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Cited by 6Blood Pressure and Hypertension StudiesHormonal Regulation and HypertensionAnimal testing and alternatives

Species variability in cardiovascular research: the example of adrenocorticotrophin-induced hypertension

Whitworth, Judith A, Zhang, Yi, Mangos, George, Kelly, John J·2006·Clinical and Experimental Pharmacology and Physiology
DOI 10.1111/j.1440-1681.2006.04460.x
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Abstract

1. Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies. 2. Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans. 3. A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4. Caution should be exercised in extrapolating data from animals to humans.

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Crossref · 10.1111/j.1440-1681.2006.04460.x

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51 of 51 references verified0 citation errors · 0 not checkable

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  • ACTH-induced hypertension depends on intact adrenal gland function since adrenal insufficiency or adrenalectomy prevents increased blood pressure in subjects with high levels of ACTH.

    “ACTH-induced hypertension depends on intact adrenal gland function since adrenal insufficiency or adrenalectomy prevents increased BP in subjects with high levels of ACTH [13].”

    From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [13]

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Authors
Whitworth, J. A., Zhang, Y., Mangos, G., & Kelly, J. J.
Affiliations
  • Australian National University (AU)
  • St George Hospital (AU)
Corresponding author
Whitworth, Judith A
ORCID
Venue
Clinical and Experimental Pharmacology and Physiology
Publisher
Wiley
Published
2006-08-10
Volume
33
Issue
9
Pages
887-891
ISSN
  • 0305-1870 (ISSN-L)
  • 1440-1681
DOI
10.1111/j.1440-1681.2006.04460.x
OpenAlex
W2167224973
Cited by
6
References
51
Citations by year
2017: 1 · 2013: 1
FWCI
0.11
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical and Experimental Pharmacology and Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • ANU Open Research (Australian National University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
Keywords
ACTH, ACTH-induced hypertension, species variation, animal-to-human extrapolation, cardiovascular effects, hypertension, animal models of hypertension
MeSH terms
Adrenocorticotropic Hormone, Animals, Blood Flow Velocity, Blood Pressure, Cardiovascular Physiological Phenomena, Dogs, Humans, Hypertension, Nitric Oxide, Research Design, Gonadal Steroid Hormones, Sheep, Species Specificity, Models, Animal, Mice, Rats

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