Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
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Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. HO exists as constitutive (HO-2, HO-3) and inducible isoforms (HO-1), the latter which responds to regulation by multiple stress-stimuli. HO-1 confers protection in vitro and in vivo against oxidative cellular stress. Although the redox active compounds that are generated from HO activity (i.e. iron, biliverdin-IXalpha, and bilirubin-IXa) potentially modulate oxidative stress resistance, increasing evidence points to cytoprotective roles for CO. Though not reactive, CO regulates vascular processes such as vessel tone, smooth muscle proliferation, and platelet aggregation, and possibly functions as a neurotransmitter. The latter effects of CO depend on the activation of guanylate cyclase activity by direct binding to the heme moiety of the enzyme, stimulating the production of cyclic 3':5'-guanosine monophosphate. CO potentially interacts with other intracellular hemoprotein targets, though little is known about the functional significance of such interactions. Recent progress indicates that CO exerts novel anti-inflammatory and anti-apoptotic effects dependent on the modulation of the p38 mitogen activated protein kinase (MAPK)-signaling pathway. By virtue of these effects, CO confers protection in oxidative lung injury models, and likely plays a role in HO-1 mediated tissue protection.
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Bilirubin Is an Antioxidant of Possible Physiological Importance
Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., & Ames, B. N. (1987) · Science · doi:10.1126/science.3029864 · Cited by 3,502 · see citing works
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
Han, J., Lee, J. D., Bibbs, L., & Ulevitch, R. J. (1994) · Science · doi:10.1126/science.7914033 · Cited by 2,647 · see citing works
THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases
Maines, M. D. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.517 · Cited by 2,489 · see citing works
Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,244 · see citing works
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A., & Choi, A. M. K. (2000) · Nature Medicine · doi:10.1038/74680 · Cited by 2,153 · see citing works
Self-citationToll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction
Chow, J. C., Young, D. W., Golenbock, D. T., Christ, W. J., & Gusovsky, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10689 · Cited by 1,924 · see citing works
The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.
Tenhunen, R., Marver, H. S., & Schmid, R. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.61.2.748 · Cited by 1,803 · see citing works
Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications
Maines, M. D. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.10.3290025 · Cited by 1,707 · see citing works
Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606 · see citing works
Carbon Monoxide: a Putative Neural Messenger
Verma, A. M., Hirsch, D. B., Glatt, C. E., Ronnett, G. V., & Snyder, S. H. (1993) · Science · doi:10.1126/science.7678352 · Cited by 1,563 · see citing works
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science · doi:10.1126/science.7839144 · Cited by 1,555 · see citing works
Tenhunen, R., Marver, H. S., & Schmid, R. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63477-5 · Cited by 1,357 · see citing works
Reduced stress defense in heme oxygenase 1-deficient cells
Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10925 · Cited by 1,293 · see citing works
Hentze, M. W., & Kühn, L. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8175 · Cited by 1,292 · see citing works
Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene
Alam, J., Stewart, D. P., Touchard, C. L., Boinapally, S., Choi, A. M. K., & Cook, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26071 · Cited by 1,284 · see citing works
Self-citationRaingeaud, J., Whitmarsh, A. J., Barrett, T., Dérijard, B., & Davis, R. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1247 · Cited by 1,280 · see citing works
Keyse, S. M., & Tyrrell, R. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.1.99 · Cited by 1,271 · see citing works
Role of metals in oxygen radical reactions
Aust, S. D., Morehouse, L. A., & Thomas, C. E. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90025-x · Cited by 1,150 · see citing works
Choi, A. M., & Alam, J. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.15.1.8679227 · Cited by 1,126 · see citing works
Self-citationFerritin: a cytoprotective antioxidant strategem of endothelium.
Balla, G., Jacob, H., Balla, J., Rosenberg, M. E., Nath, K. A., Apple, F., Eaton, J. W., & Vercellotti, G. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37165-0 · Cited by 1,097 · see citing works
Heme oxygenase 1 is required for mammalian iron reutilization
Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10919 · Cited by 1,016 · see citing works
(2006) · Springer eBooks · doi:10.1007/3-540-29832-0_1355 · Cited by 885 · see citing works
Heme oxygenase: colors of defense against cellular stress
Otterbein, L. E., & Choi, A. M. K. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1029 · Cited by 870 · see citing works
Self-citationMcCoubrey, W. K., Huang, T. J., & Maines, M. D. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00725.x · Cited by 823 · see citing works
The heme synthesis and degradation pathways: role in oxidant sensitivity
Ryter, S. W., & Tyrrell, R. M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00223-3 · Cited by 822 · see citing works
Self-citationLee, P. J., Jiang, B.-H., Chin, B. Y., Iyer, N. V., Alam, J., Semenza, G. L., & Choi, A. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5375 · Cited by 782 · see citing works
Self-citationWang, G., & Semenza, G. (1993) · Blood · doi:10.1182/blood.v82.12.3610.3610 · Cited by 766 · see citing works
Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria.
