Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice
Abstract
The transforming growth factor beta 1 (TGF beta 1) signalling pathway is important in embryogenesis and has been implicated in hereditary haemorrhagic telangiectasia (HHT), atherosclerosis, tumorigenesis and immunomodulation. Therefore, identification of factors which modulate TGF beta 1 bioactivity in vivo is important. On a mixed genetic background, approximately 50% Tgfb1-/- conceptuses die midgestation from defective yolk sac vasculogenesis. The other half are developmentally normal but die three weeks postpartum. Intriguingly, the vascular defects of Tgfb1-/- mice share histological similarities to lesions seen in HHT patients. It has been suggested that dichotomy in Tgfb1-/- lethal phenotypes is due to maternal TGF beta 1 rescue of some, but not all, Tgfb1-/- embryos12. Here we show that the Tgfb1-/- phenotype depends on the genetic background of the conceptus. In NIH/Ola, C57BL/6J/Ola and F1 conceptuses, Tgfb1-/- lethality can be categorized into three developmental classes. A major codominant modifier gene of embryo lethality was mapped to proximal mouse chromosome 5, using a genome scan for non-mendelian distribution of alleles in Tgfb1-/- neonatal animals which survive prenatal lethality. This gene accounts for around three quarters of the genetic effect between mouse strains and can, in part, explain the distribution of the three lethal phenotypes. This approach, using neonatal DNA samples, is generally applicable to identification of loci that influence the effect of early embryonic lethal mutations, thus furthering knowledge of genetic interactions that occur during early mammalian development in vivo.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Preclinical studies highlight extensive influences of germline genetic modifiers of TGF-β activity on tumorigenesis, vascular integrity, and allergy.
“preclinical studies highlight extensive influences of germline genetic modifiers of TGF-β activity on tumorigenesis, vascular integrity and allergy392,398–400.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [399]
Cites
Lander, E. S., Green, P., Abrahamson, J., Barlow, A., Daly, M. J., Lincoln, S. E., & Newberg, L. A. (1987) · Genomics · doi:10.1016/0888-7543(87)90010-3 · Cited by 6,657 · see citing works
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
Lander, E. S., & Kruglyak, L. (1995) · Nature Genetics · doi:10.1038/ng1195-241 · Cited by 5,196 · see citing works
Genetic Dissection of Complex Traits
Lander, E. S., & Schork, N. J. (1994) · Science · doi:10.1126/science.8091226 · Cited by 3,425 · see citing works
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985 · see citing works
Liu, J.-P., Baker, J. C., Perkins, A. S., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80084-4 · Cited by 2,854 · see citing works
Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability
Markowitz, S. D., Wang, J., Myeroff, L. L., Parsons, R. E., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., et al. (1995) · Science · doi:10.1126/science.7761852 · Cited by 2,267 · see citing works
Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967 · see citing works
McAllister, K. A., Grogg, K. M., Johnson, D. W., Gallione, C. J., Baldwin, M. A., Jackson, C. E., Helmbold, E. A., Markel, D. S., McKinnon, W. C., Murrel, J., et al. (1994) · Nature Genetics · doi:10.1038/ng1294-345 · Cited by 1,475 · see citing works
Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype
Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U. F., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., et al. (1995) · Science · doi:10.1126/science.7618084 · Cited by 1,460 · see citing works
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
George, E. L., Georges‐Labouesse, E., Patel, R., Rayburn, H., & Hynes, R. O. (1993) · Development · doi:10.1242/dev.119.4.1079 · Cited by 1,305 · see citing works
