Cited by 106Pancreatic function and diabetesDiabetes Treatment and ManagementDiabetes and associated disorders

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Progressive deterioration of β-cell function in obese youth with type 2 diabetes: β-Cell function in youth T2DM

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Bacha, Fida, Gungor, Neslihan, Lee, SoJung, Arslanian, Silva A·2013·Pediatric Diabetes

DOI 10.1111/j.1399-5448.2012.00915.xPMC PMC3648791

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Abstract

OBJECTIVE: In adults, type 2 diabetes (T2DM) is characterized with progressive deterioration in insulin secretion. Data are scanty in youth. We investigated prospectively the change in β-cell function and in insulin sensitivity in youth with T2DM. RESEARCH DESIGN AND METHODS: Six adolescents with T2DM [hemoglobin A1c (HbA1c) 6.6 ± 1.0%] underwent evaluation of hepatic glucose production (HGP; [6,6-²H₂] glucose), insulin-stimulated glucose disposal (Rd; hyperinsulinemic-euglycemic clamp), first- and second-phase insulin/C-peptide secretion (hyperglycemic clamp), body composition dual energy X-ray absorptiometry (DEXA), and abdominal adiposity (computed tomography) within 3 yr of the diagnosis of diabetes and after 12-16 months of follow-up. RESULTS: Weight, body mass index (37.1 ± 6.9), HbA1c (6.3 ± 0.7%), HGP (2.8 ± 1.2 mg/kg/min), and Rd (4.9 ± 3.4 mg/kg/min) did not change significantly from baseline. However, first-phase insulin and C-peptide declined (152.6 ± 261.2 vs. 75.9 ± 108.5 μU/mL, p = 0.028; 8.0 ± 6.3 vs. 5.9 ± 4.4 ng/mL, p = 0.048, respectively) with no significant change in second-phase insulin/C-peptide. The rate of decline in β-cell function was ∼20% per year. CONCLUSIONS: After a median duration of 20 months of diabetes, youth with T2DM manifest a rapid decline in β-cell function with no significant changes in peripheral or hepatic insulin sensitivity. Interventions to retard this deterioration in β-cell function should be investigated.

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Authors: Bacha, F., Gungor, N., Lee, S., & Arslanian, S. A.
Affiliations: University of Pittsburgh (US)
Louisiana State University Health Sciences Center Shreveport (US)
Corresponding author: Bacha, Fida
ORCID: Bacha, Fida
Lee, SoJung
Arslanian, Silva A
Venue: Pediatric Diabetes
Publisher: Hindawi Limited
Published: 2012-08-23
Volume: 14
Issue: 2
Pages: 106-111
ISSN: 1399-543X (ISSN-L)
DOI: 10.1111/j.1399-5448.2012.00915.x
PMC: PMC3648791
OpenAlex: W1598677707
Cited by: 106
References: 23
Citations by year: 2026: 5 · 2025: 9 · 2024: 12 · 2023: 8 · 2022: 12 · 2021: 11 · 2020: 9 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 1
FWCI: 3.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1104 d)
Locations: Pediatric Diabetes (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Defense (UL1 RR024153, K24 HD01357, MO1 RR00084, UL1TR000005)
Deutsches Krebsforschungszentrum
National Institutes of Health (UL1TR000005)
U.S. Public Health Service (UL1TR000005, K24 HD01357, UL1 RR024153)
National Center for Research Resources (MO-1-RR-00084, UL1RR024153, M01RR000084)
National Center for Advancing Translational Sciences
Eunice Kennedy Shriver National Institute of Child Health and Human Development (K24HD001357)
Children's Hospital of Pittsburgh
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords: type 2 diabetes, adolescents, beta-cell function, insulin secretion, first-phase insulin secretion, C-peptide, insulin sensitivity, hepatic glucose production, insulin-stimulated glucose disposal, obesity, disease progression, abdominal fat
MeSH terms: Adolescent, Blood Glucose, Body Composition, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Insulin Resistance, Male, Glucose Clamp Technique, Absorptiometry, Photon, Body Mass Index, Insulin-Secreting Cells, Obesity, Abdominal

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Progressive deterioration of β-cell function in obese youth with type 2 diabetes: β-Cell function in youth T2DM

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