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Cited by 173

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

A double‐blind, placebo‐controlled pilot study of quetiapine for depressed adolescents with bipolar disorder

DelBello, Melissa P, Chang, Kiki, Welge, Jeffrey A, Adler, Caleb M, Rana, Manasi, Howe, Meghan, Bryan, Holly, Vogel, Daniel, Sampang, Suzanne, Delgado, Sergio V, Sorter, Michael, Strakowski, Stephen M·2009·Bipolar Disorders
DOI 10.1111/j.1399-5618.2009.00728.x
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Abstract

Objective: To conduct a pilot study comparing the effects of quetiapine and placebo for the treatment of depressive episodes in adolescents with bipolar I disorder. Method: Thirty‐two adolescents (ages 12–18 years) with a depressive episode associated with bipolar I disorder were randomized to eight weeks of double‐blind treatment with quetiapine, 300–600 mg/day, or placebo. This two‐site study was conducted from March 2006 through August 2007. The primary efficacy measure was change in Children’s Depression Rating Scale–Revised Version (CDRS‐R) scores from baseline to endpoint. Secondary efficacy measures included change in CDRS‐R scores over the eight‐week study period (PROC MIXED), changes from baseline to endpoint in Hamilton Anxiety Rating Scale (HAM‐A), Young Mania Rating Scale (YMRS), and Clinical Global Impression–Bipolar Version Severity (CGI‐BP‐S) scores, as well as response and remission rates. Safety and tolerability were assessed weekly. Results: There was no statistically significant treatment group difference in change in CDRS‐R scores from baseline to endpoint (p = 0.89, effect size =−0.05, 95% confidence interval: −0.77–0.68), nor in the average rate of change over the eight weeks of the study (p = 0.95). Additionally, there were no statistically significant differences in response (placebo =67% versus quetiapine = 71%) or remission (placebo = 40% versus quetiapine = 35%) rates, or change in HAM‐A, YMRS, or CGI‐BP‐S scores (all p > 0.7) between treatment groups. Dizziness was more commonly reported in the quetiapine (41%) than in the placebo (7%) group (Fisher’s exact test, p = 0.04). Conclusions: The results suggest that quetiapine monotherapy is no more effective than placebo for the treatment of depression in adolescents with bipolar disorder. However, limitations of the study, including the high placebo response rate, may have contributed to our findings and should be considered in the design of future investigations of pharmacological interventions for this population.

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Metadata

Authors
DelBello, M. P., Chang, K., Welge, J. A., Adler, C. M., Rana, M., Howe, M., Bryan, H., Vogel, D., Sampang, S., Delgado, S. V., Sorter, M., & Strakowski, S. M.
Venue
Bipolar Disorders
Publisher
Wiley
Published
2009-07-10
Volume
11
Issue
5
Pages
483-493
ISSN
  • 1398-5647 (ISSN-L)
  • 1399-5618
DOI
10.1111/j.1399-5618.2009.00728.x
OpenAlex
W2163880309
Cited by
173
References
9
FWCI
8.49
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A double‐blind, placebo‐controlled pilot study of quetiapine for depressed adolescents with bipolar disorder. https://app.cochat.ai/papers/10.1111/j.1399-5618.2009.00728.x
The paper
DelBello, M. P., Chang, K., Welge, J. A., Adler, C. M., Rana, M., Howe, M., Bryan, H., Vogel, D., Sampang, S., Delgado, S. V., Sorter, M., & Strakowski, S. M. (2009). A double‐blind, placebo‐controlled pilot study of quetiapine for depressed adolescents with bipolar disorder. Bipolar Disorders. https://doi.org/10.1111/j.1399-5618.2009.00728.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.