Freeman, B. Α., & Crapo, J. D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68544-3 · Cited by 762 · see citing works
Maines, M. D., Trakshel, G. M., & Kutty, R. K. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42488-4 · Cited by 759 · see citing works
Biological Roles of Nitric Oxide
Snyder, S. H., & Bredt, D. S. (1992) · Scientific American · doi:10.1038/scientificamerican0592-68 · Cited by 726 · see citing works
Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.
Morita, T., Perrella, M. A., Lee, M. E., & Kourembanas, S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1475 · Cited by 707 · see citing works
Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat.
Nath, K. A., Balla, G., Vercellotti, G. M., Balla, J., Jacob, H. S., Levitt, M. D., & Rosenberg, M. E. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115847 · Cited by 685 · see citing works
PULMONARY OXYGEN TOXICITY: A REVIEW
Clark, J. M., & Lambertsen, C. J. (1971) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06887-5 · Cited by 654 · see citing works
Stone, J. R., & Marletta, M. A. (1994) · Biochemistry · doi:10.1021/bi00184a036 · Cited by 647 · see citing works
Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells.
Applegate, L. A., Lüscher, P., & Tyrrell, R. M. (1991) · PubMed · Cited by 636 · see citing works
Heme oxygenase-1 protects against vascular constriction and proliferation
Duckers, H. J., Boehm, M., True, A. L., Yet, S., San, H., Park, J. L., Webb, R. C., Lee, M.-E., Nabel, G. J., & Nabel, E. G. (2001) · Nature Medicine · doi:10.1038/89068 · Cited by 524 · see citing works
Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts.
Vile, G. F., Modak, S. B., Waltner, C., & Tyrrell, R. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.7.2607 · Cited by 517 · see citing works
Haem oxygenase-1 prevents cell death by regulating cellular iron
Ferris, C. D., Jaffrey, S. R., Sawa, A., Takahashi, M., Brady, S. D., Barrow, R. K., Tysoe, S. A., Wolosker, H., Barañano, D. E., Doré, S., et al. (1999) · Nature Cell Biology · doi:10.1038/11072 · Cited by 509 · see citing works
Otterbein, L. E., Kolls, J. K., Mantell, L. L., Cook, J. L., Alam, J., & Choi, A. M. K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5342 · Cited by 492 · see citing works
Self-citationIdentification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein
He, C. H., Gong, P., Hu, B., Stewart, D., Choi, M. E., Choi, A. M. K., & Alam, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101198200 · Cited by 472 · see citing works
Self-citationFurchgott, R. F., & Jothianandan, D. (2008) · Blood Vessels · doi:10.1159/000158843 · Cited by 471 · see citing works
Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.
Hambleton, J., Weinstein, S. L., Lem, L., & DeFranco, A. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2774 · Cited by 471 · see citing works
Reversal of HO‐1 related cytoprotection with increased expression is due to reactive iron
Suttner, D. M., & Dennery, P. A. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.13.1800 · Cited by 426 · see citing works
Transcriptional control of rat heme oxygenase by heat shock.
Shibahara, S., Müller, R., & Taguchi, H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45138-1 · Cited by 415 · see citing works
Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice
Yet, S., Perrella, M. A., Layne, M. D., Hsieh, C.-M., Maemura, K., Kobzik, L., Wiesel, P., Christou, H. A., Kourembanas, S., & Lee, M.-E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6163 · Cited by 407 · see citing works
Vile, G. F., & Tyrrell, R. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82386-9 · Cited by 406 · see citing works
Mechanism of Heme Oxygenase-1 Gene Activation by Cadmium in MCF-7 Mammary Epithelial Cells
Alam, J., Wicks, C., Stewart, D., Gong, P., Touchard, C. L., Otterbein, S. L., Choi, A. M. K., Burow, M. E., & Tou, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004729200 · Cited by 406 · see citing works
Self-citationZakhary, R., Gaine, S., DINERMAN, J. L., Ruat, M., Flavahan, N. A., & Snyder, S. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.795 · Cited by 401 · see citing works
Fujita, T., Toda, K., Karimova, A., Yan, S., Naka, Y., Yet, S., & Pinsky, D. J. (2001) · Nature Medicine · doi:10.1038/87929 · Cited by 399 · see citing works
Minamino, T., Christou, H. A., Hsieh, C.-M., Liu, Y., Dhawan, V., Abraham, N. G., Perrella, M. A., Mitsialis, S. A., & Kourembanas, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161272598 · Cited by 366 · see citing works
