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ISCOMTM‐based vaccines: The second decade
Open accessAbstract
The immunostimulating complex or ‘iscom’ was first described 20 years ago as an antigen delivery system with powerful immunostimulating activity. Iscoms are cage‐like structures, typically 40 nm in diameter, that are comprised of antigen, cholesterol, phospholipid and saponin. ISCOM TM‐based vaccines have been shown to promote both antibody and cellular immune responses in a variety of experimental animal models. This review focuses on the evaluation of ISCOM TM‐based vaccines in animals over the past 10 years, as well as examining the progress that has been achieved in the development of human vaccines based on ISCOM TM adjuvant technology.
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Cited by
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Guy, B. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1681 · Cited by 620
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Skwarczynski, M., & Toth, I. (2016) · Chemical Science · doi:10.1039/c5sc03892h · Cited by 596
Influenza Virus: Dealing with a Drifting and Shifting Pathogen
Kim, H., Webster, R. G., & Webby, R. J. (2018) · Viral Immunology · doi:10.1089/vim.2017.0141 · Cited by 419
Novel approaches for the design, delivery and administration of vaccine technologies
Wallis, J., Shenton, D. P., & Carlisle, R. C. (2019) · Clinical and Experimental Immunology · doi:10.1111/cei.13287 · Cited by 123
Metadata
- Authors
- Sanders, M. T., Brown, L. E., Deliyannis, G., & Pearse, M. J.
- Venue
- Immunology & Cell Biology
- Publisher
- Wiley
- Published
- 2005-04
- Volume
- 83
- Issue
- 2
- Pages
- 119-128
- ISSN
- 0004-945X (ISSN-L)
- 0818-9641
- 1440-1711
- OpenAlex
- W2048175618
- Cited by
- 166
- References
- 0
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sanders, M. T., Brown, L. E., Deliyannis, G., & Pearse, M. J. (2005). ISCOMTM‐based vaccines: The second decade. Immunology & Cell Biology. https://doi.org/10.1111/j.1440-1711.2005.01319.x
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