Johnson, D. W., Berg, J. N., Baldwin, M. A., Gallione, C. J., Marondel, I., Yoon, S.-H., Stenzel, T. T., Speer, M. C., Pericak‐Vance, M. A., Diamond, A. G., et al. (1996) · Nature Genetics · doi:10.1038/ng0696-189 · Cited by 1,113 · see citing works
Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice
Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., & Akhurst, R. J. (1995) · Development · doi:10.1242/dev.121.6.1845 · Cited by 1,029 · see citing works
Self-citationTransforming growth factor–β3 is required for secondary palate fusion
Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J., & Doetschman, T. (1995) · Nature Genetics · doi:10.1038/ng1295-409 · Cited by 908 · see citing works
Kimelman, D., & Kirschner, M. W. (1987) · Cell · doi:10.1016/0092-8674(87)90110-3 · Cited by 872 · see citing works
TGFβ Signaling: Receptors, Transducers, and Mad Proteins
Massagué, J. (1996) · Cell · doi:10.1016/s0092-8674(00)81296-9 · Cited by 836 · see citing works
Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., & Akhurst, R. J. (1996) · Cell · doi:10.1016/s0092-8674(00)80127-0 · Cited by 628 · see citing works
Self-citationGreen, J. B. A., & Smith, J. C. (1990) · Nature · doi:10.1038/347391a0 · Cited by 500 · see citing works
Maternal Rescue of Transforming Growth Factor-β 1 Null Mice
Letterio, J. J., Geiser, A. G., Kulkarni, A. B., Roche, N. S., Sporn, M. B., & Roberts, A. B. (1994) · Science · doi:10.1126/science.8009224 · Cited by 495 · see citing works
Rozmahe, R., Wilschanski, M. A., Matin, A., Plyte, S., Oliver, M. G., Auerbach, W., Moore, A. M., Forstner, J., Durie, P. R., Nadeau, J. H., et al. (1996) · Nature Genetics · doi:10.1038/ng0396-280 · Cited by 385 · see citing works
Grainger, D. J., Kemp, P. R., Metcalfe, J. C., Liu, A. C., Lawn, R. M., Williams, N. R., Grace, A. A., Schofield, P. M., & Chauhan, A. (1995) · Nature Medicine · doi:10.1038/nm0195-74 · Cited by 377 · see citing works
Activation of transforming growth factor-β is inhibited in transgenic apolipoprotein(a) mice
Grainger, D. J., Kemp, P. R., Liu, A. C., Lawn, R. M., & Metcalfe, J. C. (1994) · Nature · doi:10.1038/370460a0 · Cited by 352 · see citing works
Dickinson, M. E., Kobrin, M. S., Silan, C. M., Kingsley, D. M., Justice, M. J., Miller, D. A., Ceci, J. D., Lock, L. F., Lee, A. L., Buchberg, A. M., et al. (1990) · Genomics · doi:10.1016/0888-7543(90)90480-i · Cited by 140 · see citing works
Neumann, P. E., Frankel, W. N., Letts, V. A., Coffin, J. M., Copp, A. J., & Bernfield, M. R. (1994) · Nature Genetics · doi:10.1038/ng0494-357 · Cited by 119 · see citing works
RISCH, N. J., Ghosh, S., & Todd, J. A. (1993) · PubMed · Cited by 115 · see citing works
Growth factors and cytokines in health and disease
Sporn, M. B. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00004-x · Cited by 72 · see citing works
Laureys, G., Barton, D. E., Ullrich, A., & Francke, U. (1988) · Genomics · doi:10.1016/0888-7543(88)90083-3 · Cited by 72 · see citing works
The murine Il-6 gene maps to the proximal region of chromosome 5.
Mock, B. A., Nordan, R. P., Justice, M. J., Kozak, C. A., Jenkins, N. A., Copeland, N. G., Clark, S., Wong, G. G., & Rudikoff, S. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.4.1372 · Cited by 65 · see citing works
Barbarossa, S. (2002) · IEEE Signal Processing Workshop on Higher-Order Statistics · doi:10.1109/host.1993.264574 · Cited by 30 · see citing works
Avraham, K. B., Givol, D., Avivi, A., Yayon, A., Copeland, N. G., & Jenkins, N. A. (1994) · Genomics · doi:10.1006/geno.1994.1330 · Cited by 24 · see citing works
DNA Repair Defect Tied to Mutated TGF-β Receptor Gene
Marx, J. L. (1995) · Science · doi:10.1126/science.7761848 · Cited by 18 · see citing works
FGF and TGF-beta: actions and interactions in biological systems.
