Proposals for prevention and management of steroid-induced osteoporosis in children and adolescents
Abstract
The adverse effects of glucocorticoids on bone health are well recognized. In adults, evidence-based guidelines exist to base management of patients with glucocorticoid-induced osteoporosis. Osteoporosis is also recognized in children and adolescents with chronic disease requiring steroid treatment. Additional complexities in the assessment and management of growing children mean that evidence-based guidelines for this complex patient group have not been produced. Factors, which need to be taken into account, include defining osteoporosis in childhood and addressing the effects of chronic disease and glucocorticoid treatment on a number of parameters including the skeleton, growth, puberty, nutrition and vitamin D status. In the absence of randomized controlled trials to guide clinical practice, we provide proposals for the prevention and management of steroid-induced osteoporosis, drawing on the available evidence and our clinical experience of managing children and adolescents with steroid-induced osteoporosis.
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Continued and safety studies for the use of bisphosphonates in children have yet to be established.
“To this end, continued and safety studies for the use of BPs in children have yet to be established [18-20].”
From Prevention of glucocorticoid induced bone changes with beta-ecdysone (2015) · cites this paper as [18]
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Prevention of glucocorticoid induced bone changes with beta-ecdysone
Dai, W., Jiang, L., Lay, Y.-A. E., Chen, H., Jin, G., Zhang, H., Kot, A., Ritchie, R. O., Lane, N. E., & Yao, W. (2015) · Bone · doi:10.1016/j.bone.2015.01.001 · Cited by 30 · see citing works
- Authors
- Brown, J., & Zacharin, M.
- Affiliations
- Royal Children's Hospital (AU)
- Venue
- Journal of Paediatrics and Child Health
- Publisher
- Wiley
- Published
- 2005-11
- Volume
- 41
- Issue
- 11
- Pages
- 553-557
- ISSN
- 1034-4810 (ISSN-L)
- 1440-1754
- OpenAlex
- W2169042369
- Cited by
- 36
- References
- 61
- Citations by year
- 2025: 1 · 2020: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Paediatrics and Child Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Keywords
- glucocorticoid-induced osteoporosis, children and adolescents, bone health, glucocorticoid adverse effects, children with chronic illness, growth, puberty, nutrition, vitamin D status, osteoporosis prevention, osteoporosis management
- MeSH terms
- Adolescent, Australia, Bone Resorption, Child, Child Development, Diphosphonates, Glucocorticoids, Humans, National Health Programs, Osteoporosis, Bone Density
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