Neurons Overexpressing Heme Oxygenase‐1 Resist Oxidative Stress‐Mediated Cell Death
Chen, K., Gunter, K. K., & Maines, M. D. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750304.x · Cited by 356 · see citing works
Morita, T., & Kourembanas, S. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118334 · Cited by 354 · see citing works
Lee, P. J., Alam, J., Wiegand, G. W., & Choi, A. M. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10393 · Cited by 346 · see citing works
Self-citationYu, R., Chen, C., Mo, Y.-Y., Hebbar, V., Owuor, E. D., Tan, T., & Kong, A.-N. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004037200 · Cited by 341 · see citing works
Metals as Regulators of Heme Metabolism
Maines, M. D., & Kappas, A. (1977) · Science · doi:10.1126/science.337492 · Cited by 339 · see citing works
Abraham, N. G., Lavrovsky, Y., Schwartzman, M. L., Stoltz, R. A., Levere, R. D., Gerritsen, M. E., Shibahara, S., & Kappas, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6798 · Cited by 338 · see citing works
Carbon Monoxide Controls the Proliferation of Hypoxic Vascular Smooth Muscle Cells
Morita, T., Mitsialis, S. A., Koike, H., Liu, Y., & Kourembanas, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32804 · Cited by 332 · see citing works
Juan, S., Lee, T., Tseng, K., Liou, J., Shyue, S., Wu, K. K., & Chau, L. (2001) · Circulation · doi:10.1161/hc3801.095663 · Cited by 331 · see citing works
Durante, W., Kroll, M. H., Christodoulides, N., Peyton, K. J., & Schafer, A. I. (1997) · Circulation Research · doi:10.1161/01.res.80.4.557 · Cited by 329 · see citing works
Motterlini, R., Foresti, R., Intaglietta, M., & Winslow, R. M. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.1.h107 · Cited by 317 · see citing works
Human heme oxygenase cDNA and induction of its mRNA by hemin
Yoshida, T., Peter, B. I. R. O., Cohen, T., Müller, R., & Shibahara, S. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb13811.x · Cited by 317 · see citing works
Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.
Eisenstein, R. S., García-Mayol, D., Pettingell, W. H., & Munro, H. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.3.688 · Cited by 308 · see citing works
Hemoglobin Provides Protection Against Lethal Endotoxemia in Rats: The Role of Heme Oxygenase-1
Otterbein, L. E., Sylvester, S. L., & Choi, A. M. K. (1995) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.13.5.7576696 · Cited by 308 · see citing works
Self-citationHeme Oxygenase-1 Inhibits Atherosclerotic Lesion Formation in LDL-Receptor Knockout Mice
Ishikawa, K., Sugawara, D., Wang, X.-P., Suzuki, K., Itabe, H., Maruyama, Y., & Lusis, A. J. (2001) · Circulation Research · doi:10.1161/01.res.88.5.506 · Cited by 296 · see citing works
Foresti, R., Clark, J., Green, C. J., & Motterlini, R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.18411 · Cited by 294 · see citing works
Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts
Petrache, I., Otterbein, L. E., Alam, J., Wiegand, G. W., & Choi, A. M. K. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.278.2.l312 · Cited by 293 · see citing works
Self-citationEvidence suggesting that the two forms of heme oxygenase are products of different genes.
CRUSE, I., & Maines, M. D. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69078-7 · Cited by 287 · see citing works
Siow, R. C. M. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00278-8 · Cited by 274 · see citing works
Tenhunen, R., Ross, M. E., Marver, H. S., et al. (1970) · Biochemistry · doi:10.1021/bi00804a016 · Cited by 265 · see citing works
Ewing, J. F., & Maines, M. D. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.12.5364 · Cited by 264 · see citing works
Gorman, A. A., & Rodgers, M. A. J. (1981) · Chemical Society Reviews · doi:10.1039/cs9811000205 · Cited by 264 · see citing works
Endothelial Heme Oxygenase-1 Induction by Hypoxia
Motterlini, R., Foresti, R., Bassi, R., Calabrese, V., Clark, J., & Green, C. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13613 · Cited by 261 · see citing works
Heme Oxygenase: Clinical Applications and Functions
Maines, M. D. (1992) · Medical Entomology and Zoology · Cited by 260 · see citing works
Induction of Heme Oxygenase-1 Gene Expression by Lipopolysaccharide is Mediated by AP-1 Activation
Camhi, S. L., Alam, J., Otterbein, L. E., Sylvester, S. L., & Choi, A. M. K. (1995) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.13.4.7546768 · Cited by 257 · see citing works
Self-citationExpression of heme oxygenase-1 in atherosclerotic lesions.