Kb, S., & D'Amore, P. A. (1991) · PubMed · Cited by 10 · see citing works
Gautam, S. C., Noth, C. J., Niewenhuis, L. M., Janakiraman, N., Kim, J. S., & Chopp, M. (1993) · PubMed · Cited by 9 · see citing works
The TGFβ Type II Receptor,Tgfbr2,Maps to Distal Mouse Chromosome 9
Bonyadi, M. J., Cui, W., Nagase, H., & Akhurst, R. J. (1996) · Genomics · doi:10.1006/geno.1996.0204 · Cited by 7 · see citing works
Self-citationThe murine endoglin gene (Eng) maps to chromosome 2
Qureshi, S. T., Gros, P., Letarte, M., & Malo, D. (1995) · Genomics · doi:10.1016/0888-7543(95)80099-8 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Targeting the TGFβ signalling pathway in disease
Akhurst, R. J., & Hata, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3810 · Cited by 1,466 · see citing works
Self-citationTGFβ biology in cancer progression and immunotherapy
Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944 · see citing works
Self-citationTransforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity
Pepper, M. S. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(96)00048-2 · Cited by 724 · see citing works
Kyriakides, T. R., Zhu, Y.-H., Smith, L. T., Bain, S. D., Yang, Z., Lin, M. T., Danielson, K. G., Iozzo, R. V., LaMarca, M. E., McKinney, C. E., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.2.419 · Cited by 503 · see citing works
Arthur, H. M., Ure, J. M., Smith, A. J. H., Renforth, G. L., Wilson, D. I., Torsney, E., Charlton, R., Parums, D. V., Jowett, T., Marchuk, D. A., et al. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9534 · Cited by 436 · see citing works
Raballo, R., Rhee, J., Lyn-Cook, R., Leckman, J., Schwartz, M. L., & Vaccarino, F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-13-05012.2000 · Cited by 434 · see citing works
Fedde, K. N., Blair, L. A., Silverstein, J. M., Coburn, S. P., Ryan, L. M., Weinstein, R. S., Waymire, K. G., Narisawa, S., Millán, J. L., MacGregor, G. R., et al. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.12.2015 · Cited by 405 · see citing works
Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice
Goumans, M., & Mummery, C. L. (2000) · The International Journal of Developmental Biology · doi:10.1387/ijdb.10853822 · Cited by 376 · see citing works
Loss of TGF-β1 Leads to Increased Neuronal Cell Death and Microgliosis in Mouse Brain
Brionne, T. C., Tesseur, I., Masliah, E., & Wyss-Coray, T. (2003) · Neuron · doi:10.1016/s0896-6273(03)00766-9 · Cited by 325 · see citing works
TGF-β Signaling in Control of Cardiovascular Function
Goumans, M.-J., & ten Dijke, P. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022210 · Cited by 360 · see citing works
Basement membrane and blood–brain barrier
Xu, L., Nirwane, A. M., & Yao, Y. (2018) · Stroke and Vascular Neurology · doi:10.1136/svn-2018-000198 · Cited by 356 · see citing works
Transforming growth factor‐β and Smad signalling in kidney diseases
WANG, W., Koka, V., & Lan, H. Y. (2005) · Nephrology · doi:10.1111/j.1440-1797.2005.00334.x · Cited by 347 · see citing works
A reference human induced pluripotent stem cell line for large-scale collaborative studies
Pantazis, C. B., Yang, A., Lara, E., McDonough, J. A., Blauwendraat, C., Peng, L., Oguro, H., Kanaujiya, J., Zou, J., Sebesta, D., et al. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.11.004 · Cited by 310 · see citing works
Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis
Müller, U. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00021-0 · Cited by 266 · see citing works
Relative roles of TGF‐β1 and Wnt in the systemic regulation and aging of satellite cell responses
