited by
- 106
- References
- 23
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 12 · 2023: 8 · 2022: 12 · 2021: 11 · 2020: 9 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pediatric Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Defense (UL1 RR024153, K24 HD01357, MO1 RR00084, UL1TR000005)
- Deutsches Krebsforschungszentrum
- National Institutes of Health (UL1TR000005)
- U.S. Public Health Service (UL1TR000005, K24 HD01357, UL1 RR024153)
- National Center for Research Resources (MO-1-RR-00084, UL1RR024153, M01RR000084)
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K24HD001357)
- Children's Hospital of Pittsburgh
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- type 2 diabetes, adolescents, beta-cell function, insulin secretion, first-phase insulin secretion, C-peptide, insulin sensitivity, hepatic glucose production, insulin-stimulated glucose disposal, obesity, disease progression, abdominal fat
- MeSH terms
- Adolescent, Blood Glucose, Body Composition, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Insulin Resistance, Male, Glucose Clamp Technique, Absorptiometry, Photon, Body Mass Index, Insulin-Secreting Cells, Obesity, Abdominal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