Wang, L.-J., Lee, T., Lee, F.-Y., Pai, R., & Chau, L. (1998) · Europe PMC (PubMed Central) · Cited by 254 · see citing works
Mechanism of Sodium Arsenite-mediated Induction of Heme Oxygenase-1 in Hepatoma Cells
Elbirt, K. K., Whitmarsh, A. J., Davis, R. J., & Bonkovsky, H. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8922 · Cited by 252 · see citing works
The enzymic reduction and kinetics of oxidation of cytochrome b.245 of neutrophils
Cross, A. R., Higson, F. K., Jones, O. T. G., Harper, A., & Segal, A. W. (1982) · Biochemical Journal · doi:10.1042/bj2040479 · Cited by 246 · see citing works
Activation of mammalian gene expression by the UV component of sunlight – from models to reality
Tyrrell, R. M. (1996) · BioEssays · doi:10.1002/bies.950180210 · Cited by 233 · see citing works
Transcriptional Activation of the Heme Oxygenase Gene by Heme and Cadmium in Mouse Hepatoma Cells
Alam, J., Shibahara, S., & Smith, A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83358-0 · Cited by 226 · see citing works
Keyse, S. M., Applegate, L. A., Tromvoukis, Y., & Tyrrell, R. M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.9.4967 · Cited by 226 · see citing works
Keyse, S. M., & Tyrrell, R. M. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47869-6 · Cited by 221 · see citing works
Alam, J., Camhi, S. L., & Choi, A. M. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.11977 · Cited by 219 · see citing works
Self-citationLautier, D., Lüscher, P., & Tyrrell, R. M. (1992) · Carcinogenesis · doi:10.1093/carcin/13.2.227 · Cited by 216 · see citing works
Induction of four proteins in chick embryo cells by sodium arsenite.
Johnston, D., Oppermann, H., Jackson, J., et al. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43671-x · Cited by 215 · see citing works
Regulation of Heme Oxygenase-1 Expression In Vivo and In Vitro in Hyperoxic Lung Injury
Lee, P. J., Alam, J., Sylvester, S. L., et al. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.14.6.8652184 · Cited by 213 · see citing works
Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2.
Dennery, P. A., Spitz, D. R., Yang, G., Tatarov, A., Lee, C. S., Shegog, M., & Poss, K. D. (1998) · Journal of Clinical Investigation · doi:10.1172/jci448 · Cited by 212 · see citing works
Heme protein-induced chronic renal inflammation: Suppressive effect of induced heme oxygenase-1
Nath, K. A., Vercellotti, G. M., Grande, J. P., Miyoshi, H., Payá, C. V., Manivel, J. C., Haggard, J. J., Croatt, A. J., Payne, W. D., & Alam, J. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00471.x · Cited by 211 · see citing works
Effects of acidosis on phosphorylation of phospholamban and troponin I in rat cardiac muscle
Mundiña‐Weilenmann, C., Vittone, L., Cingolani, H. E., & Orchard, C. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.270.1.c107 · Cited by 211 · see citing works
Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis
Foresti, R., Sarathchandra, P., Clark, J., Green, C. J., & Motterlini, R. (1999) · Biochemical Journal · doi:10.1042/bj3390729 · Cited by 209 · see citing works
Nucleotide sequence and organization of the rat heme oxygenase gene.
Müller, R., Taguchi, H., & Shibahara, S. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48315-9 · Cited by 207 · see citing works
Basis of guanylate cyclase activation by carbon monoxide.
Kharitonov, V. G., Sharma, V., Pilz, R. B., Magde, D., & Koesling, D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2568 · Cited by 207 · see citing works
Modak, S. B., & Tyrrell, R. M. (1993) · PubMed · Cited by 205 · see citing works
Christou, H. A., Morita, T., Hsieh, C.-M., Koike, H., Arkonac, B. M., Perrella, M. A., & Kourembanas, S. (2000) · Circulation Research · doi:10.1161/01.res.86.12.1224 · Cited by 204 · see citing works
Ewing, J. F., Haber, S. N., & Maines, M. D. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09373.x · Cited by 196 · see citing works
Alam, J., & Den, Z. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36696-7 · Cited by 195 · see citing works
Inamdar, N. M., Ahn, Y. I., & Alam, J. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0637 · Cited by 194 · see citing works
Singlet Molecular Oxygen (1O2): A Possible Effector of Eukaryotic Gene Expression
Ryter, S. W., & Tyrrell, R. M. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00461-9 · Cited by 193 · see citing works
Self-citationAdaptive responses and apoptosis in endothelial cells exposed to carbon monoxide
Thom, S. R., Fisher, D., Xu, Y., Notarfrancesco, K., & Ischiropoulos, H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1305 · Cited by 192 · see citing works
Wood, S. M., Wiesener, M. S., Yeates, K. M., Okada, N., Pugh, C. W., Maxwell, P. H., & Ratcliffe, P. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.8360 · Cited by 189 · see citing works
Intracellular acidification induced by passive and active transport of ammonium ions in astrocytes
Nagaraja, T. N., & Brookes, N. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.4.c883 · Cited by 186 · see citing works
Otterbein, L. E., Otterbein, S. L., Ifedigbo, E., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63610-3 · Cited by 185 · see citing works
Self-citationTerry, C. M., Clikeman, J. A., Hoidal, J. R., & Callahan, K. S. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.3.h883 · Cited by 182 · see citing works
Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide
Hartsfield, C. L., Alam, J., Cook, J. L., & Choi, A. M. K. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.273.5.l980 · Cited by 176 · see citing works
Self-citationSardana, M. K., & Kappas, A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2464 · Cited by 169 · see citing works
Acquired resistance to acute oxidative stress. Possible role of heme oxygenase and ferritin.