Carlson, M. E., Conboy, M. J., Hsu, M., Barchas, L., Jeong, J., Agrawal, A., Mikels, A. J., Agrawal, S., Schaffer, D. V., & Conboy, I. M. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00517.x · Cited by 244 · see citing works
Targeting TGF-β Signaling for Therapeutic GainPreprint
Akhurst, R. J. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022301 · Cited by 243 · see citing works
Self-citationProminent role of TGF-β1 in thrombopoietin-induced myelofibrosis in mice
Chagraoui, H., Komura, E., Tulliez, M., Giraudier, S., Vainchenker, W., & Wendling, F. (2002) · Blood · doi:10.1182/blood-2002-04-1133 · Cited by 238 · see citing works
Influence of Genetic Background on Genetically Engineered Mouse Phenotypes
Doetschman, T. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-471-1_23 · Cited by 224 · see citing works
Taipale, J., Saharinen, J., & Keski‐Oja, J. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60740-x · Cited by 209 · see citing works
The embryonic origins of erythropoiesis in mammals
Baron, M. H., Isern, J., & Fraser, S. T. (2012) · Blood · doi:10.1182/blood-2012-01-153486 · Cited by 185 · see citing works
Casademunt, E., Carter, B. D., Benzel, I. M., Frade, J. M., Dechant, G., & Barde, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.6050 · Cited by 189 · see citing works
Basics of TGF-ß and Pancreatic Cancer
Truty, M. J., & Urrutia, R. A. (2007) · Pancreatology · doi:10.1159/000108959 · Cited by 185 · see citing works
Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene
LeCouter, J. E., Kablar, B., Whyte, P., Ying, C., & Rudnicki, M. A. (1998) · Development · doi:10.1242/dev.125.23.4669 · Cited by 181 · see citing works
Gomez, D. A., Zen, A. A. H., Borges, L. D. F., Philippe, M., Gutierrez, P. S., Jondeau, G., Michel, J., & Vranckx, R. (2009) · The Journal of Pathology · doi:10.1002/path.2516 · Cited by 178 · see citing works
Functions of mammalian Smad genes as revealed by targeted gene disruption in mice
Weinstein, M., Yang, X. Y., & Deng, C. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(99)00028-3 · Cited by 173 · see citing works
Chimeric Mice with Humanized Liver: Tools for the Study of Drug Metabolism, Excretion, and Toxicity
Strom, S. C., Davila, J., & Grompe, M. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-688-7_27 · Cited by 161 · see citing works
Osteopontin regulates dentin and alveolar bone development and mineralization
Foster, B. L., Ao, M., Salmon, C. R., Chavez, M. B., Kolli, T. N., Tran, A. B., Chu, E. Y., Kantovitz, K. R., Yadav, M. C., Narisawa, S., et al. (2017) · Bone · doi:10.1016/j.bone.2017.12.004 · Cited by 154 · see citing works
ahr null alleles: distinctive or different?
Lahvis, G. P., & Bradfield, C. A. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00134-8 · Cited by 152 · see citing works
Weinstein, M. B., Monga, S. P., Liu, Y., Brodie, S. G., Tang, Y., Li, C., Mishra, L., & Deng, C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5122-5131.2001 · Cited by 141 · see citing works
The role of pericytic laminin in blood brain barrier integrity maintenance
Gautam, J., Zhang, X., & Yao, Y. (2016) · Scientific Reports · doi:10.1038/srep36450 · Cited by 139 · see citing works
LeCouter, J. E., Kablar, B., Hardy, W. R., Ying, C., Megeney, L. A., May, L. L., & Rudnicki, M. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7455 · Cited by 141 · see citing works
Essential function of HIPK2 in TGFβ-dependent survival of midbrain dopamine neurons
