The DOI matches its Crossref record.
Effectiveness of low-dose cotrimoxazole prophylaxis against Pneumocystis carinii pneumonia after renal and/or pancreas transplantation
Abstract
Abstract. We retrospectively examined the effectiveness of prophylaxis with cotrimoxazole in preventing Pneumocystis carnii pneumonia in recipients of kidney and combined kidney-pancreas transplants between 1985 and 1989. Cotrimoxazole prophylaxis (480 mg daily or 300 mg/m2), when used, was started within 2 months after transplantation and usually continued until 6 months after surgery. Eight (3.7%) of the 214 patients who were not given prophylaxis were infected with Pneumocystis carinii, and there were 4 fatalities (50% mortality). There were no cases among the 161 patients given prophylaxis (P≤ 0.03). No serious adverse effects were noted in the prophylaxis group. It is concluded that prophylaxis against Pneumocystis carinii infection is well tolerated and should be given as soon as possible to all organ transplant recipients for at least 6 months.
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Kidney transplant recipients are routinely prescribed cotrimoxazole prophylaxis to prevent infections caused by Pneumocystis jirovecii.
“transplant recipients are routinely prescribed cotrimoxazole prophylaxis to prevent infections caused by Pneumocystis jirovecii (PCP) [22,24].”
From Pharmacometabolomics Study of Sulfamethoxazole and Trimethoprim in Kidney Transplant Recipients: Real-World Metabolism and Urinary Excretion (2025) · cites this paper as [22]
Immunosuppressed humans receive cotrimoxazole prophylactically for a longer period.
“immunosuppressed humans represent an interesting study domain as these individuals receive this drug combination prophylactically for a longer period [22].”
From Pharmacometabolomics Study of Sulfamethoxazole and Trimethoprim in Kidney Transplant Recipients: Real-World Metabolism and Urinary Excretion (2025) · cites this paper as [22]
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No references could be resolved yet.
Research works printed but not linked: 15
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Cited by
Sorted by citations
Hof, M. A. J., de Haan, H., Stepanovic, S., Bakker, S. J. L., Hak, E., Hopfgartner, G., Klont, F., & Investigators, T. (2025) · Metabolites · doi:10.3390/metabo15070473 · Cited by 1
“In the case of cotrimoxazole, immunosuppressed humans represent an interesting study domain as these individuals receive this drug combination prophylactically for a longer period [22].”
Metadata
- Authors
- Elinder, C.-G., Andersson, J., Bolinder, G., & Tydén, G.
- Affiliations
- Karolinska University Hospital (SE)
- Danderyds sjukhus (SE)
- Karolinska Institutet (SE)
- Corresponding author
- Elinder, Carl-Gustaf
- Venue
- Transplant International
- Publisher
- Frontiers Media SA
- Published
- 1992-03
- Volume
- 5
- Issue
- 2
- Pages
- 81-84
- ISSN
- 0934-0874 (ISSN-L)
- 1432-2277
- OpenAlex
- W4251159368
- Cited by
- 24
- References
- 0
- Citations by year
- 2025: 1 · 2022: 2 · 2019: 1 · 2018: 1 · 2015: 1 · 2014: 5 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transplant International (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumocystis jirovecii pneumonia detection and treatment
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- trimethoprim-sulfamethoxazole, Pneumocystis carinii pneumonia, prophylaxis, kidney transplantation, pancreas transplantation, simultaneous pancreas-kidney transplantation, opportunistic infection prophylaxis, transplant recipients, mortality
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