Vogt, B. A., Alam, J., Croatt, A. J., Vercellotti, G. M., & Nath, K. A. (1995) · PubMed · Cited by 168 · see citing works
The human 32‐kDa stress protein induced by exposure to arsenite and cadmium ions is heme oxygenase
Taketani, S., Kohno, H., Yoshinaga, T., & Tokunaga, R. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80215-7 · Cited by 164 · see citing works
Carbon monoxide and cerebral microvascular tone in newborn pigs
Leffler, C. W., Nasjletti, A., Yu, C., Johnson, R. A., Fedinec, A. L., & Walker, N. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.5.h1641 · Cited by 158 · see citing works
Cantoni, L., Rossi, C., Rizzardini, M., et al. (1991) · Biochemical Journal · doi:10.1042/bj2790891 · Cited by 155 · see citing works
Carbon Monoxide as an Endogenous Modulator of Hepatic Vascular Perfusion
Suematsu, M., Kashiwagi, S., Sano, T., et al. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2811 · Cited by 154 · see citing works
Alam, J., Cai, J., & Smith, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42211-3 · Cited by 152 · see citing works
In vivo binding of carbon monoxide to cytochrome c oxidase in rat brain
Brown, S. D., & Piantadosi, C. A. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.68.2.604 · Cited by 146 · see citing works
Rizzardini, M., Terao, M., Falciani, F., et al. (1993) · Biochemical Journal · doi:10.1042/bj2900343 · Cited by 144 · see citing works
Structural organization of the human heme oxygenase gene and the function of its promoter
Shibahara, S., Sato, M., Müller, R., et al. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb14583.x · Cited by 143 · see citing works
Caltabiano, M. M., Koestler, T. P., Poste, G. H., et al. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69316-0 · Cited by 137 · see citing works
Regulation of human heme oxygenase-1 gene expression under thermal stress
Okinaga, S., Takahashi, K., Takeda, K., et al. (1996) · Blood · doi:10.1182/blood.v87.12.5074.bloodjournal87125074 · Cited by 135 · see citing works
Nitric Oxide-inducible Expression of Heme Oxygenase-1 in Human Cells
Bouton, C., & Demple, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.42.32688 · Cited by 134 · see citing works
Characterization of the enzyme
Moore, M. J. (1994) · Cited by 134 · see citing works
Camhi, S. L., Alam, J., Wiegand, G. W., Chin, B. Y., & Choi, A. M. K. (1998) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.18.2.2910 · Cited by 130 · see citing works
Self-citationEwing, J. F., Raju, V. S., & Maines, M. D. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22706-9 · Cited by 130 · see citing works
Yoshida, T., Noguchi, M., & Kikuchi, G. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85506-0 · Cited by 129 · see citing works
Iron loading of endothelial cells augments oxidant damage.
Balla, G., Vercellotti, G. M., Eaton, J. W., & Jacob, H. S. (1990) · PubMed · Cited by 127 · see citing works
Alam, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31496-5 · Cited by 127 · see citing works
Terry, C. M., Clikeman, J. A., Hoidal, J. R., & Callahan, K. S. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.5.h1493 · Cited by 127 · see citing works
Raju, V. S., McCoubrey, W. K., & Maines, M. D. (1997) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(96)00183-2 · Cited by 126 · see citing works
Meyrick, B. O., & Reid, L. (1983) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(21)00199-4 · Cited by 125 · see citing works
Murphy, B. J., Laderoute, K. R., Short, S., & Sutherland, R. J. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.241 · Cited by 125 · see citing works
Tyrrell, R. M., & Pidoux, M. (1988) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1988.tb02744.x · Cited by 125 · see citing works
Keyse, S. M., & Tyrrell, R. M. (1990) · Carcinogenesis · doi:10.1093/carcin/11.5.787 · Cited by 124 · see citing works
Suttner, D. M., Sridhar, K. J., Lee, C. S., et al. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.276.3.l443 · Cited by 124 · see citing works
Guengerich, F. P., Ballou, D. P., & Coon, M. J. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40959-9 · Cited by 122 · see citing works
Rattan, S. C., & Chakder, S. (1993) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1993.265.4.g799 · Cited by 122 · see citing works
Enzymic degradation of heme. Oxygenative cleavage requiring cytochrome P-450
Tenhunen, R., Marver, H. S., Pinstone, N. R., et al. (1972) · Biochemistry · doi:10.1021/bi00759a029 · Cited by 121 · see citing works
Kutty, R. K., Nagineni, C. N., Kutty, G., et al. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041590221 · Cited by 119 · see citing works
Induction characteristics of oxygen regulated proteins
Heacock, C. S., & Sutherland, R. M. (1986) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(86)90155-0 · Cited by 119 · see citing works
AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1
Lee, P. J., Camhi, S. L., Chin, B. Y., et al. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.1.l175 · Cited by 114 · see citing works
Tyrrell, R. M., & Pidoux, M. (1986) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1986.tb04709.x · Cited by 113 · see citing works
Induction of heme oxygenase-1 by hypoxia and free radicals in human dermal fibroblasts
Panchenko, M. V., Farber, H. W., & Korn, J. H. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.1.c92 · Cited by 113 · see citing works
Interaction of heme oxygenase‐2 with nitric oxide donors
Ding, Y., McCoubrey, W. K., & Maines, M. D. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00677.x · Cited by 107 · see citing works
Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38.