Zhang, J., Pho, V., Bonasera, S. J., Holtzman, J., Tang, A. T., Hellmuth, J. M., Tang, S., Janak, P. H., Tecott, L. H., & Huang, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1816 · Cited by 134 · see citing works
Transforming growth factor β (TGF-β) and autoimmunity
Aoki, C. A., Borchers, A. T., Li, M. O., Flavell, R. A., Bowlus, C. L., Ansari, A. A., & Gershwin, M. E. (2005) · Autoimmunity Reviews · doi:10.1016/j.autrev.2005.03.006 · Cited by 123 · see citing works
Tranguch, S., Wang, H., Daikoku, T., Xie, H., Smith, D. F., & Dey, S. K. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31622 · Cited by 121 · see citing works
Yoon, J.-H., Sudo, K., Kuroda, M., Kato, M., Lee, I., Han, J. S., Nakae, S., Imamura, T., Kim, J., Ju, J. H., et al. (2015) · Nature Communications · doi:10.1038/ncomms8600 · Cited by 120 · see citing works
Molecular Basis of Vascular Anomalies
Vikkula, M. (1998) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(98)00024-3 · Cited by 120 · see citing works
Wang, H., Ma, W.-G., Tejada, L. V., Zhang, H., Morrow, J. D., Das, S. K., & Dey, S. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312203200 · Cited by 119 · see citing works
McCartney-Francis, N. L., Frazier-Jessen, M. R., & Wahl, S. M. (1998) · International Reviews of Immunology · doi:10.3109/08830189809043009 · Cited by 117 · see citing works
Takeuchi, T., Kojima, M., Nakajima, K., & Kondo, S. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00100-8 · Cited by 111 · see citing works
Rı́us, C., Smith, J. D., Almendro, N., Langa, C., Botella, L. M., Marchuk, D. A., Vary, C., & Bernabéu, C. (1998) · Blood · doi:10.1182/blood.v92.12.4677 · Cited by 111 · see citing works
Bourdeau, A., Faughnan, M. E., McDonald, M., Paterson, A. D., Wanless, I. R., & Letarte, M. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64673-1 · Cited by 110 · see citing works
Goumans, M., Zwijsen, A., van Rooijen, M. A., Huylebroeck, D., Roelen, B. A. J., & Mummery, C. L. (1999) · Development · doi:10.1242/dev.126.16.3473 · Cited by 110 · see citing works
Rennebeck, G., Kleymenova, E., Anderson, R., Yeung, R. S. W., Artzt, K., & Walker, C. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15629 · Cited by 107 · see citing works
Transforming growth factor beta signaling in adult cardiovascular diseases and repair
Doetschman, T., Barnett, J. V., Runyan, R. B., Camenisch, T. D., Heimark, R. L., Granzier, H. L. M., Conway, S. J., & Azhar, M. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1241-3 · Cited by 103 · see citing works
Gomez, D. A., Coyet, A., Ollivier, V., Jeunemaı̂tre, X., Jondeau, G., Michel, J., & Vranckx, R. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq291 · Cited by 99 · see citing works
Papetti, M., Shujath, J., Riley, K. N., & Herman, I. M. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0291 · Cited by 97 · see citing works
Lipid signaling in embryo implantation
Wang, H., & Dey, S. K. (2004) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2004.09.013 · Cited by 94 · see citing works
G enetically A ltered M ouse M odels: the G ood, the B ad, and the U gly
Thyagarajan, T., Totey, S. M., Danton, M. J. S., & Kulkarni, A. B. (2003) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130301400302 · Cited by 92 · see citing works
Gorham, J. D., Lin, J. T., Sung, J. L., Rudner, L. A., & French, M. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.10.6413 · Cited by 89 · see citing works
Mutations of TGFß signaling molecules in human disease
Harradine, K. A., & Akhurst, R. J. (2006) · Annals of Medicine · doi:10.1080/07853890600919911 · Cited by 87 · see citing works
Self-citationModelling neuroinflammatory phenotypes in vivo.
