The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Isolation and Characterization of a cDNA from the Rat Brain that Encodes Hemoprotein Heme Oxygenase‐3
Abstract
Two isozymes of heme oxygenase (HO), HO‐1 or HSP32 and the constitutive form HO‐2, have been characterized to date. We report the discovery of a third protein species and refer to it as HO‐3. HO‐3 is the product of a single transcript of ≈2.4 kb and can encode a protein of ≈33 kDa. The HO‐3 transcript is found in the spleen, liver, thymus, prostate, heart, kidney, brain and testis and is the product of a single‐copy gene. The predicted amino acid structure of HO‐3 differs from both HO‐1 (HSP32) and HO‐2 but is closely related to HO‐2 (≈90%). Escherichia coli expressed and purified HO‐3 protein does not cross react with polyclonal antibodies to either rat HO‐1 or HO‐2, is a poor heme catalyst, and displays hemoprotein spectral characteristics. The predicted protein has two heme regulatory motifs that may be involved in heme binding. These motifs and the hemoprotein nature of HO‐3 suggest a potential regulatory role for the protein in cellular processes which are heme‐dependent.
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Cited by
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Wu, L., & Wang, R. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.3 · Cited by 962
Heme oxygenase: colors of defense against cellular stress
Otterbein, L. E., & Choi, A. M. K. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1029 · Cited by 870
Pro-oxidant and cytotoxic effects of circulating heme
Jeney, V., Balla, J., Yachie, A., Varga, Z., Vercellotti, G. M., Eaton, J. W., & Balla, G. (2002) · Blood · doi:10.1182/blood.v100.3.879 · Cited by 633
Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
Ryter, S. W., Otterbein, L. E., Morse, D., & Choi, A. M. K. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015957026924 · Cited by 497
Heme Oxygenase: Recent Advances in Understanding Its Regulation and Role
Elbirt, K. K., & Bonkovsky, H. L. (1999) · Proceedings of the Association of American Physicians · doi:10.1111/paa.1999.111.5.438 · Cited by 308
Metadata
- Authors
- Mccoubrey, W. K., Huang, T. J., & Maines, M. D.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 1997-07
- Volume
- 247
- Issue
- 2
- Pages
- 725-732
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W2056523101
- Cited by
- 823
- References
- 1
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mccoubrey, W. K., Huang, T. J., & Maines, M. D. (1997). Isolation and Characterization of a cDNA from the Rat Brain that Encodes Hemoprotein Heme Oxygenase‐3. European Journal of Biochemistry. https://doi.org/10.1111/j.1432-1033.1997.00725.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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