Chen, K., & Maines, M. D. (2000) · PubMed · Cited by 106 · see citing works
Carbon monoxide and vascular cell function (review).
Durante, W., & Schafer, A. I. (1998) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2.3.255 · Cited by 106 · see citing works
Coburn, R. F., & Forman, H. J. (1987) · Comprehensive physiology · doi:10.1002/cphy.cp030421 · Cited by 105 · see citing works
Rizzardini, M., Carelli, M., Porras, M. R. C., & Cantoni, L. (1994) · Biochemical Journal · doi:10.1042/bj3040477 · Cited by 103 · see citing works
Takahashi, K., Hara, E., Suzuki, H., et al. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67020482.x · Cited by 97 · see citing works
Gomer, C. J., Luna, M., Ferrario, A., et al. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb03934.x · Cited by 96 · see citing works
Hypoxia induces a specific set of stress proteins in cultured endothelial cells.
Zimmerman, L. H., Levine, R. A., & Farber, H. W. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115097 · Cited by 91 · see citing works
Cobalt regulation of heme synthesis and degradation in avian embryo liver cell culture.
Maines, M. D., & Sinclair, P. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32819-3 · Cited by 90 · see citing works
Parathyroid-hormone-related protein in sarcoidosis.
Zeimer, H., Greenaway, T. M., Slavin, J. L., et al. (1998) · PubMed · Cited by 89 · see citing works
Smith, A. L., Alam, J., Escribá, P. V., & Morgan, W. T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53184-7 · Cited by 83 · see citing works
Kacimi, R. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00007-9 · Cited by 82 · see citing works
Katayose, D., Isoyama, S., Fujita, H., et al. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1258 · Cited by 82 · see citing works
Carbon Monoxide in Breath, Blood, and Other Tissues
Vreman, H. J., Wong, R. J., & Stevenson, D. K. (2000) · CRC Press eBooks · doi:10.1201/9781420039320.ch2 · Cited by 82 · see citing works
Heme oxygenase is a positive acute-phase reactant in human Hep3B hepatoma cells
Mitani, K., Fujita, H., Kappas, A., et al. (1992) · Blood · doi:10.1182/blood.v79.5.1255.1255 · Cited by 79 · see citing works
Gene Expression in Low Oxygen Tension
Helfman, T., & Falanga, V. (1993) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199307000-00010 · Cited by 78 · see citing works
Effect of nitric oxide on heme metabolism in pulmonary artery endothelial cells
Yee, E., Pitt, B. R., Billiar, T. R., et al. (1996) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1996.271.4.l512 · Cited by 78 · see citing works
Kurata, S., Matsumoto, M., Tsuji, Y., et al. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0566u.x · Cited by 77 · see citing works
The Potent Heme Oxygenase Inducing Action of Arsenic and Parasiticidal Arsenicals
Sardana, M. K., Drummond, G. S., Sassa, S., et al. (2008) · Pharmacology · doi:10.1159/000137557 · Cited by 77 · see citing works
Raju, V. S., & Maines, M. D. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13138-8 · Cited by 76 · see citing works
Durante, W., Peyton, K. J., & Schafer, A. I. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.11.2666 · Cited by 76 · see citing works
Yoshida, T., Noguchi, M., & Kikuchi, G. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34075-4 · Cited by 73 · see citing works
Kageyama, H., Hiwasa, T., Tokunaga, K., et al. (1988) · PubMed · Cited by 71 · see citing works
Maines, M. D., Eke, B. C., & Zhao, X. (1996) · Brain Research · doi:10.1016/0006-8993(96)00184-9 · Cited by 71 · see citing works
Nitric Oxide-mediated Vasorelaxation
Ignarro, L. J. (1993) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646177 · Cited by 70 · see citing works
Enhancement of heme oxygenase-1 synthesis by glutathione depletion in Chinese hamster ovary cells
Saunders, E. L., Maines, M. D., Meredith, M. J., & Freeman, M. L. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90208-z · Cited by 69 · see citing works
Role of endothelial carbon monoxide in attenuated vasoreactivity following chronic hypoxia
Caudill, T. K., Resta, T. C., Kanagy, N. L., & Walker, B. R. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.4.r1025 · Cited by 69 · see citing works
SHARMA, H. S., Maulik, N., Gho, B. C. G., et al. (1996) · Molecular and Cellular Biochemistry · doi:10.1007/bf00227888 · Cited by 67 · see citing works