Buckwalter, M. S., & Wyss‐Coray, T. (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-10 · Cited by 85 · see citing works
Coppen, S. R., Severs, N. J., & Gourdie, R. G. (1999) · Developmental Genetics · doi:10.1002/(sici)1520-6408(1999)24:1/2 · Cited by 191 · see citing works
DNA-protein interactions in the CCAAT box region of the murine lactate dehydrogenase C promoter
Ambhaikar, M., & Goldberg, E. (1999) · Molecular Reproduction and Development · doi:10.1002/(sici)1098-2795(199904)52:4 · Cited by 4 · see citing works
Yao, Y. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18801467 · Cited by 82 · see citing works
Gralinski, L. E., Menachery, V. D., Morgan, A. P., Totura, A. L., Beall, A. E., Kocher, J., Plante, J. A., Harrison-Shostak, D. C., Schäfer, A., de Villena, F. P., et al. (2017) · G3 Genes Genomes Genetics · doi:10.1534/g3.117.041434 · Cited by 75 · see citing works
Ingman, W. V., Robker, R. L., Woittiez, K. J., & Robertson, S. A. (2005) · Endocrinology · doi:10.1210/en.2005-1189 · Cited by 75 · see citing works
Transforming Growth Factor-β in Renal Disease
Bitzer, M., Sterzel, R. B., & Böttinger, E. P. (1998) · Kidney & Blood Pressure Research · doi:10.1159/000025837 · Cited by 75 · see citing works
Sprunger, L. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.3.471 · Cited by 72 · see citing works
Benzinou, M., Clermont, F. F., Letteboer, T. G. W., Kim, J.-H., Espejel, S., Harradine, K. A., Arbelaez, J., Luu, M. T., Roy, R., Quigley, D. A., et al. (2012) · Nature Communications · doi:10.1038/ncomms1633 · Cited by 67 · see citing works
Self-citationBeta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse.
Kobayashi, S., Yoshida, K., Ward, J. M., Letterio, J. J., Longenecker, G., Yaswen, L. R., Mittleman, B. B., Mozes, E., Roberts, A. B., Karlsson, S., et al. (1999) · PubMed · Cited by 65 · see citing works
TGFβ1 and TGFβ3 are partially redundant effectors in brain vascular morphogenesis
Mu, Z., Yang, Z., Yu, D., Zhao, Z., & Munger, J. S. (2008) · Mechanisms of Development · doi:10.1016/j.mod.2008.01.003 · Cited by 64 · see citing works
Pericytic Laminin Maintains Blood-Brain Barrier Integrity in an Age-Dependent Manner
Gautam, J., Cao, Y., & Yao, Y. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00709-8 · Cited by 60 · see citing works
Kim, J.-H., Peacock, M. R., George, S. C., & Hughes, C. C. W. (2012) · Angiogenesis · doi:10.1007/s10456-012-9277-x · Cited by 60 · see citing works
β2-Microglobulin-Deficient Background Ameliorates Lethal Phenotype of the TGF-β1 Null Mouse
Kobayashi, S., Yoshida, K., Ward, J. M., Letterio, J. J., Longenecker, G., Yaswen, L. R., Mittleman, B. B., Mozes, E., Roberts, A. B., Karlsson, S., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.4013 · Cited by 58 · see citing works
Progesterone receptor requires a co-chaperone for signalling in uterine biology and implantation
Tranguch, S. L., Smith, D. F., & Dey, S. K. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60655-4 · Cited by 53 · see citing works
“Gene‐Swap Knock‐in” Cassette in Mice to Study Allelic Differences in Human Genes
Nebert, D. W., Dalton, T. P., Stuart, G. W., & Carvan, M. J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06876.x · Cited by 53 · see citing works
Factors in the Genetic Background Suppress theEngrailed-1Cerebellar Phenotype
Bilovocky, N. A., Romito‐DiGiacomo, R. R., Murcia, C. L., Maricich, S. M., & Herrup, K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05105.2003 · Cited by 53 · see citing works
Frutkin, A. D., Shi, H., Otsuka, G., Levéen, P., Karlsson, S., & Dichek, D. A. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.06.067 · Cited by 52 · see citing works
Ingman, W. V., & Robertson, S. A. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.107.067272 · Cited by 52 · see citing works
