CYTOCHROME P450 KNOCKOUT MICE: NEW TOXICOLOGICAL MODELS
Abstract
1. Despite the frenetic pace of cytochrome P450 (CYP) research, important questions remain about the possible role of xenobiotic-metabolizing CYP in development and cellular homeostasis. 2. The recent experimental development of CYP null mouse lines has provided valuable new models for addressing these issues, as well as providing novel in vivo models to study the precise role of CYP in chemical-mediated toxicity. 3. The present review summarizes results from the three Cyp gene knockout mouse lines generated so far and looks at likely future directions of this research field. 4. Also discussed are null mouse lines with targeted mutations in genes encoding receptors having primary roles in Cyp gene regulation.
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Many physiological consequences of Ahr deletion are absent in many Cyp1 knockout animals.
“This idea is supported by the emerging observation that many physiological consequences of Ahr deletion are absent in many Cyp1 knockout animals (McKinnon & Nebert, 1998; Nukaya et al., 2009).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as McKinnon & Nebert, 1998
Cites
Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice
Bonyadi, M., Rusholme, S. A. B., Cousins, F. M., Su, H. C., Biron, C. A., Farrall, M., & Akhurst, R. J. (1997) · Nature Genetics · doi:10.1038/ng0297-207 · Cited by 166 · see citing works
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Rodent Genetic Models of Ah Receptor Signaling
Wilson, R. H., & Bradfield, C. A. (2021) · Drug Metabolism Reviews · doi:10.1080/03602532.2021.1955916 · Cited by 16 · see citing works
“This idea is supported by the emerging observation that many physiological consequences of Ahr deletion are absent in Cyp1 knockout animals (McKinnon and Nebert 1998; Nukaya et al. 2009).”
Background
- Authors
- McKinnon, R. A., & Nebert, D. W.
- Affiliations
- University of South Australia (AU)
- University of Cincinnati Medical Center (US)
- Corresponding author
- McKinnon, Ross A.
- ORCID
- McKinnon, Ross A.
- Venue
- Clinical and Experimental Pharmacology and Physiology
- Publisher
- Wiley
- Published
- 1998-10
- Volume
- 25
- Issue
- 10
- Pages
- 783-787
- ISSN
- 0305-1870 (ISSN-L)
- 1440-1681
- OpenAlex
- W2091923945
- Cited by
- 22
- References
- 1
- Citations by year
- 2024: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical and Experimental Pharmacology and Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- cytochrome P450, knockout mice, xenobiotic metabolism, receptor mutations, development (biology), cellular homeostasis
- MeSH terms
- Animals, Cytochrome P-450 Enzyme System, Mutation, Xenobiotics, Mice, Knockout, Gene Targeting, Toxicity Tests, Mice
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