Raju, V. S., & Maines, M. D. (1994) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(94)90286-0 · Cited by 65 · see citing works
Ryter, S. W., Xi, S., Hartsfield, C. L., & Choi, A. M. K. (2002) · Antioxidants and Redox Signaling · doi:10.1089/15230860260220085 · Cited by 64 · see citing works
Self-citationDifferential signaling pathways ofHO-1gene expression in pulmonary and systemic vascular cells
Hartsfield, C. L., Alam, J., & Choi, A. M. K. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.6.l1133 · Cited by 63 · see citing works
Self-citationMitani, K., Fujita, H., Fukuda, Y., et al. (1993) · Biochemical Journal · doi:10.1042/bj2900819 · Cited by 62 · see citing works
Fogg, S., Agarwal, A., Nick, H. S., & Visner, G. A. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.4.3477 · Cited by 61 · see citing works
Stimulation of heme oxygenase in macrophages and liver by endotoxin.
Gemsa, D., Woo, C. H., Fudenberg, H. H., et al. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107599 · Cited by 60 · see citing works
Regulation of heme oxygenase gene expression by cobalt in rat liver and kidney
LIN, J. H. ‐., Villalon, P., Martásek, P., et al. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb19263.x · Cited by 58 · see citing works
Wang, G., & Semenza, G. (1993) · Blood · doi:10.1182/blood.v82.12.3610.bloodjournal82123610 · Cited by 57 · see citing works
Kvam, E., Hejmadi, V., Ryter, S. W., Pourzand, C., & Tyrrell, R. M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00205-7 · Cited by 56 · see citing works
Self-citationGong, Q., & Hart, B. A. (1997) · Toxicology · doi:10.1016/s0300-483x(96)03608-6 · Cited by 56 · see citing works
Keyse, S. M., Applegate, T. L. A., Tromvoukis, Y., et al. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.9.4967-4969.1990 · Cited by 53 · see citing works
Complex genetic response of human cells to sublethal levels of pure nitric oxide.
Marquis, J. C., & Demple, B. (1998) · PubMed · Cited by 52 · see citing works
Taketani, S., Sato, H., Yoshinaga, T., et al. (1990) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a123156 · Cited by 51 · see citing works
Translational regulation of ferritin synthesis by iron.
Eisenstein, R., & Munro, H. (1990) · Enzyme · doi:10.1159/000468746 · Cited by 49 · see citing works
Okinaga, S., & SHBAHARA, S. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17647.x · Cited by 49 · see citing works
Heme Oxygenase-2 Interaction with Metalloporphyrins: Function of Heme Regulatory Motifs
Huang, T. J., McCoubrey, W. K., & Maines, M. D. (2001) · Antioxidants and Redox Signaling · doi:10.1089/15230860152543023 · Cited by 49 · see citing works
Regulation of endothelial heme oxygenase activity during hypoxia is dependent on chelatable iron
Ryter, S. W., Si, M.-L., Lai, C., & Su, C.-Y. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.6.h2889 · Cited by 49 · see citing works
Self-citationInduction of heme oxygenase in rat hepatoma cells by exposure to heavy metals and hyperthermia.
Taketani, S., Kohno, H., Yoshinaga, T., et al. (1988) · PubMed · Cited by 49 · see citing works
Kvam, E., Noel, A., Modak, S. B., & Tyrrell, R. M. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00224-x · Cited by 47 · see citing works
Borger, D. R., & Essig, D. A. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.3.h965 · Cited by 46 · see citing works
Activation of heme oxygenase and heat shock protein 70 genes by stress in human hepatoma cells
Mitani, K., Fujita, H., Sassa, S., et al. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91026-o · Cited by 45 · see citing works
Endothelial cell hypoxic stress proteins
Graven, K. K., & Farber, H. W. (1998) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(98)90122-6 · Cited by 42 · see citing works
Kappas, A., & Drummond, G. S. (1984) · Environmental Health Perspectives · doi:10.1289/ehp.8457301 · Cited by 42 · see citing works
Hiwasa, T., & Sakiyama, S. (1986) · PubMed · Cited by 41 · see citing works
STEVENSON, T. H., Gutiérrez, A., ALDERTON, W. K., Lian, L., & Scrutton, N. S. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580201 · Cited by 41 · see citing works
Tumor promoters increase the synthesis of a 32,000-dalton protein in BALB/c 3T3 cells.