Lemos, M. C., Harding, B., Reed, A. J., Jeyabalan, J., Walls, G. V., Bowl, M. R., Sharpe, J. A., Wedden, S. E., Moss, J. E., Ross, A., et al. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0124 · Cited by 51 · see citing works
TGF-β Knockout and Dominant-Negative Receptor Transgenic Mice
Letterio, J. J., & Böttinger, E. P. (1998) · Mineral and Electrolyte Metabolism · doi:10.1159/000057365 · Cited by 51 · see citing works
Influence of Genetic Background on Knockout Mouse Phenotypes
Sanford, L. P., Kallapur, S. G., Ormsby, I., & Doetschman, T. (2003) · Humana Press eBooks · doi:10.1385/1-59259-220-1:217 · Cited by 49 · see citing works
Pratiwi, R., Fletcher, L. M., Pyper, W. R., Do, K.-A., Crawford, D. H., Powell, L. W., & Jazwinska, E. C. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80161-5 · Cited by 49 · see citing works
Accili, D., Nakae, J., Kim, J. J., Park, B. C., & Rother, K. I. (1999) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.1999.12.4.475 · Cited by 49 · see citing works
Chandler, C. H., Chari, S., Kowalski, A., Choi, L., Tack, D. C., DeNieu, M., Pitchers, W., Sonnenschein, A., Marvin, L., Hummel, K., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1007075 · Cited by 48 · see citing works
Kawasaki, K., Freimuth, J., Meyer, D. S., Lee, M. M., Tochimoto-Okamoto, A., Benzinou, M., Clermont, F. F., Wu, G., Roy, R., Letteboer, T. G. W., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318761111 · Cited by 47 · see citing works
Self-citationPhysiological consequences of β-adrenergic receptor disruption
Rohrer, D. K. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050278 · Cited by 44 · see citing works
Embryonic Fibroblasts from Mice Lacking Tgif Were Defective in Cell Cycling
Mar, L., & Hoodless, P. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02156-05 · Cited by 39 · see citing works
Genetic modifiers interact with maternal determinants in vascular development of Tgfb1(-/-) mice.
Tang, Y., McKinnon, M., Leong, L., Rusholme, S., Wang, S., & Akhurst, R. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg164 · Cited by 39 · see citing works
Wiede, F., Chew, S., van Vliet, C., Poulton, I. J., Kyparissoudis, K., Sasmono, R. T., Loh, K., Tremblay, M. L., Godfrey, D. I., Sims, N. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036703 · Cited by 38 · see citing works
Role of TGF-? in immune-evasion of cancer
Beck, C., Schreiber, H. W., & Rowley, D. A. (2001) · Microscopy Research and Technique · doi:10.1002/1097-0029(20010215)52:4 · Cited by 103 · see citing works
A major role of TGF-β1 in the homing capacities of murine hematopoietic stem cell/progenitors
Capron, C., Lacout, C., Lécluse, Y., Jalbert, V., Chagraoui, H., Charrier, S., Galy, A. H. M., Griscelli, A. B., Cramer, E. M., & Vainchenker, W. (2010) · Blood · doi:10.1182/blood-2009-05-221093 · Cited by 37 · see citing works
Inflammation and TGFβ1: Lessons from the TGFβ1 null mouse
Kulkarni, A. B., & Karlsson, S. (1997) · Research in Immunology · doi:10.1016/s0923-2494(97)82669-7 · Cited by 37 · see citing works
Rosendahl, A. (2003) · International Immunology · doi:10.1093/intimm/dxg139 · Cited by 34 · see citing works
SMAD6-deficiency in human genetic disorders
Luyckx, I., Verstraeten, A., Goumans, M., & Loeys, B. (2022) · npj Genomic Medicine · doi:10.1038/s41525-022-00338-5 · Cited by 34 · see citing works
The Roles of Smad2 and Smad3 in the Development of Chemically Induced Skin Tumors in Mice
Tannehill‐Gregg, S. H., Kusewitt, D. F., Rosol, T. J., & Weinstein, M. B. (2004) · Veterinary Pathology · doi:10.1354/vp.41-3-278 · Cited by 31 · see citing works
Goumans, M., Oostwaard, D. W., Wianny, F., Savatier, P., Zwijsen, A., & Mummery, C. L. (1998) · Differentiation · doi:10.1046/j.1432-0436.1998.6330101.x · Cited by 30 · see citing works
