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The Cycling of Calcium, Sodium, and Protons Across the Inner Membrane of Cardiac Mitochondria
Open accessAbstract
A method is described that permits simultaneous determination of the net charge transfer associated with Ca2+ transport by the ruthenium-red-sensitive carrier and the ionized internal [Ca2+] in heart mitochondria. The data indicate that this carrier catalyses a charge-uncompensated flux of Ca2+. Full charge compensation for Ca2+ influx is provided by the respiration-dependent efflux of H+. The net efflux of Ca2+ induced by Na+ is analysed in terms of two other carriers, a Na+-Ca2+ antiporter and a Na+-H+ antiporter. Evidence is presented that these two carriers are separate and that the Na+-H+ exchange is the more rapid. The fluxes of Ca2+, Na+ and H+ during the Na+-induced efflux of Ca2+ support a series of events in which the Na+-H+ exchange enables unidirectional Ca2+ fluxes via the uniport and antiport systems to be integrated into a cycle.
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Citations
Cited by
The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432
Self-citationSensors and regulators of intracellular pH
Casey, J. R., Grinstein, S., & Orlowski, J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2820 · Cited by 2,218
Mechanisms by which mitochondria transport calcium
Gunter, T. E., & Pfeiffer, D. R. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.5.c755 · Cited by 1,640
Mitochondria and neuronal survival
Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243
Role of calcium in the hormonal regulation of liver metabolism
Williamson, J. R., Cooper, R. H., & Hoek, J. B. (1981) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(81)90012-4 · Cited by 317
Metadata
- Authors
- CROMPTON, M., & HEID, I.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1978-11
- Volume
- 91
- Issue
- 2
- Pages
- 599-608
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W2002306733
- Cited by
- 189
- References
- 0
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The Cycling of Calcium, Sodium, and Protons Across the Inner Membrane of Cardiac Mitochondria. https://app.cochat.ai/papers/10.1111/j.1432-1033.1978.tb12713.x
- The paper
- CROMPTON, M., & HEID, I. (1978). The Cycling of Calcium, Sodium, and Protons Across the Inner Membrane of Cardiac Mitochondria. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1978.tb12713.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
