The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Principles behind the multifarious control of signal transduction: ERK phosphorylation and kinase/phosphatase control
Open accessAbstract
General and simple principles are identified that govern signal transduction. The effects of kinase and phosphatase inhibition on a MAP kinase pathway are first examined in silico. Quantitative measures for the control of signal amplitude, duration and integral strength are introduced. We then identify and prove new principles, such that total control on signal amplitude and on final signal strength must amount to zero, and total control on signal duration and on integral signal intensity must equal −1. Collectively, kinases control amplitudes more than duration, whereas phosphatases tend to control both. We illustrate and validate these principles experimentally: (a) a kinase inhibitor affects the amplitude of EGF‐induced ERK phosphorylation much more than its duration and (b) a phosphatase inhibitor influences both signal duration and signal amplitude, in particular long after EGF administration. Implications for the cellular decision between growth and differentiation are discussed.
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Mutations of the BRAF gene in human cancer
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674
Network motifs: simple building blocks of complex networks.
Milo, R., Shen-Orr, S., Itzkovitz, S., Kashtan, N., Chklovskii, D., & Alon, U. (2002) · Science · doi:10.1126/science.298.5594.824 · Cited by 7,368
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Huang, C. Y., & Ferrell, J. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10078 · Cited by 1,186
Metabolic control analysis: a survey of its theoretical and experimental development
Fell, D. A. (1992) · Biochemical Journal · doi:10.1042/bj2860313 · Cited by 782
Swameye, I., Müller, T. G., Timmer, J., Sandra, O., & Klingmüller, U. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0237333100 · Cited by 316
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Cell-signalling dynamics in time and space
Kholodenko, B. N. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1838 · Cited by 1,347
Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
Junttila, M. R., Li, S., & Westermarck, J. (2008) · The FASEB Journal · doi:10.1096/fj.06-7859rev · Cited by 826
Bruggeman, F. J., & Westerhoff, H. V. (2007) · Trends in Microbiology · doi:10.1016/j.tim.2006.11.003 · Cited by 531
Self-citationCancer: A Systems Biology disease
Hornberg, J. J., Bruggeman, F. J., Westerhoff, H. V., & Lankelma, J. (2006) · Biosystems · doi:10.1016/j.biosystems.2005.05.014 · Cited by 381
Self-citationMaggio, C. A., & Pi-Sunyer, F. X. (2003) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(03)00071-9 · Cited by 351
Metadata
- Authors
- Hornberg, J. J., Bruggeman, F. J., Binder, B., Geest, C. R., de Vaate, A. J. M. B., Lankelma, J., Heinrich, R., & Westerhoff, H. V.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2004-12-02
- Volume
- 272
- Issue
- 1
- Pages
- 244-258
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W1538631790
- Cited by
- 166
- References
- 5
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hornberg, J. J., Bruggeman, F. J., Binder, B., Geest, C. R., de Vaate, A. J. M. B., Lankelma, J., Heinrich, R., & Westerhoff, H. V. (2005). Principles behind the multifarious control of signal transduction: ERK phosphorylation and kinase/phosphatase control. The FEBS Journal. https://doi.org/10.1111/j.1432-1033.2004.04404.x
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