Hhex and Cer1 Mediate the Sox17 Pathway for Cardiac Mesoderm Formation in Embryonic Stem Cells
Liu, Y., Kaneda, R., Leja, T., Subkhankulova, T., Tolmachov, O. E., Minchiotti, G., Schwartz, R. J., Barahona, M., & Schneider, M. D. (2014) · Stem Cells · doi:10.1002/stem.1695 · Cited by 29 · see citing works
Uno, S., Endo, K., Ishida, Y., Tateno, C., Makishima, M., Yoshizato, K., & Nebert, D. W. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.03.001 · Cited by 29 · see citing works
Ohno, Y., Tanase, H., Nabika, T., Otsuka, K., Sasaki, T., Suzawa, T., Morii, T., Yamori, Y., & Saruta, T. (2000) · Genetics · doi:10.1093/genetics/155.2.785 · Cited by 28 · see citing works
Transforming growth factor beta 1 may regulate the stability of mature myelin sheaths
Day, W. A., Koishi, K., & McLennan, I. S. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00308-x · Cited by 27 · see citing works
Tang, Y., Lee, K. S., Yang, H., Logan, D. W., Wang, S., McKinnon, M. L., Holt, L. J., Condie, A., Luu, M. T., & Akhurst, R. J. (2004) · Genomics · doi:10.1016/j.ygeno.2004.09.003 · Cited by 27 · see citing works
Self-citationRole of TGF-β in Vascular Development and Vascular Reactivity
Perrella, M. A., Jain, M. K., & Lee, M.-E. (1998) · Mineral and Electrolyte Metabolism · doi:10.1159/000057361 · Cited by 27 · see citing works
Kobayashi, R., Terakawa, J., Kato, Y., Azimi, S., Inoue, N., Ohmori, Y., & Hondo, E. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.03.011 · Cited by 26 · see citing works
Neurotrophins enhance electric field-directed growth cone guidance and directed nerve branching
McCaig, C., Sangster, L., & Stewart, R. (2000) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(200003)217:3 · Cited by 100 · see citing works
Wu, B. X., Li, A., Lei, L., Kaneko, S., Wallace, C. H., Li, X., & Li, Z. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.797613 · Cited by 24 · see citing works
CYTOCHROME P450 KNOCKOUT MICE: NEW TOXICOLOGICAL MODELS
McKinnon, R. A., & Nebert, D. W. (1998) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1998.tb02153.x · Cited by 22 · see citing works
What do polymorphisms tell us about the mechanisms of COPD?
Li, Y., Cho, M. H., & Zhou, X. (2017) · Clinical Science · doi:10.1042/cs20160718 · Cited by 20 · see citing works
Probing Human Cardiovascular Congenital Disease Using Transgenic Mouse Models
Snider, P. L., & Conway, S. J. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-384878-9.00003-0 · Cited by 21 · see citing works
Zwijsen, A., Goumans, M., Lawson, K. A., van Rooijen, M. A., & Mummery, C. L. (1999) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199902)214:2 · Cited by 21 · see citing works
- Authors
- Bonyadi, M., Rusholme, S. A. B., Cousins, F. M., Su, H. C., Biron, C. A., Farrall, M., & Akhurst, R. J.
- Affiliations
- University of Glasgow (GB)
- University of Oxford (GB)
- Brown University (US)
- Centre for Human Genetics (GB)
- Corresponding author
- Akhurst, Rosemary J.
- Venue
- Nature Genetics
- Published
- 1997-02
- Volume
- 15
- Issue
- 2
- Pages
- 207-211
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2064113953
- Cited by
- 166
- References
- 34
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 7 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 7
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- TGF-β1, embryonic lethality, genetic modifiers, hereditary hemorrhagic telangiectasia, chromosome 5, genetic background, genome scan, mouse strains
- MeSH terms
- Animals, Chromosome Mapping, Crosses, Genetic, Fetal Death, Embryonic and Fetal Development, Genes, Lethal, Hematopoiesis, Mice, Inbred C57BL, Phenotype, Yolk Sac, Transforming Growth Factor beta, Mice, Knockout, Microsatellite Repeats, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review