Hiwasa, T., Fujimura, S., & Sakiyama, S. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.6.1800 · Cited by 40 · see citing works
Iron and Gene Expression: Molecular Mechanisms Regulating Cellular Iron Homeostasis
Kühn, L. C. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01681.x · Cited by 40 · see citing works
Hyperoxic Regulation of Lung Heme Oxygenase in Neonatal Rats
Dennery, P. A., Rodgers, P. A., Lum, M. A., Jennings, B. C., & Shokoohi, V. (1996) · Pediatric Research · doi:10.1203/00006450-199612000-00007 · Cited by 38 · see citing works
Volpe, J. A., O'Toole, M. C., & Caughey, W. S. (1975) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(75)80403-7 · Cited by 36 · see citing works
Glutathione conjugation and induction of a 32,000 dalton stress protein
Freeman, M. L., & Meredith, M. J. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90040-3 · Cited by 35 · see citing works
Heme Oxygenase-Dependent Carbon Monoxide Production Is a Hepatic Adaptive Response to Sepsis
Downard, P. J., Wilson, M. A., Spain, D. A., et al. (1997) · Journal of Surgical Research · doi:10.1006/jsre.1997.5135 · Cited by 35 · see citing works
Fukuda, Y., & Sassa, S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1623 · Cited by 34 · see citing works
Evidence that glutathione participates in the induction of a stress protein
Shelton, K. R., Egle, P. M., & Todd, J. M. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(86)80447-8 · Cited by 33 · see citing works
Approaches to Define Pathways of Redox Regulation of a Eukaryotic Gene: The Heme Oxygenase 1 Example
Tyrrell, R. M. (1997) · Methods · doi:10.1006/meth.1996.0425 · Cited by 31 · see citing works
Clinical aspects of hypoxic pulmonary vasoconstriction
Leach, R., & Treacher, D. (1995) · Experimental Physiology · doi:10.1113/expphysiol.1995.sp003894 · Cited by 31 · see citing works
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Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works
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Marcinkiewicz, J., & Kontny, E. (2014) · Amino Acids · doi:10.1007/s00726-012-1361-4 · Cited by 531 · see citing works
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Gladwin, M. T., & Vichinsky, E. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0804411 · Cited by 470 · see citing works
Kato, G. J., Hebbel, R. P., Steinberg, M. H., & Gladwin, M. T. (2009) · American Journal of Hematology · doi:10.1002/ajh.21475 · Cited by 349 · see citing works
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NATH, K. A., KATUSIC, Z. S., & GLADWIN, M. T. (2004) · Microcirculation · doi:10.1080/10739680490278592 · Cited by 102 · see citing works
Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injury
Cole, M. P., Rudolph, T. K., Khoo, N. K. H., Motanya, U. N., Golin-Bisello, F., Wertz, J. W., Schopfer, F. J., Rudolph, V., Woodcock, S. R., Bolisetty, S., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.199075 · Cited by 69 · see citing works
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Gladwin, M. T. (2007) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-387-34817-9_17 · Cited by 59 · see citing works
Ali, D., Mohammad, D. K., Mujahed, H., Jonson‐Videsäter, K., Nore, B., Paul, C., & Lehmann, S. (2016) · British Journal of Haematology · doi:10.1111/bjh.14036 · Cited by 49 · see citing works
- Authors
- Ryter, S. W., Otterbein, L. E., Morse, D., & Choi, A. M. K.
- Affiliations
- University of Pittsburgh Medical Center (US)
- Corresponding author
- Ryter, Stefan W.
- Venue
- Molecular and Cellular Biochemistry
- Published
- 2002-05
- Volume
- 234-235
- Issue
- 1
- Pages
- 249-263
- ISSN
- 0300-8177 (ISSN-L)
- 1573-4919
- PMC
- PMC7101540
- OpenAlex
- W2171750543
- Cited by
- 497
- References
- 213
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 13 · 2022: 12 · 2021: 12 · 2020: 21 · 2019: 6 · 2018: 14 · 2017: 25 · 2016: 19 · 2015: 19 · 2014: 29 · 2013: 28 · 2012: 26
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular and Cellular Biochemistry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- carbon monoxide, heme oxygenase, heme oxygenase-1, heme oxygenase-2, oxidative stress, biliverdin, bilirubin, guanylate cyclase, cyclic GMP, cytoprotection, anti-inflammatory activity, anti-apoptotic effects, p38 MAPK signaling, oxidative lung injury, vascular tone, platelet aggregation, neurotransmitters
- MeSH terms
- Animals, Anti-Inflammatory Agents, Carbon Monoxide, Heme Oxygenase (Decyclizing), Humans, Inflammation, Isoenzymes, Stress, Physiological, Signal Transduction, Gene Expression Regulation, Enzymologic, Oxidative Stress
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